Recent advances in hapalindole-type cyanobacterial alkaloids: biosynthesis, synthesis, and biological activity

2021 ◽  
Author(s):  
Robert M. Hohlman ◽  
David H. Sherman
Keyword(s):  
Biological Activity ◽  
Total Synthesis ◽  
Indole Alkaloids ◽  
Recent Advances

This review covers isolation, biological activity, an overview of total synthesis efforts and recent biosynthetic discoveries related to hapalindole-type indole alkaloids.

Recent advances on the synthesis of the antidepressant Paroxetine

2020 ◽  
Vol 27 ◽  
Author(s):  
Joana Santos ◽  
M. Fernanda Proença ◽  
Ana Joao Rodrigues ◽  
Patricia Patrício ◽  
H. Sofia Domingues
Keyword(s):  
Total Synthesis ◽  
Neurological Disorders ◽  
Serotonin Reuptake ◽  
Potent Inhibitor ◽  
Starting Material ◽  
Substitution Pattern ◽  
Biological Probes ◽  
Recent Advances ◽  
Treatment Of Depression ◽  
Made In

: Paroxetine is a potent inhibitor of serotonin reuptake and is widely prescribed for the treatment of depression and other neurological disorders. The synthesis of paroxetine and the possibility to prepare derivatives with a specific substitution pattern that may allow their use as biological probes, is an attractive topic especially for medicinal chemists engaged in neurosciences research. Considering the extensive work that was developed in the last decade on the total synthesis of paroxetine, this review summarizes the most important contributions in this field, organized according to the reagent that was used as starting material. Most of the methods allowed to prepare paroxetine in 4-9 steps with an overall yield of 9-66%. Despite the progress made in this area, there is still room for improvement, searching for new eco-friendly and sustainable synthetic alternatives.

scholarly journals The chemistry of mavacurane alkaloids: a rich source of bis-indole alkaloids

2021 ◽  
Author(s):  
Audrey Mauger ◽  
Maxime Jarret ◽  
Cyrille Kouklovsky ◽  
Erwan Poupon ◽  
Laurent Evanno ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Indole Alkaloids ◽  
Rich Source ◽  
Monoterpene Indole Alkaloids

This review presents the chemistry of mavacuranes, a subfamily of the monoterpene indole alkaloids, from their isolation, biosynthesis, total synthesis to their tendency to assemble with other partners to form intricate bis-indole alkaloids.

Structure, biological activity, and a biomimetic partial synthesis of the lirofolines, novel pentacylic indole alkaloids from Tabernaemontana

2010 ◽  
Vol 51 (2) ◽  
pp. 269-272 ◽  
Author(s):  
Yun-Yee Low ◽  
Kuan-Hon Lim ◽  
Yeun-Mun Choo ◽  
Huey-Shen Pang ◽  
Tadahiro Etoh ◽  
...  
Keyword(s):  
Biological Activity ◽  
Indole Alkaloids ◽  
Partial Synthesis

scholarly journals Total Synthesis of (−)-Vitrenal and Its Biological Activity

1986 ◽  
Vol 59 (6) ◽  
pp. 1897-1900 ◽  
Author(s):  
Mitsuaki Kodama ◽  
Usman S. F. Tambunan ◽  
Tetsuto Tsunoda ◽  
Shô Itô
Keyword(s):  
Biological Activity ◽  
Total Synthesis

Asymmetric organocatalytic methods for the synthesis of tetrahydropyrans and their application in total synthesis

2017 ◽  
Vol 46 (6) ◽  
pp. 1661-1674 ◽  
Author(s):  
Fabrizio Vetica ◽  
Pankaj Chauhan ◽  
Simon Dochain ◽  
Dieter Enders
Keyword(s):  
Total Synthesis ◽  
Recent Advances

This review describes the recent advances on the asymmetric organocatalytic synthesis of THPs and their application in total synthesis.

The presence of food-derived collagen peptides in human body-structure and biological activity

2017 ◽  
Vol 8 (12) ◽  
pp. 4325-4330 ◽  
Author(s):  
Kenji Sato
Keyword(s):  
Biological Activity ◽  
Human Body ◽  
Biological Activities ◽  
Body Structure ◽  
Collagen Peptides ◽  
Recent Advances

While it was difficult to detect food-derived peptide in blood (A), recent advances enables identify them (B) and examine their biological activities.

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