Synthesis of Aminopropyl Phosphonate Nucleosides with Purine and Pyrimidine Bases

2006 ◽  
Vol 71 (1) ◽  
pp. 15-34 ◽  
Author(s):  
Ding Zhou ◽  
Irene M. Lagoja ◽  
Arthur Van Aerschot ◽  
Piet Herdewijn
Keyword(s):  
Nucleotide Analogues ◽  
Pyrimidine Nucleotide ◽  
Virus Activity ◽  
Pyrimidine Bases

The synthesis and antiviral evaluation of new acyclic phosphonate nucleosides related to HPMPC (Cidofovir) has been described. These aminopropyl phosphonate nucleosides 1-3 have an amino function within either the acyclic chain (series 2 and 3) or as substituent (series 1). Both purine and pyrimidine nucleotide analogues have been synthesized. In contrast to HPMPC the oxygen analogue of 2c, only a weak antiherpes virus activity could be demonstrated for 2b and 2c.

Anti-Hepatitis B Virus Activity in Vitro of Combinations of Tenofovir with Nucleoside/nucleotide Analogues

2009 ◽  
Vol 19 (4) ◽  
pp. 165-176 ◽  
Author(s):  
Yuao Zhu ◽  
Maria Curtis ◽  
Xiaoping Qi ◽  
Michael D Miller ◽  
Katyna Borroto-Esoda
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Nucleotide Analogues ◽  
Virus Activity ◽  
B Virus

scholarly journals 2-/5-Substituted uracil-1-yl/tetrahydrofuran-5-carboxylic acids as pyrimidine nucleotide analogues

1978 ◽  
Vol 5 (suppl_1) ◽  
pp. s19-s24 ◽  
Author(s):  
R.A. Zhuk ◽  
A.E. Berzin ◽  
V.N. Silin ◽  
E.E. Liepinsh
Keyword(s):  
Carboxylic Acids ◽  
Nucleotide Analogues ◽  
Pyrimidine Nucleotide

Synthesis and Biological Evaluation of Acyclic Nucleotide Analogues of Bicyclic Pyrimidine Bases

2009 ◽  
Vol 82 (2) ◽  
pp. A58-A59 ◽  
Author(s):  
Zlatko Janeba ◽  
Antonín Holý ◽  
Robert Snoeck ◽  
Graciela Andrei ◽  
Eric De Clercq ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Nucleotide Analogues ◽  
Pyrimidine Bases ◽  
Synthesis And Biological Evaluation

Compounds with anti-respiratory syncytial virus activity from endophytic fungus Pestalotiopsis thea

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
PF Uzor ◽  
DC Odimegwu ◽  
W Ebrahim ◽  
PO Osadebe ◽  
NJ Nwodo ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Endophytic Fungus ◽  
Virus Activity ◽  
Syncytial Virus

Evaluation of the anti-herpes simplex virus activity of Thymus longicaulis L. (Lamiaceae)

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
MK Matta ◽  
K Paltatzidou ◽  
H Triantafyllidou ◽  
DM Lazari ◽  
A Karioti ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Activity ◽  
Simplex Virus
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