Bismethylene Triphosphate Nucleotides of Uridine 4-Phosphate Analogues:  A New Class of Anionic Pyrimidine Nucleotide Analogues

2008 ◽  
Vol 73 (4) ◽  
pp. 1403-1412 ◽  
Author(s):  
Scott D. Taylor ◽  
Farzad Mirzaei ◽  
Stephen L. Bearne
Keyword(s):  
Nucleotide Analogues ◽  
New Class ◽  
Pyrimidine Nucleotide

ChemInform Abstract: A New Class of Acyclic Phosphonate Nucleotide Analogues: Phosphonate Isosters of Acyclovir and Ganciclovir Monophosphates as Antiviral Agents.

ChemInform ◽  
2010 ◽  
Vol 23 (2) ◽  
pp. no-no
Author(s):  
C. U. KIM ◽  
P. F. MISCO ◽  
B. Y. LUH ◽  
M. J. M. HITCHCOOK ◽  
I. GHAZZOULI ◽  
...  
Keyword(s):  
Antiviral Agents ◽  
Nucleotide Analogues ◽  
New Class

scholarly journals 2-/5-Substituted uracil-1-yl/tetrahydrofuran-5-carboxylic acids as pyrimidine nucleotide analogues

1978 ◽  
Vol 5 (suppl_1) ◽  
pp. s19-s24 ◽  
Author(s):  
R.A. Zhuk ◽  
A.E. Berzin ◽  
V.N. Silin ◽  
E.E. Liepinsh
Keyword(s):  
Carboxylic Acids ◽  
Nucleotide Analogues ◽  
Pyrimidine Nucleotide

Nucleoside H-boranophosphonates: a new class of boron-containing nucleotide analogues

2009 ◽  
pp. 2466 ◽  
Author(s):  
Renpei Higashida ◽  
Natsuhisa Oka ◽  
Toshihide Kawanaka ◽  
Takeshi Wada
Keyword(s):  
Nucleotide Analogues ◽  
New Class

ChemInform Abstract: Nucleoside H-Boranophosphonates: A New Class of Boron-Containing Nucleotide Analogues.

ChemInform ◽  
2009 ◽  
Vol 40 (37) ◽  
Author(s):  
Renpei Higashida ◽  
Natsuhisa Oka ◽  
Toshihide Kawanaka ◽  
Takeshi Wada
Keyword(s):  
Nucleotide Analogues ◽  
New Class

Synthesis of Aminopropyl Phosphonate Nucleosides with Purine and Pyrimidine Bases

2006 ◽  
Vol 71 (1) ◽  
pp. 15-34 ◽  
Author(s):  
Ding Zhou ◽  
Irene M. Lagoja ◽  
Arthur Van Aerschot ◽  
Piet Herdewijn
Keyword(s):  
Nucleotide Analogues ◽  
Pyrimidine Nucleotide ◽  
Virus Activity ◽  
Pyrimidine Bases

The synthesis and antiviral evaluation of new acyclic phosphonate nucleosides related to HPMPC (Cidofovir) has been described. These aminopropyl phosphonate nucleosides 1-3 have an amino function within either the acyclic chain (series 2 and 3) or as substituent (series 1). Both purine and pyrimidine nucleotide analogues have been synthesized. In contrast to HPMPC the oxygen analogue of 2c, only a weak antiherpes virus activity could be demonstrated for 2b and 2c.

In Situ microscopy of the anodic etching of silicon

1995 ◽  
Vol 53 ◽  
pp. 232-233
Author(s):  
Frances M. Ross ◽  
Peter C. Searson
Keyword(s):  
Composite Structures ◽  
High Surface ◽  
High Surface Area ◽  
Chemical Properties ◽  
Selective Etching ◽  
Silicon On Insulator ◽  
Second Phase ◽  
Porous Layers ◽  
New Class ◽  
Porous Semiconductors

Porous semiconductors represent a relatively new class of materials formed by the selective etching of a single or polycrystalline substrate. Although porous silicon has received considerable attention due to its novel optical properties1, porous layers can be formed in other semiconductors such as GaAs and GaP. These materials are characterised by very high surface area and by electrical, optical and chemical properties that may differ considerably from bulk. The properties depend on the pore morphology, which can be controlled by adjusting the processing conditions and the dopant concentration. A number of novel structures can be fabricated using selective etching. For example, self-supporting membranes can be made by growing pores through a wafer, films with modulated pore structure can be fabricated by varying the applied potential during growth, composite structures can be prepared by depositing a second phase into the pores and silicon-on-insulator structures can be formed by oxidising a buried porous layer. In all these applications the ability to grow nanostructures controllably is critical.

The microtubule associated protein (MAP) tau forms a new class of triple-stranded left-hand helical fibrous protein polymer

1992 ◽  
Vol 50 (1) ◽  
pp. 540-541
Author(s):  
G. C. Ruben ◽  
K. Iqbal ◽  
I. Grundke-Iqbal ◽  
H. Wisniewski ◽  
T. L. Ciardelli ◽  
...  
Keyword(s):  
Axial Ratio ◽  
Normal Structure ◽  
Paired Helical Filaments ◽  
Left Hand ◽  
New Class ◽  
Protein Polymer ◽  
Fibrous Protein ◽  
Protein Map ◽  
Neurotransmitter Transport ◽  
Alzheimer Neurofibrillary Tangles

In neurons, the microtubule associated protein, tau, is found in the axons. Tau stabilizes the microtubules required for neurotransmitter transport to the axonal terminal. Since tau has been found in both Alzheimer neurofibrillary tangles (NFT) and in paired helical filaments (PHF), the study of tau's normal structure had to preceed TEM studies of NFT and PHF. The structure of tau was first studied by ultracentrifugation. This work suggested that it was a rod shaped molecule with an axial ratio of 20:1. More recently, paraciystals of phosphorylated and nonphosphoiylated tau have been reported. Phosphorylated tau was 90-95 nm in length and 3-6 nm in diameter where as nonphosphorylated tau was 69-75 nm in length. A shorter length of 30 nm was reported for undamaged tau indicating that it is an extremely flexible molecule. Tau was also studied in relation to microtubules, and its length was found to be 56.1±14.1 nm.

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