Synthesis and Antifungal Activity of New Indolylthiazinone Derivatives

1998 ◽  
Vol 63 (1) ◽  
pp. 94-102 ◽  
Author(s):  
Milan Dzurilla ◽  
Peter Kutschy ◽  
Jalpa P. Tewari ◽  
Martin Ružinský ◽  
Stanislav Šenvický ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Intramolecular Cyclization ◽  
Boron Trifluoride ◽  
Alternaria Brassicicola ◽  
Alternaria Brassicae

New 6-(indol-3-yl)-5,6-dihydro-4H-1,3-thiazin-4-one derivatives were prepared by boron trifluoride catalyzed intramolecular cyclization of N'-substituted N-[3-(indol-3-yl)propenoyl]thioureas and by the reaction of 3-(indol-3-yl)propenoyl isothiocyanate with sodium hydrogensulfide. Antifungal activity of the prepared compounds was studied using the fungi Alternaria brassicae and Alternaria brassicicola.

Application of 2-Substituted Ethyl Isothiocyanates and 2-Aminothiols in the Synthesis of the Analogs of Indole Phytoalexin Camalexin

1999 ◽  
Vol 64 (9) ◽  
pp. 1448-1456 ◽  
Author(s):  
Milan Dzurilla ◽  
Martin Ružinský ◽  
Peter Kutschy ◽  
Jalpa P. Tewari ◽  
Vladimír Kováčik
Keyword(s):  
Antifungal Activity ◽  
Boron Trifluoride ◽  
Boron Trifluoride Etherate ◽  
Alternaria Brassicicola ◽  
Magnesium Bromide ◽  
Alternaria Brassicae ◽  
Analogous Reaction ◽  
Cyclocondensation Reaction

Treatment of (indol-1-yl)magnesium bromide or iodide with 2-bromoethyl isothiocyanate afforded 1-(4,5-dihydrothiazol-2-yl)indole (6). Analogous reaction with 2,2-dimethoxyethyl isothiocyanate led to corresponding 1-thiocarbamoylindole derivative (7), which was cyclized to 1-(5-methoxy-4,5-dihydrothiazol-2-yl)indole (8) by treatment with boron trifluoride etherate. New analogs of camalexin, namely 4',5'-dihydrocamalexin (12) and benzocamalexin (14) were prepared by cyclocondensation reaction of 1-(tert-butoxycarbonyl)indole-3-carbaldehyde with cysteamine and 2-aminobenzenethiol. Antifungal activity of the prepared compounds was studied, using the fungi Alternaria brassicae and Alternaria brassicicola.

Synthesis and Antifungal Activities of Some 2,6-Bis-(Un)Substituted Phenoxymethylpyridines

2010 ◽  
Vol 65 (7-8) ◽  
pp. 433-436
Author(s):  
Hui Xu ◽  
Huan Qu
Keyword(s):  
Antifungal Activity ◽  
Fusarium Oxysporum ◽  
Fusarium Graminearum ◽  
Broad Spectrum ◽  
Alternaria Alternata ◽  
Phytopathogenic Fungi ◽  
Alternaria Brassicae ◽  
Antifungal Activities

Several 2,6-bis-(un)substituted phenoxymethylpyridines were synthesized and evaluated in vitro against Fusarium graminearum, Helminthosporium sorokinianum, Alternaria brassicae, Alternaria alternata, and Fusarium oxysporum f. sp. vasinfectum. Among all derivatives, compound 3 a exhibited a broad-spectrum antifungal activity against the five phytopathogenic fungi.

scholarly journals Levantamento da intensidade da alternariose e da podridão negra em cultivos orgânicos de brássicas em Pernambuco e Santa Catarina

2006 ◽  
Vol 24 (4) ◽  
pp. 464-469 ◽  
Author(s):  
Luiz A M Peruch ◽  
Sami J Michereff ◽  
Issac B Araújo
Keyword(s):  
Xanthomonas Campestris ◽  
Alternaria Brassicicola ◽  
Alternaria Brassicae ◽  
Santa Catarina ◽  
Xanthomonas Campestris Pv Campestris

O objetivo deste trabalho foi avaliar a intensidade da alternariose, causada por Alternaria brassicicola e/ou Alternaria brassicae, e da podridão negra, causada por Xanthomonas campestris pv. campestris, em cultivos orgânicos de brássicas em Pernambuco e Santa Catarina. Os levantamentos foram realizados no período de novembro de 2001 a fevereiro de 2002, num total de 103 cultivos orgânicos de várias espécies de brássicas. Foram registradas elevadas prevalências das doenças nos estados, com exceção em couve-chinesa em Santa Catarina. A prevalência da alternariose foi 100% nos cultivos de brócolis em Pernambuco, bem como em couve-flor nos dois estados, enquanto a podridão negra atingiu esse nível nos cultivos de brócolis e couve-flor em Santa Catarina. Na média das diferentes espécies de brássicas, as doenças foram mais prevalentes em Pernambuco que Santa Catarina. Entretanto, as médias de severidade de cada doença no conjunto das brássicas não foram diferentes entre os estados, embora as condições climáticas tenham sido nitidamente distintas. A severidade da alternariose variou entre as espécies de brássicas somente em Pernambuco, com a menor severidade registrada em couve-manteiga. Em relação à podridão negra, apenas em Santa Catarina houve diferença na severidade entre as brássicas, sendo registrados os menores níveis em couve-chinesa. Não foram constatadas correlações significativas entre os níveis de severidade da alternariose e da podridão negra, bem como da severidade destas com o número total de plantas e a idade das plantas nos cultivos.

Incidence of Alternaria brassicicola (Schw.) Wiltsh. on Brassica oleracea seeds

1992 ◽  
Vol 32 (4) ◽  
pp. 535 ◽  
Author(s):  
A Sivapalan ◽  
JW Browning
Keyword(s):  
Brassica Oleracea ◽  
Primary Source ◽  
Alternaria Brassicicola ◽  
Alternaria Brassicae ◽  
Brassica Crops

Samples of Brassica oleracea seed from Victoria, were tested for the presence of seed-borne Alternaria brassicicola and Alternaria brassicae. A. brassicicola was detected in 26 of 44 samples tested but A. brassicae was not detected in any. Between 24 and 37% of seed was infected, with 4-8% of infection found in the embryo tissues. Inoculation of seed with A. brassicicola resulted in loss of vigour in germinated seedlings, followed by death. The fungus retained its viability and pathogenicity on seed stored for up to 12 months. This investigation indicates that a high proportion of commercially available brassica seed are contaminated with A. brassicicola and may therefore be a primary source of disease for brassica crops in Australia.

scholarly journals Antifungal Activity ofLactobacillussp. Bacteria in the Presence of Xylitol and Galactosyl-Xylitol

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Lidia Lipińska ◽  
Robert Klewicki ◽  
Elżbieta Klewicka ◽  
Krzysztof Kołodziejczyk ◽  
Michał Sójka ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Geotrichum Candidum ◽  
Antagonistic Activity ◽  
Indicator Strain ◽  
Alternaria Brassicicola ◽  
Acid Fermentation ◽  
Single Strain ◽  
Food Protection ◽  
Indicator Microorganisms ◽  
The Impact

Lactic acid fermentation is a natural method of antimicrobial food protection. Antagonistic activity ofLactobacillussp. bacteria, taking part in this process, is directed mainly against the same or other microorganisms. In this work we determine the impact of the presence of xylitol and galactosyl-xylitol on the antagonistic activity of 60Lactobacillussp. strains against indicator molds (Alternaria alternata,Alternaria brassicicola,Aspergillus niger,Fusarium latenicum,Geotrichum candidum, andMucor hiemalis) and yeasts (Candida vini). We used double-layer method to select antifungal strains ofLactobacillusbacteria and poisoned medium method to confirm their fungistatic properties. Additionally, we examined the inhibition ofAlternaria brassicicolabyLactobacillus paracaseiŁOCK 0921 cultivated with xylitol or galactosyl-xylitol directly on wild cherries. The presence of xylitol and its galactosyl derivative led to increase of spectrum of antifungal activity in most of the studied plant-associated lactobacilli strains. However, no single strain exhibited activity against all the indicator microorganisms. The antifungal activity ofLactobacillusbacteria against molds varied considerably and depended on both the indicator strain and the composition of the medium. The presence of xylitol and galactosyl-xylitol in the growth medium is correlated with the antifungal activity of the studiedLactobacillussp. bacteria against selected indicator molds.

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