Reactions of α,β-unsaturated ketones with arylacetonitriles

1987 ◽  
Vol 52 (4) ◽  
pp. 1021-1025 ◽  
Author(s):  
Mohammad M. Al-Arab ◽  
Ali M. Issa
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Room Temperature ◽  
Sodium Ethoxide ◽  
Reaction Products ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Unsaturated Ketones ◽  
Single Diastereomer ◽  
Lanthanide Shift Reagents ◽  
Diastereomeric Purity

1,3-Diaryl-2-propene-1-ones I react with arylacetonitriles II in the presence of sodium ethoxide at room temperature to give a single diastereomer of the corresponding 2,3-diaryl-4-aroylbutyronitriles III. The structures of the reaction products were established by infrared, nuclear magnetic resonance, and mass spectral data as well as elemental analysis. The diastereomeric purity was determined by NMR measurements using lanthanide shift reagents. The observed resonances did not show any resolved diastereomeric proton signals.

scholarly journals Chemical Constituents of Phoebe poilanei and Their Cytotoxic Activity

2019 ◽  
Vol 14 (5) ◽  
pp. 1934578X1985096
Author(s):  
Nguyen Thi Viet Thanh ◽  
Tran Thi Minh ◽  
Dinh Thi Thu Hien ◽  
Ho Duc Cuong ◽  
Yohan Seo ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
High Resolution ◽  
Cytotoxic Activity ◽  
Spectral Data ◽  
Chemical Constituents ◽  
Flavonol Glycosides ◽  
Ionization Mass ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Chemical Structures

Two new flavonol glycosides, rhamnocitrin 3- O-α-L-rhamnopyranosyl-(1→6)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside (1) and quercetin 3- O-6- Z- p-coumaroyl-β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranoside (2), along with 3 flavonol glycosides, isoquercitrin (3), rutin (4), and quercetin 3- O-α-L-rhamnopyranosyl-(1→6)-β-D-galactopyranoside (5), and two known sesquiterpenes, alismol (6) and spathulenol (7), were isolated from the leaves of Phoebe poilanei Kosterm. Their chemical structures were elucidated by analyses of their high-resolution electrospray ionization mass spectral data and nuclear magnetic resonance spectral data and comparison with those reported in the literature. Two sesquiterpenes 6 and 7 were found to exhibit moderate cytotoxic activity with IC50 values ranging from 21.6 to 29.8 µM.

Cyclopropanes of 5-nitrofuran series

1979 ◽  
Vol 44 (2) ◽  
pp. 420-423 ◽  
Author(s):  
Josef Prousek ◽  
Adolf Jurášek ◽  
Miloslava Dandárová ◽  
Jaroslav Kováč
Keyword(s):  
Spectral Data ◽  
Reaction Products ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr

5-Nitrofurfuryl trichloromethyl sulphone (I) was reacted with paraformaldehyde in methanol in the presence of piperidine as catalyst to give 1-(5-nitro-2-furyl)-1-trichloromethylsulphonyl-2-(5-nitro-2-furyl)cyclopropane. This substance was also obtained from 1-(5-nitro-2-furyl)-1-trichloromethylsulphonyl-2-(5-nitro-2-furyl)ethylene and diazomethane. The reaction products were characterized by IR, UV, 1H NMR and mass spectral data.

scholarly journals N-[2-(1H-Indol-3-yl)ethyl]-2-(4-isobutylphenyl)propanamide

Molbank ◽  
10.3390/m1031 ◽  
2018 ◽  
Vol 2018 (4) ◽  
pp. M1031
Author(s):  
Stanimir Manolov ◽  
Iliyan Ivanov ◽  
Yulian Voynikov
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Spectral Data ◽  
1H Nmr ◽  
13C Nmr ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Nuclear Magnetic

The compound in the title was prepared by reaction between tryptamine and ibuprofen using N,N′-dicyclohexylcarbodiimide as a “dehydrating” reagent. The structure of the newly synthesized compound was determined by nuclear magnetic resonance (NMR) (1H-NMR and 13C-NMR), UV, IR, and mass spectral data.

Synthesis and Characterization of Some Dibasic Tridentate Schiff Base Ligands

1975 ◽  
Vol 53 (6) ◽  
pp. 939-944 ◽  
Author(s):  
Elmer C. Alyea ◽  
Abdul Malek
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Schiff Base ◽  
Magnetic Resonance ◽  
Synthesis And Characterization ◽  
Mass Spectral Data ◽  
Schiff Base Ligands ◽  
Mass Spectral ◽  
Structural Formulas ◽  
Tridentate Schiff Base

The synthesis and characterisation of several dibasic tridentate Schiff base ligands (H2SB) are described. Structural formulas for the isolated ligands are suggested on the basis of infrared, nuclear magnetic resonance, and mass spectral data.

scholarly journals Zinc Triflate Promoted General Synthetic Protocol for the Facile Construction of Chromenes and Pyrimidines Bearing N-Allyl Quinolone Nucleus

2015 ◽  
Vol 47 ◽  
pp. 199-207
Author(s):  
Nileshkumar D. Vala ◽  
Hardik H. Jardosh ◽  
Manish P. Patel
Keyword(s):  
Elemental Analysis ◽  
13C Nmr ◽  
Room Temperature ◽  
Mass Spectral Data ◽  
One Pot ◽  
Mass Spectral ◽  
Cyclocondensation Reaction ◽  
Ft Ir ◽  
Derivatives Of ◽  
Zinc Triflate

A series of 8 derivatives of chromene 5a-h synthesized via one-pot cyclocondensation reaction of N-allyl quinolones, α/β naphthol and malononitrile. And 8 derivatives of pyrimidines 8a-h bearing N-allyl quinolone have been synthesized by N-allyl quinolones, ethylacetoacetate, thiourea/urea in the presence of zinc triflate as less toxic catalyst. This methodology allowed the high conversion of product at room temperature. Titled derivatives were elucidated by FT-IR, 1H NMR, 13C NMR, elemental analysis, and mass spectral data.

scholarly journals MONOMER STILBENOID GLUCOSIDES FROM Vatica pauciflora AND Vatica lowii (DIPTEROCARPACEAE)

2015 ◽  
Vol 77 (2) ◽  
Author(s):  
Aisyah Salihah Kamarozaman ◽  
Jalifah Latip ◽  
Christian Paetz ◽  
Yana M. Syah
Keyword(s):  
Liquid Chromatography ◽  
High Performance ◽  
Room Temperature ◽  
Methanolic Extract ◽  
Pure Compound ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Soxhlet Apparatus ◽  
Vacuum Liquid Chromatography ◽  
Phytochemical Studies

Phytochemical studies on the woods of Vatica pauciflora and Vatica lowii have been conducted. The woods of V. pauciflora were extracted with methanol by using Soxhlet apparatus while the woods of V. lowii were extracted with acetone at room temperature. The methanolic extract of V. pauciflora was semi-purified by using vacuum liquid chromatography (VLC) and further purified by high performance liquid chromatography (HPLC) to obtain a pure compound (1). The same technique of semi-purification has been employed on V. lowii acetone extract which was further purified by radial chromatography to give a pure compound (2). Based on the UV, IR, NMR and mass spectral data, the isolated compounds were characterized as (-)-cis-resveratrol-10-C-b-D-glucopyranoside and (-)-piceid respectively.

Friedel–Crafts alkylation of benzene with 1,1-d2-1-chloropropane

1970 ◽  
Vol 48 (5) ◽  
pp. 858-862 ◽  
Author(s):  
C. C. Lee ◽  
D. J. Woodcock
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Spectral Data ◽  
Reaction Medium ◽  
Side Chain ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Alkylation Of Benzene ◽  
Nuclear Magnetic

The AlCl3 catalyzed reaction of 1,1-d2-1-chloropropane with benzene was carried out in excess benzene at about 5° or in 1,2,4-trichlorobenzene as solvent at 0°. The products, n-propylbenzene and isopropylbenzene, were examined by nuclear magnetic resonance and mass spectrometry. The results indicated only very minor amounts of isotope position scrambling in the propyl side chain, suggesting no major involvement of protonated cyclopropane intermediates in the reaction. The mass spectral data, however, demonstrated that the products are quite labile in the reaction medium, with extensive intermolecular hydride and deuteride transfers taking place.

High-throughput microcomputer-based binary-coded search systems for infrared, carbon-13 nuclear magnetic resonance, and mass spectral data

1982 ◽  
Vol 54 (11) ◽  
pp. 1772-1777 ◽  
Author(s):  
Alan P. Uthman ◽  
Jerry P. Koontz ◽  
Judy. Hinderliter-Smith ◽  
W. Stephen. Woodward ◽  
Charles N. Reilley
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Spectral Data ◽  
High Throughput ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Nuclear Magnetic ◽  
Search Systems

The hex-5-enose degradation: cleavage of glycosiduronic acid linkages in modified methylated Sterculia gums

1987 ◽  
Vol 65 (9) ◽  
pp. 2069-2076 ◽  
Author(s):  
Gerald Oliver Aspinall ◽  
Lev Khondo ◽  
Bruce Alan Williams
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Galacturonic Acid ◽  
Uronic Acid ◽  
Zinc Dust ◽  
Degradation Products ◽  
Compositional Analysis ◽  
Mass Spectral Data ◽  
Mass Spectral

Reduction of uronic acid residues in permethylated polysaccharides from Sterculiaurens and S. caudata gums, followed by transformation of the resulting hexose into 6-deoxy-6-iodohexose residues, affords modified polysaccharides that undergo depolymerization on treatment with zinc dust. The main products after reduction with sodium borohydride are hexenitolterminated oligosaccharides. Their structures have been assigned as members of a series of O-[α-L-rhamnopyranosyl]-(1 → 3)-1,2-dideoxyhex-1-enitol derivatives, with and without attendant β-D-galactopyranosyl substituents, on the basis of nuclear magnetic resonance and mass spectral data and compositional analysis of trideuteriomethylated derivatives. The structures of the polysaccharides have been reassessed in the light of these and other experiments, and may now be formulated as containing a backbone of alternating 4-linked α-D-galacturonic acid and 2-linked α-L-rhamnopyranose residues bearing a minimum of three types of side chains attached at specific sites. Characterization of some of the degradation products provides evidence that limited degradation had occurred during methylation of the glycuronans.

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