11-(Dimethylaminoalkyl)-6,11-dihydrodibenzo[b,e]thiepin-11-carbonitriles and some related compounds

1983 ◽  
Vol 48 (7) ◽  
pp. 1898-1909 ◽  
Author(s):  
Karel Šindelář ◽  
Jiří Holubek ◽  
Miroslav Ryska ◽  
Emil Svátek ◽  
Jiří Urban ◽  
...  
Keyword(s):  
Amino Acid ◽  
Potassium Hydroxide ◽  
Main Product ◽  
Sodium Hydride ◽  
Neurotropic Activity ◽  
Amide Hydrolysis ◽  
Hydrolysis Of ◽  
Related Compounds ◽  
Benzyltriethylammonium Chloride ◽  
Sodium Amide

The title compounds II and III were obtained by alkylations of 6,11-dihydrodibenzo[b,e]thiepin-11-carbonitrile (I) with 2-dimethylaminoethyl chloride and 3-dimethylaminopropyl chloride in the presence of sodium hydride or sodium amide. Hydrolysis of the nitrile II with potassium hydroxide in ethanol resulted in a small amount of the amino acid X and in the amine XI as the main product. Alkylations of I with 1,2-dibromoethane and 1,3-dibromopropane in the presence of sodium hydride gave the bromoalkylnitriles IV and V and the alkylenebisnitriles XIII and XIV. The preparation of the methylpiperazinopropyl derivative VI proved the usefulness of compounds IV and V in the synthesis of further aminonitriles of this series. Alkylation of the nitrile I with 1,2-dibromoethane in the presence of sodium hydroxide or potassium carbonate and benzyltriethylammonium chloride afforded three isomeric nitriles C17H13NS: the vinyl derivative IX, the 6,11-ethano-6H, 11H-dibenzo[b,e]thiepin derivative XV and finally the 1a,11b-dihydro-1H,7H-dibenzo[b,f]cyclopropa[d]thiocin derivative XVI. Compounds II, III, VI and XII showed some spasmolytic effects but their central neurotropic activity is insignificant.

Synthesis of Some 2'-C-Alkyl Derivatives of 9-(2-Phosphonomethoxyethyl)adenine and Related Compounds

1994 ◽  
Vol 59 (9) ◽  
pp. 2069-2094 ◽  
Author(s):  
Hana Dvořáková ◽  
Antonín Holý ◽  
Ivan Rosenberg
Keyword(s):  
Reaction Pathway ◽  
Sodium Hydride ◽  
Amino Group ◽  
Trimethylsilyl Derivative ◽  
Phosphonic Acids ◽  
Alkyl Derivatives ◽  
Hydrolysis Of ◽  
Trifluoromethyl Derivative ◽  
Derivatives Of ◽  
Related Compounds

To study the effect of β-substitution in 2'-alkyl derivatives of 9-(2-phosphonomethoxyethyl)adenine (Ia) on the antiviral activity or group specificity, these derivatives were synthesized. 9-(2-Hydroxyalkyl)adenines VIII were prepared by alkylation of adenine with suitably substituted oxiranes XIII or 2-hydroxyalkyl p-toluenesulfonates IV and VI. After protection of the adenine amino group by benzoylation (compounds IX) or amidine formation (compounds X), the intermediates were alkylated with diisopropyl p-toluenesulfonyloxymethanephosphonate (XI) in the presence of sodium hydride. After deprotection, the obtained phosphonate diesters XII were converted into phosphonic acids I by transsilylation and hydrolysis. This synthetic scheme was used for the preparation of ethyl (Ie), propyl (If), 2-propyl (Ig), 2-methylpropyl (Ih), cyclopropyl (Ii), cyclohexyl (Ij), benzyl (Ik) and phenyl (Il) derivatives. The 2'-trifluoromethyl derivative XXIIa was prepared analogously from 9-(2-hydroxy-3,3,3-trifluoropropyl)adenine (XXa), obtained by alkylation of adenine sodium salt with 2-hydroxy-3,3,3-trifluoropropyl bromide. 2'-Trimethylsilyl derivative XIXa was obtained by alkylation of adenine with 2-diisopropylphosphonomethoxy-3-(4-toluenesulfonyloxy)propyltrimethylsilane (XVII) followed by transsilylation and hydrolysis of diester XVIIIa. 2,6-Diaminopurine derivatives XVIIId and XXIIb were obtained analogously. 9-(3-Phosphonomethoxybutyl)adenine (XXVIII) and 9-(2-methyl-2-phosphonomethoxypropyl)adenine (XXXV) were prepared from the corresponding hydroxy derivatives XXVIb and XXXII, respectively, by the same reaction pathway as derivatives I.

Dibenzo[b,f]thiepin-10-carbonitrile, its 10,11-dihydro derivative, some transformation products and related compounds

1983 ◽  
Vol 48 (4) ◽  
pp. 1187-1211 ◽  
Author(s):  
Karel Šindelář ◽  
Jiří Holubek ◽  
Miroslav Ryska ◽  
Emil Svátek ◽  
Jiří Urban ◽  
...  
Keyword(s):  
Main Product ◽  
Cardiovascular Effects ◽  
Transformation Products ◽  
Anticonvulsant Effect ◽  
Cuprous Cyanide ◽  
High Doses ◽  
Hydrolysis Of ◽  
Related Compounds ◽  
By Products ◽  
Dichloro Derivative

Reactions of 10-bromodibenzo[b,f]thiepin (IIIa), its 2-chloro derivative IIIb and 2,8-dichloro derivative IIIc with cuprous cyanide in boiling dimethylformamide gave the carbonitriles Iabc out of which the first two were reduced with sodium borohydride to the 10,11-dihydro derivatives IVab; the amides VIIab were obtained as by-products. Alkaline hydrolysis of the nitriles IVab or their mixtures with the amides VIIab afforded the acids VIIIab. By the addition of 3-dimethylaminopropylmagnesium chloride to the nitrile Ia cis and trans-11-(3-dimethylaminopropyl)-10,11-dihydrodibenzo[b,f]thiepin-10-carbonitriles (XVIII) were obtained. Alkylation of the nitrile IVa with 2-dimethylaminoethyl chloride and 3-dimethylaminopropyl chloride resulted in the 10-(dimethylaminoalkyl) derivatives XX and XXI. A reaction of the crude cyano alcohol XXIII with phosphorus tribromide afforded the 2-bromoethyl derivative XXIV as a by-product only. The main product was the hydrobromide of the spirocyclic imidate XXX which affords by acid hydrolysis the spirocyclic lactone XXXI. An analogous sequence proceeding via the ether XXVI and the alcohol XXVII leads to the 10-(3-bromopropyl) derivative XXVIII as the main product. An attempt at preparing the same substance by alkylation of the nitrile IVa with 1,3-dibromopropane gave stereoisomeric dinitriles XXXII. At high doses the amides VIIab reveal an anticonvulsant effect, the acids VIIIab antiinflammatory actions, the basic nitrile cis-XVIII antireserpine activity and the basic nitriles XX and XXI a central depressant and pseudo-analgesic activity in addition to further peripheral and cardiovascular effects.

Nucleic Acid Related Compounds. 14. 3′-O-Aminoacyl-2′-O-methyladenosines and 2′-O-Aminoacyl-3′-O-methyladenosines Related to Charged tRNA Termini

1974 ◽  
Vol 52 (22) ◽  
pp. 3803-3813 ◽  
Author(s):  
Morris J. Robins ◽  
Malcolm MacCoss ◽  
G. Ramani
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Nucleic Acid ◽  
Protein Biosynthesis ◽  
Glycosidic Bonds ◽  
Acid Anhydrides ◽  
High Yields ◽  
First Time ◽  
Hydrolysis Of ◽  
Related Compounds

Aminoacyl nucleosides derived from 2′-O-methyladenosine and 3′-O-methyladenosine have been isolated as pure solids and completely characterized for the first time. Coupling of 5′-O-(mono-p-methoxytrityl)-2′-O-methyl- (and 3′-O-methyl-) adenosines (1 and 6, respectively) with N-tert-butyloxycarbonyl(N-tBOC)-amino acid anhydrides (2a–c) (generated insitu from the corresponding N-tBOC-amino acids and N,N′-dicyclohexylcarbodiimide) in the presence of 4-N,N-dimethylaminopyridine gave the 3′-O-(N-tBOC-aminoacyl)-5′-O-(mono-p-methoxytrityl-2′-O-methyladenosines (3a–c) and 2′-O-(N-tBOC-aminoacyl)-5′-O-(mono-p-methoxytrityl-3′-O-methyladenosines (7a–c), respectively, in good yields. The L-leucine (a), L-phenylalanine (b), and L-methionine (c) compounds were prepared in each series. Complete deblocking was effected using 98% formic acid since usual procedures had disadvantages with these molecules. The 3′-O-(L-aminoacyl)-2′-O-methyladenosines (4a–c) and 2′-O-(L-aminoacyl)-3′-O-methyladenosines (8a–c) were obtained in high yields with no detectable hydrolysis of the aminoacyl or glycosidic bonds under these conditions.N-Formylmethionyl and N-acetylphenylalanyl derivatives were prepared in each series by acylation of the deblocked products with acetic formic anhydride and p-nitrophenyl acetate, respectively. Biochemical rationale for the use of these compounds in the study of protein biosynthesis and initiation processes are discussed. The puromycin-like activity of 3′-O-phenylalanyl-2′-O-methyl-adenosine (4b) was confirmed.

The Stereochemistry of the Reformatsky Reaction of Methyl 4-Bromo-3-methylbut-2-enoate with β-Cyclocitral and Related Compounds

1975 ◽  
Vol 53 (13) ◽  
pp. 1943-1948 ◽  
Author(s):  
R. N. Gedye ◽  
Parkash Arora ◽  
A. H. Khalil
Keyword(s):  
Wittig Reaction ◽  
Main Product ◽  
Reformatsky Reaction ◽  
Reformatsky Reactions ◽  
Hydrolysis Of ◽  
Related Compounds ◽  
The Reformatsky Reaction

Both methyl Z- and E-4-bromo-3-methylbut-2-enoate react with β-cyclocitral in the presence of zinc to give the δ-lactone of 5-hydroxy-3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-pentenoic acid as the main product, indicating an E to Z inversion during the Reformatsky reaction. Similar results were obtained in the Reformatsky reactions of the Z- and E-bromo-esters with benzaldehyde and cyclohexenecarboxaldehyde. Here hydrolysis of the Reformatsky product gave, in each case, the corresponding Z-2,E-4-acids as the main products, indicating the formation of the δ-lactone as an intermediate. The synthesis of Z- and E-β-ionylideneacetic acid and the corresponding ring demethyl analogs using a Wittig reaction is also described.

Synthesis of 9-(2-phosphonylmethoxyethyl)adenine and related compounds

1987 ◽  
Vol 52 (11) ◽  
pp. 2801-2809 ◽  
Author(s):  
Antonín Holý ◽  
Ivan Rosenberg
Keyword(s):  
Methyl Ester ◽  
Ethyl Ester ◽  
Sodium Salt ◽  
Alkaline Hydrolysis ◽  
Inorganic Phosphate ◽  
Sodium Hydride ◽  
Analogous Reaction ◽  
Hydrolysis Of ◽  
Related Compounds

Diethyl 2-hydroxyethoxymethanephosphonate (VIII) was converted into diethyl 2-halogenoethoxymethanephosphonates IXa and IXb by reaction with triphenylphosphine and tetrachloromethane or tetrabromomethane; analogous reaction of VIII with p-toluenesulfonyl chloride afforded diethyl 2-(p-toluenesulfonyloxy)ethoxymethanephosphonate (IXc). Reaction of sodium salt of adenine with compounds IX led to 9-(2-diethoxyphosphonylmethoxyethyl)adenine (X). Compound X was converted into 9-(2-phosphonylmethoxyethyl)adenine (II) by treatment with bromotrimethylsilane whereas alkaline hydrolysis of X gave ethyl ester Vb. Reaction of 9-(2-hydroxyethyl)adenine (IIIa) or its N6-benzoyl derivative IIIb with dimethyl p-toluenesulfonyloxymethanephosphonate (IV) in the presence of sodium hydride, followed by alkaline hydrolysis yielded methyl ester Va. Morpholide XI reacted with an inorganic phosphate and diphosphate to give 9-(2-phosphorylphosphonylmethoxyethyl)adenine (XII) and 2-(diphosphorylphosphonylmethoxyethyl)adenine (XIII), respectively.

scholarly journals Novel Amino Acid Derivatives of Quinolines as Potential Antibacterial and Fluorophore Agents

2020 ◽  
Vol 88 (4) ◽  
pp. 57
Author(s):  
Oussama Moussaoui ◽  
Rajendra Bhadane ◽  
Riham Sghyar ◽  
El Mestafa El Hadrami ◽  
Soukaina El Amrani ◽  
...  
Keyword(s):  
Amino Acid ◽  
Methyl Esters ◽  
Amino Acid Derivatives ◽  
Bacterial Strains ◽  
Fluorescent Properties ◽  
Topoisomerase Iv ◽  
Microdilution Method ◽  
Hydrolysis Of ◽  
Derivatives Of

A new series of amino acid derivatives of quinolines was synthesized through the hydrolysis of amino acid methyl esters of quinoline carboxamides with alkali hydroxide. The compounds were purified on silica gel by column chromatography and further characterized by TLC, NMR and ESI-TOF mass spectrometry. All compounds were screened for in vitro antimicrobial activity against different bacterial strains using the microdilution method. Most of the synthesized amino acid-quinolines show more potent or equipotent inhibitory action against the tested bacteria than their correspond esters. In addition, many of them exhibit fluorescent properties and could possibly be utilized as fluorophores. Molecular docking and simulation studies of the compounds at putative bacterial target enzymes suggest that the antimicrobial potency of these synthesized analogues could be due to enzyme inhibition via their favorable binding at the fluoroquinolone binding site at the GyrA subunit of DNA gyrase and/or the ParC subunit of topoisomerase-IV.

Synthesis and Tautomerism of Curcumin Derivatives and Related Compounds

2015 ◽  
Vol 68 (2) ◽  
pp. 224 ◽  
Author(s):  
Hiroyasu Taguchi ◽  
Daijiro Yanagisawa ◽  
Shigehiro Morikawa ◽  
Koichi Hirao ◽  
Nobuaki Shirai ◽  
...  
Keyword(s):  
Parent Compound ◽  
Amyloid Plaques ◽  
Enol Form ◽  
19F Nmr ◽  
Enolic Form ◽  
Curcumin Derivatives ◽  
Alkyl Groups ◽  
Alzheimer Brain ◽  
Hydrolysis Of ◽  
Related Compounds

1,7-Bis(4′-hydroxy-3′-trifluoromethoxyphenyl)-1,6-heptadiene-3,5-dione (2a), related to curcumin, and thirteen 4-substituted derivatives were prepared and their keto/enol ratio in DMSO[D6] was determined by 19F NMR because the enolic form of these related curcumins had been shown to bind to amyloid plaques in the Alzheimer brain. The parent compound and the 4-ethoxycarbonyl derivative were almost 100 % in the enolic form that contains a conjugated hepta-1,4,6-trien-3-on-5-ol backbone. Enolisation decreased to varying amounts in the derivatives that had 4-substituted alkyl groups. Attempts to prepare the 4-hydroxypropyl derivative by hydrolysis of O-methoxymethyl 2m or O-tetrahydropyranyloxy 2n protected derivatives led to cyclised products. A related pyrimidine compound 6b that mimicked a fixed enol form was also prepared.

Cyclic amidines derived from benz[c,d]indole and 4,5-dihydro-3H-1-benzazepine including some related compounds: Synthesis and pharmacological screening

1985 ◽  
Vol 50 (8) ◽  
pp. 1888-1898 ◽  
Author(s):  
Miroslav Protiva ◽  
Zdeněk Šedivý ◽  
Jiří Holubek ◽  
Emil Svátek ◽  
Jiří Němec
Keyword(s):  
Titanium Tetrachloride ◽  
Aqueous Sodium Hydroxide ◽  
Secondary Amines ◽  
Primary Amines ◽  
Open Chain ◽  
Lithium Aluminium ◽  
Pharmacological Screening ◽  
Antiinflammatory Effects ◽  
Related Compounds ◽  
Sodium Amide

Reactions of naphthostyril (I) with primary and secondary amines and titanium tetrachloride afforded cyclic amidines III-IX. Hydrogenation of I on Pd-C resulted in the 6,7,8,8a-tetrahydro derivative X which gave by treatment with sodium amide and 3-dimethylaminopropyl chloride the N-(aminoalkyl) compound XI. Reduction of I and its N-methyl derivative II with sodium amalgam in aqueous sodium hydroxide gave the 2a,3,4,5-tetrahydro derivatives XII and XIII. Reaction of XIII with sodium amide and 3-dimethylaminopropyl chloride afforded the 2a-(aminoalkyl) compound XIV. 1,3,4,5-Tetrahydro-1-benzazepin-2-one (XV) treated with primary amines and titanium tetrachloride gave the amidines XVI-XVIII. 3-Methyl-7,8,9,9a-tetrahydro-1H-benz[d,e]isoquinoline (XIX) was reduced with sodium borohydride to compound XX which was alkylated with propargyl bromide to 1-methyl-2-propargyl-2,3,3a,4,5,6-hexahydro-1H-benz[d,e]isoquinoline (XXI). An attempt to prepare the 2-(2-phenylethyl) analogue by treatment of compound XX with phenylacetyl chloride and by the following reduction with lithium aluminium hydride resulted in the open-chain amine XXII. The lactams I, II, X, and XIII showed some discoordinating, hypothermic, peripheral vasodilating, hyperglycaemic, diuretic and antiinflammatory effects. The amidines III-IX and XVI-XVIII had local anaesthetic, slight hypotensive, antiarrhythmic, peripheral myorelaxant, papaverine-like spasmolytic and thiopental potentiating effects.

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