Alkylation of ergoline derivatives at position N(1)

1982 ◽  
Vol 47 (2) ◽  
pp. 622-624 ◽  
Author(s):  
Jan Šmidrkal ◽  
Miroslav Semonský
Keyword(s):  
Potassium Hydroxide ◽  
Alkyl Halides ◽  
Dimethyl Sulphoxide

N(1)-Alkyl-8β-ergolines I-XII were prepared by alkylation of 8β-ergoline derivatives XIII to XVIII with alkyl halides in dimethyl sulphoxide in the presence of potassium hydroxide. The compounds I-XII exhibited weak inhibition effects on the secretion of prolactin

One-Pot Synthesis of Oxime Ethers from Benzaldehyde or Acetophenone, Hydroxylamine Salt, Potassium Hydroxide, and Alkyl Halides.

ChemInform ◽  
2003 ◽  
Vol 34 (30) ◽  
Author(s):  
Chunbao Li ◽  
Hang Zhang ◽  
Yi Cui ◽  
Shuanming Zhang ◽  
Zheyuan Zhao ◽  
...  
Keyword(s):  
Potassium Hydroxide ◽  
Alkyl Halides ◽  
One Pot ◽  
One Pot Synthesis

Synthesis of Double Alkyl EO/PO Random Copolyethers with KOH Catalyst

2012 ◽  
Vol 472-475 ◽  
pp. 2681-2685
Author(s):  
Jian Guo Guo ◽  
Su Qin He ◽  
Jian Ming Jiang
Keyword(s):  
Molecular Weight ◽  
Ethylene Oxide ◽  
Propylene Oxide ◽  
Potassium Hydroxide ◽  
Random Copolymer ◽  
Alkyl Halides ◽  
Ethyl Bromide ◽  
Hydroxyl Group ◽  
Molar Ratio ◽  
End Capping

Ethylene oxide (EO) and propylene oxide (PO) random copolymer was synthesized with 1,2-propanediol as initiator, then the end-capping process was carried out by adding various alkyl halides and potassium hydroxide (KOH) to produce the double alkyl EO/PO random copolyethers. The factors effecting alkyl-capping rate were discussed. The results showed that when the molar ratio of hydroxyl group/KOH/1-bromobutane was 1/1.9/1.9, reacting time 6.5 hr and reacting temperature 50°C, the alkyl-capping rate could reach over 80%. The end-capping rate would also increase with the increasing content of ethylene oxide in the random polyether, and the end-capping rate of the EO/PO/EO block-polyether was high than that of the random polyether with same molecular weight. Instead of 1-bromobutane, ethyl bromide promised a higher whereas chloralkane gave a lower end-capping rate respectively.

Synthesis of Simple Unsymmetrical Ethers from Alcohols and Alkyl Halides or Sulfates: The Potassium Hydroxide/Dimethyl Sulfoxide System

Synthesis ◽  
1979 ◽  
Vol 1979 (06) ◽  
pp. 428-429 ◽  
Author(s):  
David R. Benedict ◽  
Thomas A. Bianchi ◽  
Laurence A. Cate
Keyword(s):  
Dimethyl Sulfoxide ◽  
Potassium Hydroxide ◽  
Alkyl Halides

User-friendly aerobic reductive alkylation of iridium(iii) porphyrin chloride with potassium hydroxide: scope and mechanism

2015 ◽  
Vol 44 (47) ◽  
pp. 20618-20625 ◽  
Author(s):  
Huiping Zuo ◽  
Zhipeng Liu ◽  
Wu Yang ◽  
Zhikuan Zhou ◽  
Kin Shing Chan
Keyword(s):  
Potassium Hydroxide ◽  
Reducing Agent ◽  
Alkyl Halides ◽  
Reductive Alkylation ◽  
Carbonyl Chloride ◽  
User Friendly

Alkylation of iridium 5,10,15,20-tetrakistolylporphyrinato carbonyl chloride, Ir(ttp)Cl(CO) (1), with 1°, 2° alkyl halides was achieved to give (ttp)Ir-alkyls in good yields under air and water compatible conditions by utilizing KOH as the cheap reducing agent.

ChemInform Abstract: N-Alkylations of NH-Sulfoximines and NH-Sulfondiimines with Alkyl Halides Mediated by Potassium Hydroxide in Dimethyl Sulfoxide.

ChemInform ◽  
2014 ◽  
Vol 45 (45) ◽  
pp. no-no
Author(s):  
Christine M. M. Hendriks ◽  
Rebekka A. Bohmann ◽  
Marina Bohlem ◽  
Carsten Bolm
Keyword(s):  
Dimethyl Sulfoxide ◽  
Potassium Hydroxide ◽  
Alkyl Halides

N-Alkylations ofNH-Sulfoximines andNH-Sulfondiimines with Alkyl Halides Mediated by Potassium Hydroxide in Dimethyl Sulfoxide

2014 ◽  
Vol 356 (8) ◽  
pp. 1847-1852 ◽  
Author(s):  
Christine M. M. Hendriks ◽  
Rebekka A. Bohmann ◽  
Marina Bohlem ◽  
Carsten Bolm
Keyword(s):  
Dimethyl Sulfoxide ◽  
Potassium Hydroxide ◽  
Alkyl Halides

scholarly journals New spectrophotometric methods for the determination of nifedipine in pharmaceutical formulations.

2005 ◽  
Vol 52 (4) ◽  
pp. 915-922 ◽  
Author(s):  
Nafisur Rahman ◽  
Syed Najmul Hejaz Azmi
Keyword(s):  
Nitro Group ◽  
Potassium Hydroxide ◽  
Pharmaceutical Formulations ◽  
Ammonium Molybdate ◽  
Dimethyl Sulphoxide ◽  
Hypothesis Tests ◽  
Molybdenum Blue ◽  
Spectrophotometric Methods ◽  
Beer’S Law

Two simple, sensitive and economical spectrophotometric methods were developed for the determination of nifedipine in pharmaceutical formulations. Method A is based on the reaction of the nitro group of the drug with potassium hydroxide in dimethyl sulphoxide (DMSO) medium to form a coloured product, which absorbs maximally at 430 nm. Method B uses oxidation of the drug with ammonium molybdate and subsequently reduced molybdenum blue is measured at 830 nm. Beer's law is obeyed in the concentration range of 5.0-50.0 and 2.5-45.0 microg ml(-1) with methods A and B, respectively. Both methods have been successfully applied for the assay of the drug in pharmaceutical formulations. No interference was observed from common pharmaceutical adjuvants. The reliability and the performance of the proposed methods are established by point and interval hypothesis tests and through recovery studies.

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