Some derivatives of 4-aryl-2,3-dicyano-1-naphthol

1981 ◽  
Vol 46 (6) ◽  
pp. 1523-1529 ◽  
Author(s):  
Jiří Křepelka ◽  
Iva Vančurová ◽  
Jiří Holubek
Keyword(s):  
Spectral Methods ◽  
Aluminium Chloride ◽  
Partial Substitution ◽  
Anhydrous Aluminium Chloride ◽  
Antineoplastic Effect ◽  
Derivatives Of

Reactions of vicinal aromatic dibromo derivatives Ia-d with the system copper(I) cyanide-tetramethylurea gave the vicinal dicyano derivatives IIa-d; products of partial substitution, Va-d, demethylation and deacetylation, IIIa-c, were also formed. The compounds IIIa-c were also prepared by direct demethylation of compounds IIa-c with the system anhydrous aluminium chloride-dichloroethane. The structures of selected compounds were determined by spectral methods. Compounds IIa-d have proved to have a moderate antineoplastic effect in animals with some transplantable experimental tumours.

scholarly journals Synthesis of 3-Ferrocenyl Isocoumarins

2020 ◽  
Vol 36 (05) ◽  
pp. 976-979
Author(s):  
Neeta Sinha
Keyword(s):  
Spectral Analysis ◽  
Melting Point ◽  
Phosphoric Acid ◽  
Polyphosphoric Acid ◽  
Aluminium Chloride ◽  
Melting Point Determination ◽  
Anhydrous Aluminium Chloride ◽  
Point Determination ◽  
Derivatives Of

The derivatives of 3-ferrocenyl isocoumarin were synthesized by the condensation of substituted homothphalic anhydride with ferrocene using phosphoric acid or anhydrous aluminium chloride as cyclising agent. Substituted homophthalic acid did not condense with ferrocene so homophthalic acids were converted into their anhydride and then allowed to react with ferrocene in the presence of polyphosphoric acid or in the presence of anhydrous aluminium chloride using dichloromethane as the solvent to give 3-ferrocenyl isocoumarins. 7-Methoxy, 6-methyl, 5,7-dihydroxy, 6,7-dimethoxy and 5,7-dimethoxy derivatives of 3-ferrocenyl isocoumarin were synthesized. All the compounds were characterised by melting point determination, elemental and spectral analysis.

Some ω-(2-amino-6-hydroxy-4-oxo-3,4-dihydro-5-pyrimidinyl) alkanoic acids, their derivatives and analogues

1980 ◽  
Vol 45 (12) ◽  
pp. 3583-3592 ◽  
Author(s):  
Miroslav Semonský ◽  
Antonín Černý ◽  
Jiří Křepelka ◽  
Rudolf Kotva ◽  
Bohumil Kakáč ◽  
...  
Keyword(s):  
Ethyl Ester ◽  
Spectral Methods ◽  
Barbituric Acid ◽  
Thiobarbituric Acid ◽  
Point Of View ◽  
Antineoplastic Effect ◽  
Alkanoic Acids ◽  
Derivatives Of ◽  
Acyl Derivatives

Condensation of 1,1,ω-alkanetricarboxylic acids triethyl esters XIV-XXI with guanidine gave ω-(2-amino-6-hydroxy-4-oxo-3,4-dihydro-5-pyrimidinyl) alkanoic acids I-IV, VI-VIII, XIII of which some were converted to derivatives (ethyl ester V, N-acyl derivatives XI and XII). Similarly, triester XVII gave by condensation with urea or thiourea the analogous 5-substituted derivatives of barbituric acid X, and thiobarbituric acid IX, respectively. The structures of selected compounds of this group (IV, V, IX-XI and XIII) were determined by spectral methods. Of interest, from the pharmacological point of view, has proved compound IV, which exhibited a significant antineoplastic effect on some experimental tumours in mice and rats, and enhanced the action of some current cytostatics.

Some 2-substituted derivatives of 5-(2-amino-6-hydroxy-4-oxo-3,4-dihydro-5-pyrimidinyl)pentanoic acid

1981 ◽  
Vol 46 (6) ◽  
pp. 1397-1404 ◽  
Author(s):  
Rudolf Kotva ◽  
Jiří Křepelka ◽  
Antonín Černý ◽  
Vojtěch Pujman ◽  
Miroslav Semonský
Keyword(s):  
Point Of View ◽  
Pentanoic Acid ◽  
Antineoplastic Effect ◽  
Derivatives Of

On condensation of 6-substituted trialkyl esters of 2-carboxy-1,7-heptanedioic acids XIII-XXIII with guanidineand subsequent saponification 2-substituted 5-(2-amino-6-hydroxy-4-oxo-3,4-dihydro-5-pyrimidinyl)pentanoic acids II-XII were prepared. From the pharmacological point of view some of the substances prepared had a potentiating effect on the antileukemia effect of 5-fluorouracil in mice and the antineoplastic effect manifested by a diminution of the tumours in animals with experimental tumours.

2-Substituted derivatives of 5-(4-oxo-3,4-dihydro-5-pyrimidinyl)pentanoic acid

1982 ◽  
Vol 47 (9) ◽  
pp. 2525-2529 ◽  
Author(s):  
Rudolf Kotva ◽  
Jiří Křepelka ◽  
Jaroslav Vachek
Keyword(s):  
Pentanoic Acid ◽  
Antineoplastic Effect ◽  
Derivatives Of

Condensation of trialkyl esters of 6-substituted 2-carboxy-1,7-heptanedioic acids XII-XVII with urea or thiourea and subsequent saponification gave 2-substituted 5-(2,6-dihydroxy-4-oxo-3,4-dihydro-5-pyrimidinyl)pentanoic acids II-VI or 5-(2-mercapto-6-hydroxy-4-oxo-3,4-dihydro-6-pyrimidinyl)pentanoic acids VII-XI, respectively. Compounds II, VII and X had a weak antineoplastic effect in animals with experimental transplantable tumours.

Convergence Analysis of the Spectral Methods for Weakly Singular Volterra Integro-Differential Equations with Smooth Solutions

2012 ◽  
Vol 4 (1) ◽  
pp. 1-20 ◽  
Author(s):  
Yunxia Wei ◽  
Yanping Chen
Keyword(s):  
Differential Equations ◽  
Spectral Methods ◽  
Approximate Solutions ◽  
Smooth Solutions ◽  
Weakly Singular Kernel ◽  
Numerical Examples ◽  
Weakly Singular ◽  
Rigorous Error ◽  
Derivatives Of ◽  
Theoretical Results

AbstractThe theory of a class of spectral methods is extended to Volterra integro-differential equations which contain a weakly singular kernel (t - s)->* with 0< μ <1. In this work, we consider the case when the underlying solutions of weakly singular Volterra integro-differential equations are sufficiently smooth. We provide a rigorous error analysis for the spectral methods, which shows that both the errors of approximate solutions and the errors of approximate derivatives of the solutions decay exponentially inL°°-norm and weightedL2-norm. The numerical examples are given to illustrate the theoretical results.

scholarly journals Synthesis of peroxy oligomers using 1,2-epoxy-3-tert-butyl peroxypropane

2008 ◽  
Vol 2 (4) ◽  
pp. 271-279
Author(s):  
Michael Bratychak ◽  
◽  
Mikhailo Bratychak ◽  
Olena Astakhova ◽  
Olena Shyshchak ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Bisphenol A ◽  
Spectral Methods ◽  
Phenol Formaldehyde ◽  
Tert Butyl ◽  
Derivatives Of

The possibility of peroxy oligomer synthesis has been studied by three methods: telomerization of diepoxy derivatives of ethylene glycol or Bisphenol A using 1,2-epoxy-3-tert-butyl peroxypropane as telogen, modification of phenol-formaldehyde resins by 1,2-epoxy-3-tert-butyl peroxypropane and polycondensation of phenol containing –O–O– bonds with formaldehyde. The peroxy oligomers obtaining conditions have been established and 7 new oligomers with peroxy groups have been synthesized. The structures of synthesized oligomers have been verified by chemical and spectral methods.

scholarly journals Synthesis of Some New 1,2,4-Triazoles Derived from 2-Mercaptobenzimidazole

2009 ◽  
Vol 6 (1) ◽  
pp. 200-208
Author(s):  
Baghdad Science Journal
Keyword(s):  
Physical Properties ◽  
Hydrazine Hydrate ◽  
Schiff Bases ◽  
Alkaline Medium ◽  
Spectral Methods ◽  
Ring Closure ◽  
Triazole Derivatives ◽  
Specific Reactions ◽  
Derivatives Of

New 1,2,4-triazole derivatives of 2-mercaptobenzimidazole (MB) are reported. Ethyl (benzimidazole-2-yl thio) acetate (1) has been prepared by condensing 2-mercaptobenzimidazole with ethylchloroacetate. The ester (1) on reacting with hydrazine hydrate gave the corresponding acetohydrazide(2)which was reacted separately with phenylisocyanate and phenylisothiocyanate, followed by ring closure in an alkaline medium giving 3-[(benzimidazole-2-yl thio) methyl]-4-phenyl-1,2,4-triazole-5-ol and 3-[(benzimidazole-2-yl thio) methyl]-4-phenyl-1,2,4-triazole-5-thiol respectively (6,7). Reaction of acetohydrazide (2) with CS2 and ethanol/KOH, gave dithiocarbazate salt (8). Cyclization of (8) with hydrazine hydrate gave 3-[(benzimidazole-2-yl thio) methyl]-4-amino-1,2,4-triazole-5-thiol (9). Furthermore, new Schiff bases (3a-e) were prepared through the reaction of the acetohydrazide (2) with aromatic aldehydres. The prepared compounds were identified by spectral methods FTIR, UV. Measurements of some physical properties and some specific reactions, were carried out.

scholarly journals Development of a mathematical model for alkylation of m-cresol with α-methylstyrene using anhydrous aluminium chloride

2019 ◽  
Vol 54 (3) ◽  
pp. 195-202
Author(s):  
S Sultana ◽  
ASMS Arefin ◽  
M Shahruzzaman
Keyword(s):  
Mathematical Model ◽  
Polymeric Materials ◽  
Aluminium Chloride ◽  
Molar Ratio ◽  
High Yield ◽  
Practical Utilization ◽  
Anhydrous Aluminium Chloride ◽  
Chloride Catalyst ◽  
Ft Ir ◽  
Burman Design

Alkylaromatic compounds such as alkylphenols are the most wide spread and efficient material due to its broad practical utilization in different arenas including antioxidants, stabilizers for fuels, lubricating oils, polymeric materials and so on. In this work, (2-phenylpropan-2-yl) m-cresol with high yield was prepared from the reaction between m-cresol and _-methylstyrene in the presence of anhydrous aluminium chloride catalyst. Plackett-Burman design was applied for screening significant variables, such as, temperature, molar ratio of m-cresol to _-methylstyrene, time of reaction and amount of catalyst etc. to determine an optimum condition for the production of (2-phenylpropan-2-yl) m-cresol. Moreover, a 23 Yates pattern factorial design was used to develop a mathematical model to predict the yield of alkylation of m-cresol with _-methylstyrene. Analyses of the results revealed that temperature, molar ratio and amount of catalyst were the main effective variables. The products were characterized by FT-IR, UV-visible and 1H NMR spectroscopy. The adequacy of the suggested model was checked up. The experimental yields exhibited good agreement with the predicted yields designed by the mathematical model. Hence, (2-phenylpropan-2-yl) m-cresol has the potential to be used as an industrially important compound in various applications. Bangladesh J. Sci. Ind. Res.54(3), 195-202, 2019

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