[1-β-Mercaptopropionic acid, 4-asparagine,8-D-arginine]vasopressin, an analogue with a high and very pure antidiuretic activity

1977 ◽  
Vol 42 (12) ◽  
pp. 3654-3657 ◽  
Author(s):  
M. Zaoral ◽  
I. Bláha
Keyword(s):  
Arginine Vasopressin ◽  
Mercaptopropionic Acid ◽  
Antidiuretic Activity

Synthesis of [1-β-mercaptopropionic acid, 8-D-arginine]vasopressin (DDAVP) in solid phase. Simple optimalization

1979 ◽  
Vol 44 (4) ◽  
pp. 1173-1178 ◽  
Author(s):  
Viktor Krchňák ◽  
Milan Zaoral
Keyword(s):  
Arginine Vasopressin ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Experimental Conditions ◽  
Phase Synthesis ◽  
Mercaptopropionic Acid ◽  
Better Than

A series of solid-phase syntheses of the protected precursor II of DDAVP was carried out. Experimental conditions were developed under which practically pure II can reproducibly be obtained in yields better than 60%. The protected precursors of DDAVP obtained by liquid- and solid-phase synthesis and DDAVP samples obtained from these precursors were undistinguishable by conventional analytical or pharmacological assays.

ChemInform Abstract: Potent Antagonists of Vasopressin Antidiuretic Activity That Lack the β,β-Cyclopentamethylene-β-mercaptopropionic Acid Substitution at Position 1.

ChemInform ◽  
1987 ◽  
Vol 18 (18) ◽  
Author(s):  
N. C. F. YIM ◽  
M. L. MOORE ◽  
W. F. HUFFMAN ◽  
H. G. BRYAN ◽  
H.-L. CHANG ◽  
...  
Keyword(s):  
Mercaptopropionic Acid ◽  
Antidiuretic Activity

scholarly journals A DENSIMETRIC METHOD FOR ASSAY OF SMALL AMOUNTS OF ANTIDIURETIC HORMONE

1957 ◽  
Vol 105 (6) ◽  
pp. 585-590 ◽  
Author(s):  
Niels A. Thorn
Keyword(s):  
Antidiuretic Hormone ◽  
Arginine Vasopressin ◽  
Urinary Flow ◽  
Flow Rates ◽  
Antidiuretic Activity ◽  
Reproducible Method

A sensitive and reproducible method for assay of antidiuretic activity, described in this paper, yielded accurate measurements in the range 60 to 540 micropressor units of pitressin, corresponding to about 15 to 130 micropressor units of arginine-vasopressin. The method differs from previous techniques mainly in using urine density, rather than urinary flow rates, as the index of response.

IDENTIFICATION OF THE ANTIDIURETIC SUBSTANCE IN HUMAN URINE

1960 ◽  
Vol XXXV (IV) ◽  
pp. 568-574 ◽  
Author(s):  
Frederick S. Mayer
Keyword(s):  
Arginine Vasopressin ◽  
Human Subjects ◽  
Water System ◽  
Assay Method ◽  
List Type ◽  
Posterior Lobe ◽  
Dose Response Relationship ◽  
Duration Of Action ◽  
Antidiuretic Activity ◽  
Acetic Acid Water

ABSTRACT 1. The urine of human subjects voided after smoking has been extracted by a method employing adsorption on zinc ferrocyanide and the extracts tested for the antidiuretic activity of arginine vasopressin by the intravenous assay method of Jeffers et al. with modifications by Dicker. 2. Smokers' urine extracts had an antidiuretic activity of approximately 100 mU of arginine vasopressin per litre of urine. 3. The pattern of the antidiuretic response of the urine extracts with regards to the dose-response relationship and duration of action was identical with that elicited by the U. S. P. reference standard of arginine vasopressin. 4. Upon paper chromatography by the descending method with the butanol-acetic acid-water system, the urine extract showed an Rf value identical to that of another sample of arginine vasopressin. 5. The antidiuretic substance excreted in human smokers' urine is arginine vasopressin, the hormone from the posterior lobe of the pituitary gland.

[1-β-Mercaptopropionic acid, 8-α-amino-β-guanidinopropionic acid]vasopressin and [1-β-mercaptopropionic acid, 8-D-α-amino-β-guanidinopropionic acid]vasopressin; Analogs showing a high and specific antidiuretic effect

1979 ◽  
Vol 44 (8) ◽  
pp. 2447-2450 ◽  
Author(s):  
Milan Zaoral ◽  
Viktor Krchňák ◽  
František Brtník ◽  
Alena Machová ◽  
Jana Škopková
Keyword(s):  
Hydrogen Fluoride ◽  
Arginine Vasopressin ◽  
Liquid Hydrogen ◽  
Protecting Groups ◽  
Pressor Effect ◽  
Mercaptopropionic Acid ◽  
Antidiuretic Effect

β-Benzylthiopropionyl-tyrosyl-phenylalanyl-glutaminyl-asparaginyl-S-benzylcysteine azide was condensed with prolyl-α-amino-nitroguanidinopropionyl-glycine amides (L2; D2) to β-benzylthiopropionyl-tyrosyl-phenylalanyl-glutaminyl-asparaginyl-S-benzylcysteinyl-prolyl-α-amino-β-nitroguanidinopropionyl-glycine amides (L8; D8) which after removal of the protecting groups in liquid hydrogen fluoride, closure of the disulfide ring, desalting, and electrophoretic purification afforded [1-β-mercaptopropionic acid, 8-α-amino-β-guanidinopropionic acid]vasopressin (I) and [1-β-mercaptopropionic acid, 8-D-α-amino-β-guanidinopropionic acid]vasopressin (II). The antidiuretic effect of I (II) is about 10% of the effect of [1-β-mercaptopropionic acid, 8-D-arginine]vasopressin (DDAVP) (87 ± 8% DDAVP), the pressor effect is 49.5 I.U./mg (2.7 I.U./mg).

Structural Changes in the Arginine Vasopressin Molecule that Enhance Antidiuretic Activity and Specificity1

Endocrinology ◽  
1974 ◽  
Vol 94 (4) ◽  
pp. 1106-1115 ◽  
Author(s):  
W. H. SAWYER ◽  
M. ACOSTA ◽  
L. BALASPIRI ◽  
J. JUDD ◽  
M. MANNING
Keyword(s):  
Arginine Vasopressin ◽  
Structural Changes ◽  
Antidiuretic Activity
Sign in / Sign up

Export Citation Format

Share Document