scholarly journals Development of experimental respiratory infections in neutropenic rats with either penicillin-resistant Streptococcus pneumoniae or beta-lactamase-producing Haemophilus influenzae.

1994 ◽  
Vol 38 (3) ◽  
pp. 608-610 ◽  
Author(s):  
G M Smith ◽  
K H Abbott
Keyword(s):  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Respiratory Infections ◽  
Beta Lactamase

scholarly journals Natural Development of Antibodies against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis Protein Antigens during the First 13 Years of Life

2016 ◽  
Vol 23 (11) ◽  
pp. 878-883 ◽  
Author(s):  
Igor C. Borges ◽  
Dafne C. Andrade ◽  
Maria Regina A. Cardoso ◽  
Jorma Toppari ◽  
Mari Vähä-Mäkilä ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Antibody Production ◽  
Moraxella Catarrhalis ◽  
Respiratory Infections ◽  
Protein Antigens ◽  
Serum Samples ◽  
Content Type ◽  
Natural Development ◽  
Antibody Levels

ABSTRACTConserved protein antigens have been investigated as vaccine candidates against respiratory pathogens. We evaluated the natural development of antibodies againstStreptococcus pneumoniae,Haemophilus influenzae, andMoraxella catarrhalisproteins during childhood. Serum samples were collected from 50 healthy children from their first months to age 13 years (median sampling interval, 6 months). We also analyzed serum samples from 24 adults. Serum IgG antibodies against eight pneumococcal proteins (Ply, CbpA, PspA 1 and 2, PcpA, PhtD, StkP-C, and PcsB-N), threeH. influenzaeproteins, and fiveM. catarrhalisproteins were measured using a multiplexed bead-based immunoassay. Antibody levels were analyzed using multilevel mixed-effects regression and Spearman's correlation. Antibody levels against pneumococcal proteins peaked at 3 to 5 years of age and then reached a plateau. Antibody levels againstH. influenzaeproteins peaked during the second year and then stabilized. Antibody levels againstM. catarrhalisproteins peaked during the first year and then slowly decreased. Peak antibody levels during childhood were higher than those of adults. Correlations among pneumococcal antibody levels were highest among anti-CbpA, anti-PcpA, and anti-PhtD antibodies (r= 0.71 to 0.75;P< 0.001). The children presented 854 symptomatic respiratory infections on 586 occasions. Symptomatic respiratory infections did not improve prediction of antibody levels in the regression model. The maturation of immune responses against the investigated pneumococcal proteins shares similarities, especially among CbpA, PcpA, and PhtD. Antibody production againstH. influenzaeandM. catarrhalisproteins starts early in life and reaches peak levels earlier than antibody production against the pneumococcal proteins. Basal antibody levels are not related to the occurrence of symptomatic respiratory infections.

Occurrence of blaTEM and blaROB in Haemophilus species Causing Respiratory Tract Infections

2020 ◽  
Vol 20 (3) ◽  
pp. 385-388
Author(s):  
Prerna Khurana ◽  
Suchitra Shenoy
Keyword(s):  
Respiratory Tract ◽  
Haemophilus Influenzae ◽  
Antibiotic Susceptibility ◽  
Respiratory Infections ◽  
Care Center ◽  
Tertiary Care ◽  
Respiratory Pathogen ◽  
Beta Lactamase ◽  
Beta Lactam ◽  
Tract Infections

Background: Emergence of resistance to some antibiotics in Haemophilus influenzae, a respiratory pathogen is a cause of concern. The aim is to study the antibiotic susceptibility pattern of Haemophilus isolates from respiratory infections with reference to beta-lactam resistance. Methods: This is a laboratory based prospective study done in the department of microbiology in a tertiary care center after institutional ethics committee clearance. Haemophilus influenzae isolates from respiratory tract specimens over a period of one year were subjected to antibiotic susceptibility tests. Beta-lactamase production was detected by nitrocefin disc. hpd gene, blaTEM and blaROB genes were detected by PCR. The data was analysed using SPSS 11.5 version. Results: Of the 162 isolates, 89.5% were from sputum specimens. Ampicillin resistance was seen in 5 (3.09%) isolates. The ampicillin resistant strains were positive for beta-lactamase enzyme and blaTEM gene. BLNAR and isolates with blaROB gene were not found. Conclusion: In case of Haemophilus influenzae respiratory tract infection empirical treatment with amoxicillin clavulanate or third generation cephalosporin may be the drugs of choice in our geographic area.

Epidemiología de la meningitis producida por Haemophilus influenzae tipo b, Neisseria meningitidis y Streptococcus pneumoniae en niños de la Comunidad Valenciana, España

1998 ◽  
Vol 26 (149) ◽  
pp. 34 ◽  
Author(s):  
Mª Amparo Morant Gimeno ◽  
J. Díez Domingo ◽  
C. Gimeno ◽  
N. de la Muela ◽  
I. Pereiró ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Neisseria Meningitidis
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