In vitro Activity of a New Broad-Spectrum, Beta-Lactamase-Stable Oral Cephalosporin, Cefixime, in Comparison with Other Drugs, against Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis and Streptococcus pneumoniae

Chemotherapy ◽  
1992 ◽  
Vol 38 (1) ◽  
pp. 36-45 ◽  
Author(s):  
S. Stefani ◽  
M.B. Pellegrino ◽  
G. D’;Amico ◽  
A. Privitera ◽  
O. Privitera ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Broad Spectrum ◽  
Moraxella Catarrhalis ◽  
Vitro Activity ◽  
Beta Lactamase ◽  
In Vitro Activity ◽  
Oral Cephalosporin ◽  
Haemophilus Parainfluenzae

scholarly journals In vitro activity of BAY 12-8039, a novel 8-methoxyquinolone, compared to activities of six fluoroquinolones against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.

1997 ◽  
Vol 41 (7) ◽  
pp. 1594-1597 ◽  
Author(s):  
A B Brueggemann ◽  
K C Kugler ◽  
G V Doern
Keyword(s):  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Moraxella Catarrhalis ◽  
Ambient Air ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Broth Microdilution ◽  
Agar Dilution ◽  
Resistant Strains

The in vitro activity of a novel 8-methoxyquinolone, BAY 12-8039, against recent clinical isolates of Streptococcus pneumoniae (n = 404), Haemophilus influenzae (n = 330), and Moraxella catarrhalis (n = 250) was evaluated. Activity was compared to those of six other fluoroquinolones: ciprofloxacin, clinafloxacin, levofloxacin, ofloxacin, sparfloxacin and trovafloxacin. BAY 12-8039 and clinafloxacin had the highest levels of activity against S. pneumoniae, both with a MIC at which 90% of the isolates were inhibited (MIC90) of 0.06 microg/ml. Trovafloxacin and sparfloxacin were the next most active agents versus S. pneumoniae (MIC90s = 0.12 microg/ml). No differences in activity against penicillin-susceptible, -intermediate, or -resistant strains of S. pneumoniae were noted for any of the fluoroquinolones tested. MIC90s for the seven fluoroquinolones ranged from 0.008 to 0.06 microg/ml versus H. influenzae and from 0.008 to 0.12 microg/ml for M. catarrhalis. The MICs for two strains of S. pneumoniae and one strain of H. influenzae were noted to be higher than those for the general population of organisms for all of the fluoroquinolones tested. Finally, the activity of BAY 12-8039 versus S. pneumoniae was found to be diminished when MIC determinations were performed with incubation of agar dilution plates or broth microdilution trays in 5 to 7% CO2 versus ambient air.

scholarly journals In Vitro Activity of ABT-773, a New Ketolide, against Recent Clinical Isolates of Streptococcus pneumoniae, Haemophilus influenzae, andMoraxella catarrhalis

2000 ◽  
Vol 44 (2) ◽  
pp. 447-449 ◽  
Author(s):  
Angela B. Brueggemann ◽  
Gary V. Doern ◽  
Holly K. Huynh ◽  
Elizabeth M. Wingert ◽  
Paul R. Rhomberg
Keyword(s):  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Moraxella Catarrhalis ◽  
Vitro Activity ◽  
Clinical Isolates ◽  
In Vitro Activity

ABSTRACT The in vitro activity of ABT-773 was evaluated againstStreptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis isolates. ABT-773 was the most active antimicrobial tested against S. pneumoniae. ABT-773 and azithromycin were equivalent in activity against H. influenzae and M. catarrhalis and more active than either clarithromycin or erythromycin.

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