scholarly journals Randomized Controlled Trial of Fosmidomycin-Clindamycin versus Sulfadoxine-Pyrimethamine in the Treatment of Plasmodium falciparum Malaria

2007 ◽  
Vol 51 (5) ◽  
pp. 1869-1871 ◽  
Author(s):  
Sunny Oyakhirome ◽  
Saadou Issifou ◽  
Peter Pongratz ◽  
Fortune Barondi ◽  
Michael Ramharter ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Plasmodium Falciparum ◽  
Oral Dose ◽  
Randomized Trial ◽  
Single Oral Dose ◽  
Uncomplicated Malaria ◽  
Controlled Trial ◽  
Plasmodium Falciparum Malaria ◽  
Randomized Controlled ◽  
High Degree

ABSTRACT Fosmidomycin-clindamycin therapy given every 12 h for 3 days was compared with a standard single oral dose of sulfadoxine-pyrimethamine. The two treatments showed comparably good tolerabilities and had an identical high degree of efficacy of 94% in a randomized trial carried out with 105 Gabonese children aged 3 to 14 years with uncomplicated malaria. These antimalarials merit further clinical exploration.

Azithromycin versus Amoxicillin and Malarial Parasitemia among Children with Uncomplicated Severe Acute Malnutrition: A Randomized Controlled Trial

2021 ◽  
Author(s):  
Ali Sié ◽  
Clarisse Dah ◽  
Millogo Ourohiré ◽  
Moussa Ouédraogo ◽  
Valentin Boudo ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Severe Acute Malnutrition ◽  
Controlled Trial ◽  
Additional Benefit ◽  
Acute Malnutrition ◽  
Significant Evidence ◽  
Randomized Controlled

Antibiotics are recommended by the WHO as part of the management of uncomplicated severe acute malnutrition in children. We evaluated whether azithromycin, an antibiotic with antimalarial properties, improved malarial parasitemia outcomes in children with severe acute malnutrition compared with amoxicillin, an antibiotic commonly used for severe acute malnutrition that does not have antimalarial properties. Total of 301 children were randomized (1:1) to a single oral dose of azithromycin or a 7-day course of amoxicillin and followed for 8 weeks. We found no significant evidence that children receiving azithromycin had improved parasitemia outcomes relative to amoxicillin. Although azithromycin may have advantages over amoxicillin in terms of dosing and administration for uncomplicated severe acute malnutrition, it may not yield additional benefit for malaria outcomes.

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