scholarly journals Effectiveness of Co-trimoxazole to Prevent Plasmodium falciparum Malaria in HIV-Positive Pregnant Women in Sub-Saharan Africa: An Open-Label, Randomized Controlled Trial

2013 ◽  
Vol 58 (5) ◽  
pp. 651-659 ◽  
Author(s):  
E. Klement ◽  
P. Pitche ◽  
E. Kendjo ◽  
A. Singo ◽  
S. D'Almeida ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Plasmodium Falciparum ◽  
Pregnant Women ◽  
Controlled Trial ◽  
Plasmodium Falciparum Malaria ◽  
Sub Saharan Africa ◽  
Hiv Positive ◽  
Open Label ◽  
Randomized Controlled ◽  
Sub Saharan

Effect of Enhanced Adherence Package on Early ART Uptake Among HIV-Positive Pregnant Women in Zambia: An Individual Randomized Controlled Trial

2020 ◽  
Author(s):  
Mwangelwa Mubiana-Mbewe ◽  
Samuel Bosomprah ◽  
Jillian L. Kadota ◽  
Aybüke Koyuncu ◽  
Thankian Kusanathan ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Pregnant Women ◽  
Controlled Trial ◽  
Hiv Positive ◽  
Randomized Controlled

scholarly journals Randomized Controlled Trial of Fosmidomycin-Clindamycin versus Sulfadoxine-Pyrimethamine in the Treatment of Plasmodium falciparum Malaria

2007 ◽  
Vol 51 (5) ◽  
pp. 1869-1871 ◽  
Author(s):  
Sunny Oyakhirome ◽  
Saadou Issifou ◽  
Peter Pongratz ◽  
Fortune Barondi ◽  
Michael Ramharter ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Plasmodium Falciparum ◽  
Oral Dose ◽  
Randomized Trial ◽  
Single Oral Dose ◽  
Uncomplicated Malaria ◽  
Controlled Trial ◽  
Plasmodium Falciparum Malaria ◽  
Randomized Controlled ◽  
High Degree

ABSTRACT Fosmidomycin-clindamycin therapy given every 12 h for 3 days was compared with a standard single oral dose of sulfadoxine-pyrimethamine. The two treatments showed comparably good tolerabilities and had an identical high degree of efficacy of 94% in a randomized trial carried out with 105 Gabonese children aged 3 to 14 years with uncomplicated malaria. These antimalarials merit further clinical exploration.

scholarly journals Effectiveness of preoperative bath using Chloroxylenol antiseptic soap on the incidence of post emergency Cesarean section surgical site infection at Mbarara Regional Referral hospital, Uganda: a Randomized Controlled trial

2020 ◽  
Author(s):  
Henry Lukabwe ◽  
Rogers Kajabwangu ◽  
Dale Mugisha ◽  
Horace Kizito ◽  
Baraka Munyanderu ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Cesarean Section ◽  
Controlled Trial ◽  
Surgical Site Infections ◽  
Referral Hospital ◽  
Sub Saharan Africa ◽  
Regional Referral Hospital ◽  
Randomized Controlled ◽  
Emergency Cesarean ◽  
Sub Saharan

Abstract Introduction: Surgical Site Infections (SSIs) are infections that occur at or near the surgical incision within 30 days of the surgery. SSIs are the commonest form of hospital acquired infections in sub Saharan Africa with estimates between 15%-45%. Cesarean section (CS) is the single most important risk factor for postpartum infections, carrying a 5 to 20-fold increase in the risk of developing sepsis, with an even higher risk when the operation is an emergency. In sub Saharan Africa, the leading cause of maternal mortality is puerperal sepsis. There is a need for simple interventions that can reduce this burden of SSI in the limited resource settings. Therefore, the purpose of this study was to measure the effectiveness of chloroxylenol in reducing the incidence of post Cesarean section surgical site infections at Mbarara Regional Referral Hospital (MRRH).Methods: We conducted a single blinded randomized controlled trial at MRRH maternity ward in which women due for CS were randomized into either control or intervention arms. The intervention was a complete body bath with chloroxylenol antiseptic soap before the operation, while the control arm study participants received a standard pre-operative preparation procedures according to the existing ward protocol. All participants were followed up for 30 days and assessed using a standard SSI screening tool. Results: Ninety-six women were randomized, and 48 were assigned to either arm. The overall incidence of SSI was 30.21%. The incidence of SSI was significantly lower in the intervention compared to the control arm, at 6.25% in the intervention arm versus 54.17% in the control arm (p value<0.001). Chloroxylenol bath was protective of SSI with a 90% risk reduction for SSI (95% confidence interval of 67% – 97%). Conclusion: A preoperative bath with chloroxylenol for pregnant mothers is associated with a significantly lower risk of post Cesarean section surgical site infections. Health facilities with a high burden of post SSI should consider adding this simple and effective intervention to the existing infection prevention measures. Clinical Trials.gov registration (NCT03544710).

Short-term Effects of Calcium and Vitamin D Supplementation in Postmenopausal Hypertensive Patients in sub-Saharan Africa: A Double Blinded Randomized Controlled Trial

2021 ◽  
Vol 1 (3) ◽  
pp. 59-64
Author(s):  
Chris Nadège Nganou-Gnindjio ◽  
Vicky Jocelyne Ama Moor ◽  
Constant Anatole Pieme ◽  
Guy Sadeu Wafeu ◽  
Ingrid Ngandjeu Kamtchoum ◽  
...  
Keyword(s):  
Vitamin D ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
Sub Saharan Africa ◽  
Short Term ◽  
Hypertensive Patients ◽  
Randomized Controlled ◽  
Sub Saharan ◽  
Double Blinded
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