scholarly journals Measurement of Voriconazole Activity against Candida albicans, C. glabrata, and C. parapsilosis Isolates Using Time-Kill Methods Validated by High-Performance Liquid Chromatography

2007 ◽  
Vol 51 (8) ◽  
pp. 2985-2987 ◽  
Author(s):  
Yanjun Li ◽  
M. Hong Nguyen ◽  
Hartmut Derendorf ◽  
Shaoji Cheng ◽  
Cornelius J. Clancy
Keyword(s):  
High Performance Liquid Chromatography ◽  
Candida Albicans ◽  
Liquid Chromatography ◽  
High Performance ◽  
Candida Parapsilosis ◽  
Hplc Assay ◽  
Fungistatic Activity ◽  
Human Sera ◽  
Time Kill ◽  
Postantifungal Effect

ABSTRACT We developed a high-performance liquid chromatography (HPLC) assay to validate time-kill and postantifungal-effect (PAFE) experiments for voriconazole against Candida albicans, Candida glabrata, and Candida parapsilosis isolates. Voriconazole exerted prolonged fungistatic activity but no PAFE at concentrations achievable in human sera. HPLC confirmed that experiments were conducted at the desired steady-state voriconazole concentrations.

scholarly journals Characterizing the Effects of Caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata Isolates by Simultaneous Time-Kill and Postantifungal-Effect Experiments

2006 ◽  
Vol 50 (7) ◽  
pp. 2569-2572 ◽  
Author(s):  
Cornelius J. Clancy ◽  
Hong Huang ◽  
Shaoji Cheng ◽  
Hartmut Derendorf ◽  
M. Hong Nguyen
Keyword(s):  
Candida Albicans ◽  
Candida Glabrata ◽  
Candida Parapsilosis ◽  
Measured Time ◽  
Time Kill ◽  
Postantifungal Effect

ABSTRACT We measured time-kills and postantifungal effects (PAFEs) of caspofungin against Candida albicans, C. parapsilosis, and C. glabrata isolates. One-hour exposure to caspofungin during PAFE experiments accounted for the majority of killing during time-kill experiments. Regrowth of all isolates was inhibited for at least 24 h following drug washout.

High-Performance Liquid Chromatography (HPLC) Assay

2016 ◽  
Author(s):  
John Proudfoot ◽  
Olivier Nosjean ◽  
Jan Blanchard ◽  
John Wang ◽  
Dominique Besson ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Hplc Assay
Sign in / Sign up

Export Citation Format

Share Document