scholarly journals An evolutionarily conserved gene family encodes proton-selective ion channels

Science ◽  
2018 ◽  
Vol 359 (6379) ◽  
pp. 1047-1050 ◽  
Author(s):  
Yu-Hsiang Tu ◽  
Alexander J. Cooper ◽  
Bochuan Teng ◽  
Rui B. Chang ◽  
Daniel J. Artiga ◽  
...  
Keyword(s):  
Ion Channels ◽  
Gene Family ◽  
Evolutionarily Conserved ◽  
Conserved Gene

scholarly journals Evolutionarily conserved gene family important for fat storage

2007 ◽  
Vol 105 (1) ◽  
pp. 94-99 ◽  
Author(s):  
B. Kadereit ◽  
P. Kumar ◽  
W.-J. Wang ◽  
D. Miranda ◽  
E. L. Snapp ◽  
...  
Keyword(s):  
Gene Family ◽  
Fat Storage ◽  
Evolutionarily Conserved ◽  
Conserved Gene

scholarly journals Cloning and Characterization of peter pan, a NovelDrosophila Gene Required for Larval Growth

1999 ◽  
Vol 10 (6) ◽  
pp. 1733-1744 ◽  
Author(s):  
Jacques C. Migeon ◽  
Michele S. Garfinkel ◽  
Bruce A. Edgar
Keyword(s):  
Dna Replication ◽  
Gene Family ◽  
Larval Growth ◽  
P Element ◽  
Peter Pan ◽  
Evolutionarily Conserved ◽  
Imaginal Disks ◽  
Type Gene ◽  
Conserved Gene

We identified a new Drosophila gene, peter pan (ppan), in a screen for larval growth–defective mutants. ppan mutant larvae do not grow and show minimal DNA replication but can survive until well after their heterozygotic siblings have pupariated. We cloned theppan gene by P-element plasmid rescue.ppan belongs to a highly conserved gene family that includes Saccharomyces cerevisiae SSF1 and SSF2, as well as Schizosaccharomyces pombe,Arabidopsis, Caenorhabditis elegans, mouse, and human homologues. Deletion of both SSF1 and SSF2 in yeast is lethal, and depletion of the gene products causes cell division arrest. Mosaic analysis of ppan mutant clones inDrosophila imaginal disks and ovaries demonstrates that ppan is cell autonomous and required for normal mitotic growth but is not absolutely required for general biosynthesis or DNA replication. Overexpression of the wild-type gene causes cell death and disrupts the normal development of adult structures. The ppan gene family appears to have an essential and evolutionarily conserved role in cell growth.

scholarly journals Evolution, expression and functional analysis of cultivated allotetraploid cotton DIR genes

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhengwen Liu ◽  
Xingfen Wang ◽  
Zhengwen Sun ◽  
Yan Zhang ◽  
Chengsheng Meng ◽  
...  
Keyword(s):  
Gene Family ◽  
Stress Responses ◽  
Rapid Evolution ◽  
Gene Clusters ◽  
Vital Role ◽  
Fiber Development ◽  
Rna Seq ◽  
Evolutionarily Conserved ◽  
Cell Wall Development ◽  
Tandem Duplications

Abstract Background Dirigent (DIR) proteins mediate regioselectivity and stereoselectivity during lignan biosynthesis and are also involved in lignin, gossypol and pterocarpan biosynthesis. This gene family plays a vital role in enhancing stress resistance and in secondary cell-wall development, but systematical understanding is lacking in cotton. Results In this study, 107 GbDIRs and 107 GhDIRs were identified in Gossypium barbadense and Gossypium hirsutum, respectively. Most of these genes have a classical gene structure without intron and encode proteins containing a signal peptide. Phylogenetic analysis showed that cotton DIR genes were classified into four distinct subfamilies (a, b/d, e, and f). Of these groups, DIR-a and DIR-e were evolutionarily conserved, and segmental and tandem duplications contributed equally to their formation. In contrast, DIR-b/d mainly expanded by recent tandem duplications, accompanying with a number of gene clusters. With the rapid evolution, DIR-b/d-III was a Gossypium-specific clade involved in atropselective synthesis of gossypol. RNA-seq data highlighted GhDIRs in response to Verticillium dahliae infection and suggested that DIR gene family could confer Verticillium wilt resistance. We also identified candidate DIR genes related to fiber development in G. barbadense and G. hirsutum and revealed their differential expression. To further determine the involvement of DIR genes in fiber development, we overexpressed a fiber length-related gene GbDIR78 in Arabidopsis and validated its function in trichomes and hypocotyls. Conclusions These findings contribute novel insights towards the evolution of DIR gene family and provide valuable information for further understanding the roles of DIR genes in cotton fiber development as well as in stress responses.

scholarly journals Independent origins of the Golgi phosphoprotein 3 oncoprotein gene

2021 ◽  
Author(s):  
Juan C. Opazo ◽  
Michael W. Vandewege ◽  
Javier Gutierrez ◽  
Kattina Zavala ◽  
Luis Vargas-Chacoff ◽  
...  
Keyword(s):  
Gene Family ◽  
Transcript Abundance ◽  
Single Copy ◽  
Model Systems ◽  
Deep Roots ◽  
Starting Point ◽  
Amino Acid Divergence ◽  
Evolutionarily Conserved ◽  
History Of ◽  
Divergence Estimates

AbstractGolgi phosphoprotein 3 (GOLPH3) is considered the first oncoprotein of the Golgi apparatus. It was identified as an evolutionarily conserved protein upon its discovery about 20 years ago, but its function remains puzzling in normal and cancer cells. The GOLPH3 gene is part of a group of genes that also includes the GOLPH3L gene. Because cancer has deep roots in multicellular evolution, studying the evolution of the GOLPH3 gene family in non-model species represents an opportunity to identify new model systems that could help better understand the biology behind this group of genes. The main goal of this study is to explore the evolution of the GOLPH3 gene family in birds as a starting point to understand the evolutionary history of this oncoprotein. We identified a repertoire of three GOLPH3 genes in birds. We found duplicated copies of the GOLPH3 gene in all main groups of birds other than paleognaths, and a single copy of the GOLPH3L gene. We suggest there were at least three independent origins for GOLPH3 duplicates. Amino acid divergence estimates show that most of the variation is located in the N-terminal region of the protein. Our transcript abundance estimations show that one paralog is highly and ubiquitously expressed, and the others were variable. Our results are an example of the significance of understanding the evolution of the GOLPH3 gene family, especially for unraveling its structural and functional attributes.

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