THE INTERRELATIONSHIP OF VITAMIN A AND GLUCURONIC ACID IN MUCINE METABOLISM

Science ◽  
1937 ◽  
Vol 85 (2193) ◽  
pp. 44-45 ◽  
Author(s):  
I. A. Manville
Keyword(s):  
Vitamin A ◽  
Glucuronic Acid

scholarly journals All-trans-retinoyl β-glucuronide: new procedure for chemical synthesis and its metabolism in vitamin A-deficient rats

1996 ◽  
Vol 314 (1) ◽  
pp. 249-252 ◽  
Author(s):  
Bruno BECKER ◽  
Arun B. BARUA ◽  
James A. OLSON
Keyword(s):  
Retinoic Acid ◽  
Vitamin A ◽  
Chemical Synthesis ◽  
Glucuronic Acid ◽  
Major Metabolite ◽  
Triazole Derivative ◽  
Tetrabutylammonium Salt ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
High Yields

All-trans-retinoyl β-glucuronide (RAG) was chemically synthesized in high yields (up to 79%) by a new procedure involving the reaction of the tetrabutylammonium salt of glucuronic acid with all-trans-retinoic acid (RA) via the imidazole or triazole derivative. When RAG was fed orally to vitamin A-deficient rats, RA was identified as the major metabolite in the serum within hours of administration of RAG. Very little or no RAG was detected in the serum. Thus RAG, which was not appreciably hydrolysed to RA in vitamin A-sufficient rats [Barua and Olson (1987) Biochem J. 263, 403–409], was rapidly converted into RA in vitamin A-deficient rats.

Retinoyl Beta-Glucuronic Acid: A Major Metabolite of Vitamin A in Rat Bile

Science ◽  
1965 ◽  
Vol 148 (3666) ◽  
pp. 86-87 ◽  
Author(s):  
P. E. Dunagin ◽  
E. H. Meadows ◽  
J. A. Olson
Keyword(s):  
Vitamin A ◽  
Glucuronic Acid ◽  
Major Metabolite ◽  
Rat Bile

scholarly journals HEPATIC VITAMIN A IN THE RAT AS AFFECTED BY THE ADMINISTRATION OF DIBENZANTHRACENE

1942 ◽  
Vol 76 (2) ◽  
pp. 143-161 ◽  
Author(s):  
Jules C. Abels ◽  
Alice T. Gorham ◽  
Shirley L. Eberlin ◽  
Robert Halter ◽  
C. P. Rhoads
Keyword(s):  
Vitamin A ◽  
Serum Albumin ◽  
Hepatic Dysfunction ◽  
Glucuronic Acid ◽  
Total Fat ◽  
Hepatic Synthesis ◽  
Esterify Cholesterol

1. The decreased concentrations of vitamin A in the livers of rats given dibenzanthracene probably are due to a particular effect of the carcinogen on the ability of the liver to store the vitamin and not to the production of general hepatic dysfunction. 2. The administration of dibenzanthracene to normal rats does not (a) increase significantly their hepatic content of total fat nor decrease that of phospholipid; (b) impair the ability of their livers to fabricate serum albumin; (c) impair the capacity of their livers to esterify cholesterol or phenol; (d) interfere with the hepatic synthesis and conjugation of glucuronic acid; or (e) interfere with the hepatic storage of riboflavin. 3. The simultaneous ingestion of yeast by the dibenzanthracene-treated rats further depletes their hepatic stores of vitamin A. This depletion conceivably is due to the fact that yeast alone also might deplete the liver of its vitamin A and thus a summation of two similar effects is attained. 4. The results suggest a competition between vitamin A and dibenzanthracene for some substance, possibly a protein, to which vitamin A may be bound in the liver.

The Morphology of Vacuolated Cells in the Liver Following Administration of Vitamin A.

1973 ◽  
Vol 31 ◽  
pp. 408-409
Author(s):  
Odell T. Minick ◽  
Hidejiro Yokoo ◽  
Fawzia Batti
Keyword(s):  
Electron Microscopy ◽  
Body Weight ◽  
Vitamin A ◽  
Light And Electron Microscopy ◽  
Liver Cells ◽  
Prominent Feature ◽  
Vascular Space ◽  
Vacuolated Cell ◽  
Vacuolated Cells ◽  
Vacuolated Cytoplasm

Vacuolated cells in the liver of young rats were studied by light and electron microscopy following the administration of vitamin A (200 units per gram of body weight). Their characteristics were compared with similar cells found in untreated animals.In rats given vitamin A, cells with vacuolated cytoplasm were a prominent feature. These cells were found mostly in a perisinusoidal location, although some appeared to be in between liver cells (Fig. 1). Electron microscopy confirmed their location in Disse's space adjacent to the sinusoid and in recesses between liver cells. Some appeared to be bordering the lumen of the sinusoid, but careful observation usually revealed a tenuous endothelial process separating the vacuolated cell from the vascular space. In appropriate sections, fenestrations in the thin endothelial processes were noted (Fig. 2, arrow).

The Effect of Vitamin A on the Intermittent Nitrogen Dioxide Gas Exposure in Hamsters

1976 ◽  
Vol 34 ◽  
pp. 176-177
Author(s):  
J.C.S. Kim ◽  
M.G. Jourden ◽  
E.S. Carlisle
Keyword(s):  
Electron Microscopy ◽  
Vitamin A ◽  
Nitrogen Dioxide ◽  
Chronic Exposure ◽  
Light And Electron Microscopy ◽  
Specific Effect ◽  
Deficient Diet ◽  
Intermittent Exposure ◽  
Hypovitaminosis A ◽  
Gas Exposure

Chronic exposure to nitrogen dioxide in rodents has shown that injury reaches a maximum after 24 hours, and a reparative adaptive phase follows (1). Damage occurring in the terminal bronchioles and proximal portions of the alveolar ducts in rats has been extensively studied by both light and electron microscopy (1).The present study was undertaken to compare the response of lung tissue to intermittent exposure to 10 ppm of nitrogen dioxide gas for 4 hours per week, while the hamsters were on a vitamin A deficient diet. Ultrastructural observations made from lung tissues obtained from non-gas exposed, hypovitaminosis A animals and gas exposed animals fed a regular commercially prepared diet have been compared to elucidate the specific effect of vitamin A on nitrogen dioxide gas exposure. The interaction occurring between vitamin A and nitrogen dioxide gas has not previously been investigated.

An Evaluation of the Isotopic Iodotriolein Method; its Correlation With Vitamin a Absorption

1958 ◽  
Vol 35 (4) ◽  
pp. 381-386 ◽  
Author(s):  
Sidney M. Fierst ◽  
Saul M. Feldman ◽  
Nathan Solomon ◽  
Abraham Lanosam
Keyword(s):  
Vitamin A
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