Partial amino acid sequence of the precursor of immunoglobulin light chain programmed by messenger RNA in vitro

Science ◽  
1975 ◽  
Vol 188 (4184) ◽  
pp. 160-162 ◽  
Author(s):  
I Schechter
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Light Chain ◽  
Messenger Rna ◽  
Immunoglobulin Light Chain ◽  
Partial Amino Acid Sequence

Partial amino acid sequence of a rabbit immunoglobulin light chain of allotype b5

Biochemistry ◽  
1983 ◽  
Vol 22 (4) ◽  
pp. 993-998 ◽  
Author(s):  
Hammadi Ayadi ◽  
Sophie Dutka ◽  
Pierre Paroutaud ◽  
A. Donny Strosberg
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Light Chain ◽  
Immunoglobulin Light Chain ◽  
Partial Amino Acid Sequence ◽  
Rabbit Immunoglobulin

scholarly journals Rat liver preproalbumin: in vitro synthesis and partial amino acid sequence.

1977 ◽  
Vol 74 (4) ◽  
pp. 1358-1362 ◽  
Author(s):  
A. W. Strauss ◽  
A. M. Donohue ◽  
C. D. Bennett ◽  
J. A. Rodkey ◽  
A. W. Alberts
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Rat Liver ◽  
Partial Amino Acid Sequence ◽  
In Vitro Synthesis

scholarly journals The Amino Acid Sequence of the Glycosylated Amyloid Immunoglobulin Light Chain Protein AL MS

1997 ◽  
Vol 45 (5) ◽  
pp. 551-556 ◽  
Author(s):  
L. A. OMTVEDT ◽  
G. HUSBY ◽  
G. G. CORNWELL III ◽  
R. A. KYLE ◽  
K. SLETTEN
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Light Chain ◽  
Immunoglobulin Light Chain

scholarly journals An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice.

1990 ◽  
Vol 171 (6) ◽  
pp. 1919-1930 ◽  
Author(s):  
A Puccetti ◽  
T Koizumi ◽  
P Migliorini ◽  
J André-Schwartz ◽  
K J Barrett ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Light Chain ◽  
Hypervariable Region ◽  
Immunoglobulin Light Chain ◽  
Antigenic Region

Autoantibodies against the 70-kD U1 RNP nucleoprotein autoantigen and DNA were elicited in normal BALB/c mice with a purified Ig light chain. This light chain, derived from a lupus-prone MRL-lpr/lpr mouse, has two distinctive properties: it contains an idiotypic marker recognized by a monoclonal MRL-lpr/lpr anti-snRNP autoantibody, and the amino acid sequence of its third hypervariable region (CDR3) is homologous to a sequence in an antigenic region of the 70-kD U1 RNP polypeptide. The results demonstrate that an Ig idiotype that mimics an autoantigen can induce autoimmunization.

scholarly journals A λ Bence-Jones protein in guinea pigs

1975 ◽  
Vol 151 (3) ◽  
pp. 751-753 ◽  
Author(s):  
F K Stevenson ◽  
L E Mole ◽  
C M Raymont ◽  
G T Stevenson
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Light Chain ◽  
Guinea Pigs ◽  
Lymphocytic Leukaemia ◽  
Immunoglobulin Light Chain ◽  
Bence Jones Protein ◽  
Close Analogy ◽  
Leukaemic Cells ◽  
V Region

1. The L2C lymphocytic leukaemia in strain-2 guinea pigs is accompanied by a protein in the urine resembling a homogenous immunoglobulin light chain. 2. The amino acid sequence over the first 20 residues demonstrates a close analogy with a human λ chain of V region subgroup IV. 3. The protein is apparently synthesized by the leukaemic cells and thus represents a monoclonal light chain, i.e. a Bence-Jones protein.

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