Partial amino acid sequence of a rabbit immunoglobulin light chain of allotype b5

Biochemistry ◽  
1983 ◽  
Vol 22 (4) ◽  
pp. 993-998 ◽  
Author(s):  
Hammadi Ayadi ◽  
Sophie Dutka ◽  
Pierre Paroutaud ◽  
A. Donny Strosberg
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Light Chain ◽  
Immunoglobulin Light Chain ◽  
Partial Amino Acid Sequence ◽  
Rabbit Immunoglobulin

scholarly journals The Amino Acid Sequence of the Glycosylated Amyloid Immunoglobulin Light Chain Protein AL MS

1997 ◽  
Vol 45 (5) ◽  
pp. 551-556 ◽  
Author(s):  
L. A. OMTVEDT ◽  
G. HUSBY ◽  
G. G. CORNWELL III ◽  
R. A. KYLE ◽  
K. SLETTEN
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Light Chain ◽  
Immunoglobulin Light Chain

scholarly journals An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice.

1990 ◽  
Vol 171 (6) ◽  
pp. 1919-1930 ◽  
Author(s):  
A Puccetti ◽  
T Koizumi ◽  
P Migliorini ◽  
J André-Schwartz ◽  
K J Barrett ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Light Chain ◽  
Hypervariable Region ◽  
Immunoglobulin Light Chain ◽  
Antigenic Region

Autoantibodies against the 70-kD U1 RNP nucleoprotein autoantigen and DNA were elicited in normal BALB/c mice with a purified Ig light chain. This light chain, derived from a lupus-prone MRL-lpr/lpr mouse, has two distinctive properties: it contains an idiotypic marker recognized by a monoclonal MRL-lpr/lpr anti-snRNP autoantibody, and the amino acid sequence of its third hypervariable region (CDR3) is homologous to a sequence in an antigenic region of the 70-kD U1 RNP polypeptide. The results demonstrate that an Ig idiotype that mimics an autoantigen can induce autoimmunization.

scholarly journals Sequence studies of the Fd section of the heavy chain of rabbit immunoglobulin G

1970 ◽  
Vol 116 (2) ◽  
pp. 249-259 ◽  
Author(s):  
R. G. Fruchter ◽  
S. A. Jackson ◽  
L. E. Mole ◽  
R. R. Porter
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Heavy Chain ◽  
Immunoglobulin G ◽  
Partial Amino Acid Sequence ◽  
Limited Region ◽  
Heavy Chains ◽  
Total Sequence ◽  
Continuous Sequence ◽  
Rabbit Immunoglobulin

A partial amino acid sequence was given by Cebra, Steiner & Porter (1968b) of the N-terminal half of the heavy chain of rabbit immunoglobulin G. This was extended and in part corrected to give a continuous sequence of 136 residues, which together with other work accounts for three-quarters of the total sequence. Evidence is given suggesting that there is a limited region of 10–15 residues that are exceptionally variable in the heavy chains from pooled rabbit immunoglobulin G.

scholarly journals A λ Bence-Jones protein in guinea pigs

1975 ◽  
Vol 151 (3) ◽  
pp. 751-753 ◽  
Author(s):  
F K Stevenson ◽  
L E Mole ◽  
C M Raymont ◽  
G T Stevenson
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Light Chain ◽  
Guinea Pigs ◽  
Lymphocytic Leukaemia ◽  
Immunoglobulin Light Chain ◽  
Bence Jones Protein ◽  
Close Analogy ◽  
Leukaemic Cells ◽  
V Region

1. The L2C lymphocytic leukaemia in strain-2 guinea pigs is accompanied by a protein in the urine resembling a homogenous immunoglobulin light chain. 2. The amino acid sequence over the first 20 residues demonstrates a close analogy with a human λ chain of V region subgroup IV. 3. The protein is apparently synthesized by the leukaemic cells and thus represents a monoclonal light chain, i.e. a Bence-Jones protein.

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