Compensatory increase in tyrosine hydroxylase activity in rat brain after intraventricular injections of 6-hydroxydopamine

Science ◽  
1980 ◽  
Vol 207 (4430) ◽  
pp. 537-540 ◽  
Author(s):  
A. Acheson ◽  
M. Zigmond ◽  
E. Stricker
Keyword(s):  
Tyrosine Hydroxylase ◽  
Rat Brain ◽  
Hydroxylase Activity ◽  
Compensatory Increase ◽  
Tyrosine Hydroxylase Activity ◽  
Intraventricular Injections ◽  
6 Hydroxydopamine

Increase in tyrosine hydroxylase activity in the locus coeruleus of the rat brain after contralateral lesioning

1975 ◽  
Vol 93 (3) ◽  
pp. 564-569 ◽  
Author(s):  
Michel Buda ◽  
Bernard Roussel ◽  
Bernard Renaud ◽  
Jean-Fran¢ois Pujol
Keyword(s):  
Tyrosine Hydroxylase ◽  
Locus Coeruleus ◽  
Rat Brain ◽  
Hydroxylase Activity ◽  
Tyrosine Hydroxylase Activity

scholarly journals Enhancement of rat brain catecholamine synthesis by administration of small doses of tyrosine and evidence for substrate inhibition of tyrosine hydroxylase activity by large doses of the amino acid

1982 ◽  
Vol 206 (1) ◽  
pp. 165-168 ◽  
Author(s):  
Abdulla A.-B. Badawy ◽  
David L. Williams
Keyword(s):  
Amino Acid ◽  
Tyrosine Hydroxylase ◽  
Rat Brain ◽  
Substrate Inhibition ◽  
Hydroxylase Activity ◽  
Catecholamine Synthesis ◽  
Tyrosine Hydroxylase Activity ◽  
Small Doses

Rat brain catecholamine synthesis is enhanced by small doses of tyrosine, but not by doses of 50mg/kg body wt. and above. It is suggested that these latter doses overcome the above enhancement by causing a substrate inhibition of tyrosine hydroxylase activity.

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