Effect of atypical neuroleptics carbidine and sulpiride on striatal synaptosomal tyrosine hydroxylase activity in the rat brain

1984 ◽  
Vol 98 (3) ◽  
pp. 1208-1211
Author(s):  
A. A. Meos ◽  
V. S. Kudrin ◽  
K. S. Raevskii
Keyword(s):  
Tyrosine Hydroxylase ◽  
Rat Brain ◽  
Atypical Neuroleptics ◽  
Hydroxylase Activity ◽  
Tyrosine Hydroxylase Activity

Increase in tyrosine hydroxylase activity in the locus coeruleus of the rat brain after contralateral lesioning

1975 ◽  
Vol 93 (3) ◽  
pp. 564-569 ◽  
Author(s):  
Michel Buda ◽  
Bernard Roussel ◽  
Bernard Renaud ◽  
Jean-Fran¢ois Pujol
Keyword(s):  
Tyrosine Hydroxylase ◽  
Locus Coeruleus ◽  
Rat Brain ◽  
Hydroxylase Activity ◽  
Tyrosine Hydroxylase Activity

scholarly journals Enhancement of rat brain catecholamine synthesis by administration of small doses of tyrosine and evidence for substrate inhibition of tyrosine hydroxylase activity by large doses of the amino acid

1982 ◽  
Vol 206 (1) ◽  
pp. 165-168 ◽  
Author(s):  
Abdulla A.-B. Badawy ◽  
David L. Williams
Keyword(s):  
Amino Acid ◽  
Tyrosine Hydroxylase ◽  
Rat Brain ◽  
Substrate Inhibition ◽  
Hydroxylase Activity ◽  
Catecholamine Synthesis ◽  
Tyrosine Hydroxylase Activity ◽  
Small Doses

Rat brain catecholamine synthesis is enhanced by small doses of tyrosine, but not by doses of 50mg/kg body wt. and above. It is suggested that these latter doses overcome the above enhancement by causing a substrate inhibition of tyrosine hydroxylase activity.

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