Virus-induced diabetes mellitus: reovirus infection of pancreatic beta cells in mice

Science ◽  
1978 ◽  
Vol 201 (4355) ◽  
pp. 529-531 ◽  
Author(s):  
T Onodera ◽  
A. Jenson ◽  
J. Yoon ◽  
A. Notkins
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Reovirus Infection

scholarly journals The Potency of Senggani (Melastoma malabathricum L) Leaves in Repair of Pancreatic Beta Cells for Diabetes Mellitus Patients: A Narrative Review

2020 ◽  
Vol 7 (2) ◽  
pp. 61-70
Author(s):  
Galuh Rizal Prayoga ◽  
Aziz Syamsul Huda ◽  
Syndilona Br Sitepu
Keyword(s):  
Diabetes Mellitus ◽  
Binding Site ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Docking Simulation ◽  
The Body ◽  
Inhibition Mechanism ◽  
Active Compounds ◽  
Glucose Levels ◽  
Melastoma Malabathricum

Diabetes mellitus is often caused by damage to pancreatic beta cells which play a role in secreting insulin in the body. Damage to pancreatic beta cells causes the body to lack insulin. Dipeptidyl peptidase-4 (DPP-4) is a peptidase enzyme complex located on the surface of the cell membrane. Inhibition of the DPP4 enzyme will increase blood GLP-1 levels and induce regeneration of pancreatic beta cells. Senggani leaf (Melastoma malabathricum) boiled water is believed by the people of the Ciamis area to be used as a diabetes medicine. There have been many studies and reviews related to Senggani (Melastoma malabathricum) and its potential. This review focuses on the discussion of Senggani as an antidiabetic by analyzing the reduction in glucose levels and the repair ability of pancreatic beta cells. The results of the literature study that show that senggani leaves have the ability to reduce blood glucose levels and repair activity of pancreatic beta cells through the DPP-4 enzyme inhibition mechanism supported by molecular docking simulation data. There are 12 active compounds that have a binding site similarity above 50% with the comparison compound vildagliptin. Rutin is the best active compound which has a 100% similarity of the binding site. Based on in vivo research and toxicity analysis on the admetsar database, senggani leaf extract and active compounds of senggani leaves have low toxicity, making it safe to be used as antidiabetic herbal preparations.

scholarly journals Nano-curcumin safely prevents streptozotocin-induced inflammation and apoptosis in pancreatic beta cells for effective management of Type 1 diabetes mellitus

2017 ◽  
Vol 174 (13) ◽  
pp. 2074-2084 ◽  
Author(s):  
Raghu Ganugula ◽  
Meenakshi Arora ◽  
Patcharawalai Jaisamut ◽  
Ruedeekorn Wiwattanapatapee ◽  
Heather G Jørgensen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Effective Management

scholarly journals Isodisomy of chromosome 6 in a newborn with methylmalonic acidemia and agenesis of pancreatic beta cells causing diabetes mellitus.

1994 ◽  
Vol 94 (1) ◽  
pp. 418-421 ◽  
Author(s):  
M J Abramowicz ◽  
M Andrien ◽  
E Dupont ◽  
H Dorchy ◽  
J Parma ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Methylmalonic Acidemia ◽  
Chromosome 6

Diabetes Mellitus

2021 ◽  
pp. 1-31
Author(s):  
Ruksar Salim Damji ◽  
Shamiha Chowdhury ◽  
Zaib-Un-Nisa Munawar Hussain
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cells ◽  
21St Century ◽  
Economic Burden ◽  
Metabolic Disorder ◽  
Pancreatic Beta Cells ◽  
Herbal Medicines ◽  
Drug Reactions ◽  
Healthcare Expenditures ◽  
Autoimmune Destruction

Diabetes mellitus is a chronic metabolic disorder which is at present rapidly growing to an alarming epidemic level. Various pathogenic processes are involved in the development of diabetes mellitus. This spectrums from autoimmune destruction of pancreatic beta cells with consequent deficiency of insulin to abnormalities that lead to resistance to the action of insulin. In the 21st century, the astounding rise in obesity, poor diet, and inactive lifestyles have increased the prevalence dramatically. Although several therapies are in use, Western medications are associated with adverse drug reactions and high cost of treatment. Therefore, there is currently a growing interest in herbal medicines to replace or supplement the Western medications. Extensive research is essential to enhance diagnoses, treatment, and to lessen healthcare expenditures. This chapter provides an overview of the classification, diagnosis, symptoms, complications, and economic burden of diabetes mellitus. Additionally, the authors discuss the current and upcoming therapies to treat this metabolic disorder.

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