Diabetes mellitus during pregnancy known as GDM is a severe disorder that develops during pregnancy and its prevalence is rapidly increasing all around the world. It arises due to two major metabolic defects; acute resistance of insulin and dysfunctioning of beta cells. Numerous organs are additionally associated with the pathological process of GDM. There are two types of factors that are associated with GDM that are modifiable and non-modifiable. GDM can cause serious long-term complications to both fetus and mother due to maternal hereditary proneness linked with the environment and fetoplacental aspects. The purpose of this manuscript is to audit GDM in detail and to provide a logical information with refreshed exploration from various angles.
Impaired proliferation of pancreatic beta cells, by reduced placental growth factor in pre-eclampsia, as a cause for gestational diabetes mellitus