Crystal structure of bee-venom phospholipase A2: correction

Science ◽  
1991 ◽  
Vol 252 (5007) ◽  
pp. 764-764 ◽  
Author(s):  
D. Scott ◽  
Z. Otwinowski ◽  
M. Gelb ◽  
P. Sigler
Keyword(s):  
Crystal Structure ◽  
Phospholipase A2 ◽  
Bee Venom

Crystal structure of bee-venom phospholipase A2 in a complex with a transition-state analogue

Science ◽  
1990 ◽  
Vol 250 (4987) ◽  
pp. 1563-1566 ◽  
Author(s):  
D. Scott ◽  
Z. Otwinowski ◽  
M. Gelb ◽  
P. Sigler
Keyword(s):  
Crystal Structure ◽  
Transition State ◽  
Phospholipase A2 ◽  
Bee Venom ◽  
Transition State Analogue

scholarly journals The 2.5 A crystal structure of a dimeric phospholipase A2 from the venom of Crotalus atrox.

1981 ◽  
Vol 256 (16) ◽  
pp. 8602-8607
Author(s):  
C. Keith ◽  
D.S. Feldman ◽  
S. Deganello ◽  
J. Glick ◽  
K.B. Ward ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Phospholipase A2 ◽  
Crotalus Atrox

Crystal structure of cobra-venom phospholipase A2 in a complex with a transition-state analogue

Science ◽  
1990 ◽  
Vol 250 (4987) ◽  
pp. 1560-1563 ◽  
Author(s):  
S. White ◽  
D. Scott ◽  
Z. Otwinowski ◽  
M. Gelb ◽  
P. Sigler
Keyword(s):  
Crystal Structure ◽  
Transition State ◽  
Phospholipase A2 ◽  
Cobra Venom ◽  
Transition State Analogue

scholarly journals Apamin Enhances Neurite Outgrowth and Regeneration after Laceration Injury in Cortical Neurons

Toxins ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 603
Author(s):  
Hyunseong Kim ◽  
Jin Young Hong ◽  
Junseon Lee ◽  
Wan-Jin Jeon ◽  
In-Hyuk Ha
Keyword(s):  
Phospholipase A2 ◽  
Neurite Outgrowth ◽  
Cortical Neurons ◽  
Neurological Diseases ◽  
Minor Component ◽  
Underlying Mechanism ◽  
Bee Venom ◽  
Dependent Manner ◽  
Neuroprotective Effects ◽  
Wide Range

Apamin is a minor component of bee venom and is a polypeptide with 18 amino acid residues. Although apamin is considered a neurotoxic compound that blocks the potassium channel, its neuroprotective effects on neurons have been recently reported. However, there is little information about the underlying mechanism and very little is known regarding the toxicological characterization of other compounds in bee venom. Here, cultured mature cortical neurons were treated with bee venom components, including apamin, phospholipase A2, and the main component, melittin. Melittin and phospholipase A2 from bee venom caused a neurotoxic effect in dose-dependent manner, but apamin did not induce neurotoxicity in mature cortical neurons in doses of up to 10 µg/mL. Next, 1 and 10 µg/mL of apamin were applied to cultivate mature cortical neurons. Apamin accelerated neurite outgrowth and axon regeneration after laceration injury. Furthermore, apamin induced the upregulation of brain-derived neurotrophic factor and neurotrophin nerve growth factor, as well as regeneration-associated gene expression in mature cortical neurons. Due to its neurotherapeutic effects, apamin may be a promising candidate for the treatment of a wide range of neurological diseases.

Molecular model of the interaction of bee venom phospholipase A2 with manoalide

1993 ◽  
Vol 36 (13) ◽  
pp. 1866-1879 ◽  
Author(s):  
Angel R. Ortiz ◽  
M. Teresa Pisabarro ◽  
Federico Gago
Keyword(s):  
Phospholipase A2 ◽  
Molecular Model ◽  
Bee Venom

scholarly journals Activation of bee venom phospholipase A2 through a peptide-enzyme complex

FEBS Letters ◽  
1995 ◽  
Vol 372 (1) ◽  
pp. 131-134 ◽  
Author(s):  
Ismael Mingarro ◽  
Enrique Pérez-Payá ◽  
Clemencia Pinilla ◽  
Jon R. Appel ◽  
Richard A. Houghten ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Bee Venom ◽  
Enzyme Complex
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