Molecular model of the interaction of bee venom phospholipase A2 with manoalide

1993 ◽  
Vol 36 (13) ◽  
pp. 1866-1879 ◽  
Author(s):  
Angel R. Ortiz ◽  
M. Teresa Pisabarro ◽  
Federico Gago
Keyword(s):  
Phospholipase A2 ◽  
Molecular Model ◽  
Bee Venom

scholarly journals Apamin Enhances Neurite Outgrowth and Regeneration after Laceration Injury in Cortical Neurons

Toxins ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 603
Author(s):  
Hyunseong Kim ◽  
Jin Young Hong ◽  
Junseon Lee ◽  
Wan-Jin Jeon ◽  
In-Hyuk Ha
Keyword(s):  
Phospholipase A2 ◽  
Neurite Outgrowth ◽  
Cortical Neurons ◽  
Neurological Diseases ◽  
Minor Component ◽  
Underlying Mechanism ◽  
Bee Venom ◽  
Dependent Manner ◽  
Neuroprotective Effects ◽  
Wide Range

Apamin is a minor component of bee venom and is a polypeptide with 18 amino acid residues. Although apamin is considered a neurotoxic compound that blocks the potassium channel, its neuroprotective effects on neurons have been recently reported. However, there is little information about the underlying mechanism and very little is known regarding the toxicological characterization of other compounds in bee venom. Here, cultured mature cortical neurons were treated with bee venom components, including apamin, phospholipase A2, and the main component, melittin. Melittin and phospholipase A2 from bee venom caused a neurotoxic effect in dose-dependent manner, but apamin did not induce neurotoxicity in mature cortical neurons in doses of up to 10 µg/mL. Next, 1 and 10 µg/mL of apamin were applied to cultivate mature cortical neurons. Apamin accelerated neurite outgrowth and axon regeneration after laceration injury. Furthermore, apamin induced the upregulation of brain-derived neurotrophic factor and neurotrophin nerve growth factor, as well as regeneration-associated gene expression in mature cortical neurons. Due to its neurotherapeutic effects, apamin may be a promising candidate for the treatment of a wide range of neurological diseases.

Crystal structure of bee-venom phospholipase A2: correction

Science ◽  
1991 ◽  
Vol 252 (5007) ◽  
pp. 764-764 ◽  
Author(s):  
D. Scott ◽  
Z. Otwinowski ◽  
M. Gelb ◽  
P. Sigler
Keyword(s):  
Crystal Structure ◽  
Phospholipase A2 ◽  
Bee Venom

scholarly journals Activation of bee venom phospholipase A2 through a peptide-enzyme complex

FEBS Letters ◽  
1995 ◽  
Vol 372 (1) ◽  
pp. 131-134 ◽  
Author(s):  
Ismael Mingarro ◽  
Enrique Pérez-Payá ◽  
Clemencia Pinilla ◽  
Jon R. Appel ◽  
Richard A. Houghten ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Bee Venom ◽  
Enzyme Complex

Increased specificity of diagnostic tests with recombinant major bee venom allergen phospholipase A2

1997 ◽  
Vol 27 (8) ◽  
pp. 915-920 ◽  
Author(s):  
U. MÜLLER ◽  
M. FRICKER ◽  
D. WYMANN ◽  
K. BLASER ◽  
R. CRAMERI
Keyword(s):  
Phospholipase A2 ◽  
Diagnostic Tests ◽  
Bee Venom ◽  
Venom Allergen

Bee venom phospholipase A2-specific T cell clones from human allergic and non-allergic individuals: cytokine patterns change in response to the antigen concentration

1992 ◽  
Vol 22 (6) ◽  
pp. 1357-1363 ◽  
Author(s):  
José M. Carballido ◽  
Nicole Carballido-Perrig ◽  
GeróNimo Terres ◽  
Christoph H. Heusser ◽  
Kurt Blaser
Keyword(s):  
T Cell ◽  
Phospholipase A2 ◽  
Bee Venom ◽  
Antigen Concentration ◽  
T Cell Clones ◽  
Cell Clones

scholarly journals Preventive Effects of Bee Venom Derived Phospholipase A2 on Oxaliplatin-Induced Neuropathic Pain in Mice

Toxins ◽  
2016 ◽  
Vol 8 (1) ◽  
pp. 27 ◽  
Author(s):  
Dongxing Li ◽  
Woojin Kim ◽  
Dasom Shin ◽  
Yongjae Jung ◽  
Hyunsu Bae ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Phospholipase A2 ◽  
Bee Venom ◽  
Preventive Effects
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