Control of larval development by chemosensory neurons in Caenorhabditis elegans

Science ◽  
1991 ◽  
Vol 251 (4998) ◽  
pp. 1243-1246 ◽  
Author(s):  
C. Bargmann ◽  
H. Horvitz
Keyword(s):  
Caenorhabditis Elegans ◽  
Larval Development ◽  
Chemosensory Neurons

scholarly journals NHR-40, a Caenorhabditis elegans supplementary nuclear receptor, regulates embryonic and early larval development

2006 ◽  
Vol 123 (9) ◽  
pp. 689-701 ◽  
Author(s):  
Eva Brožová ◽  
Kateřina Šimečková ◽  
Zdeněk Kostrouch ◽  
Joseph Edward Rall ◽  
Marta Kostrouchová
Keyword(s):  
Caenorhabditis Elegans ◽  
Larval Development ◽  
Nuclear Receptor ◽  
Early Larval Development

scholarly journals Maternal Caffeine Intake Disrupts Eggshell Integrity and Retards Larval Development by Reducing Yolk Production in a Caenorhabditis elegans Model

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1334 ◽  
Author(s):  
Hyemin Min ◽  
Esther Youn ◽  
Yhong-Hee Shim
Keyword(s):  
Growth Rate ◽  
Transcription Factor ◽  
Rna Interference ◽  
Caenorhabditis Elegans ◽  
Larval Development ◽  
Caffeine Intake ◽  
Young Mother ◽  
Psychoactive Substance ◽  
Intergenerational Effects ◽  
F2 Generation

During pregnancy, most women are exposed to caffeine, which is a widely consumed psychoactive substance. However, the consequences of maternal caffeine intake on the child remain largely unknown. Here, we investigated the intergenerational effects of maternal caffeine intake on offspring in a Caenorhabditis elegans model. We treated a young mother (P0) with 10 mM of caffeine equivalent to 2–5 cans of commercial energy drinks and examined its reproduction and growth rate from P0 to F2 generation. The fertility decreased and embryonic lethality increased by defective oocytes and eggshell integrity in caffeine-ingested mothers, and F1 larval development severely retarded. These results were due to decreased production of vitellogenin protein (yolk) in caffeine-ingested mothers. Furthermore, effects of RNA interference of vitellogenin (vit) genes, vit-1 to vit-6, in P0 mothers can mimic those by caffeine-ingested mothers. In addition, RNA interference (RNAi) depletion of unc-62 (human Meis homeobox), a transcriptional activator for vit genes, also showed similar effects induced by caffeine intake. Taken together, maternal caffeine intake reduced yolk production mediated by the UNC-62 transcription factor, thereby disrupting oocyte and eggshell integrity and retarding larval development. Our study suggests the clinical significance of caffeine intake for prospective mothers.

scholarly journals Cholesterol-responsive metabolic proteins are required for larval development in Caenorhabditis elegans

2013 ◽  
Vol 36 (5) ◽  
pp. 410-416 ◽  
Author(s):  
Ichiro Kawasaki ◽  
Myung-Hwan Jeong ◽  
Yu-Joun Yun ◽  
Yun-Kyung Shin ◽  
Yhong-Hee Shim
Keyword(s):  
Caenorhabditis Elegans ◽  
Larval Development

Caenorhabditis elegans senses protons through amphid chemosensory neurons

Neuroreport ◽  
2000 ◽  
Vol 11 (10) ◽  
pp. 2229-2232 ◽  
Author(s):  
Yoshihiro Sambongi ◽  
Kenji Takeda ◽  
Tokumitsu Wakabayashi ◽  
Ikuo Ueda ◽  
Yoh Wada ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Chemosensory Neurons

scholarly journals A trade-off switch of two immunological memories in Caenorhabditis elegans reinfected by bacterial pathogens

2020 ◽  
Vol 295 (50) ◽  
pp. 17323-17336
Author(s):  
Jinyuan Yan ◽  
Ninghui Zhao ◽  
Zhongshan Yang ◽  
Yuhong Li ◽  
Hua Bai ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Caenorhabditis Elegans ◽  
Pathogenic Bacteria ◽  
Immunological Memory ◽  
Innate Immune ◽  
Microbial Pathogens ◽  
Immune Memory ◽  
Microbial Infection ◽  
Trade Off ◽  
Chemosensory Neurons

Recent studies have suggested that innate immune responses exhibit characteristics associated with memory linked to modulations in both vertebrates and invertebrates. However, the diverse evolutionary paths taken, particularly within the invertebrate taxa, should lead to similarly diverse innate immunity memory processes. Our understanding of innate immune memory in invertebrates primarily comes from studies of the fruit fly Drosophila melanogaster, the generality of which is unclear. Caenorhabditis elegans typically inhabits soil harboring a variety of fatal microbial pathogens; for this invertebrate, the innate immune system and aversive behavior are the major defensive strategies against microbial infection. However, their characteristics of immunological memory remains infantile. Here we discovered an immunological memory that promoted avoidance and suppressed innate immunity during reinfection with bacteria, which we revealed to be specific to the previously exposed pathogens. During this trade-off switch of avoidance and innate immunity, the chemosensory neurons AWB and ADF modulated production of serotonin and dopamine, which in turn decreased expression of the innate immunity-associated genes and led to enhanced avoidance via the downstream insulin-like pathway. Therefore, our current study profiles the immune memories during C. elegans reinfected by pathogenic bacteria and further reveals that the chemosensory neurons, the neurotransmitter(s), and their associated molecular signaling pathways are responsible for a trade-off switch between the two immunological memories.

Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans

2014 ◽  
Vol 60 (1) ◽  
Author(s):  
Romina E. D’Almeida ◽  
María R. Alberto ◽  
Phillip Morgan ◽  
Margaret Sedensky ◽  
María I. Isla
Keyword(s):  
Caenorhabditis Elegans ◽  
Larval Development ◽  
Free Living ◽  
Egg Hatching ◽  
C Elegans ◽  
Therapeutic Drugs ◽  
Aerial Parts ◽  
Free Living Nematode ◽  
Development Processes ◽  
Anthelmintic Effect

AbstractZuccagnia punctata Cav. (Fabaceae), commonly called jarilla macho or pus-pus, is being used in traditional medicine as an antiseptic, anti-inflammatory and to relieve muscle and bone pain. The aim of this work was to study the anthelmintic effects of three structurally related flavonoids present in aerial parts of Z. punctata Cav. The biological activity of the flavonoids 7-hydroxyflavanone (HF), 3,7-dihydroxyflavone (DHF) and 2´,4´-dihydroxychalcone (DHC) was examined in the free-living nematode Caenorhabditis elegans. Our results showed that among the assayed flavonoids, only DHC showed an anthelmintic effect and alteration of egg hatching and larval development processes in C. elegans. DHC was able to kill 50% of adult nematodes at a concentration of 17 μg/mL. The effect on larval development was observed after 48 h in the presence of 25 and 50 μg/mL DHC, where 33.4 and 73.4% of nematodes remained in the L3 stage or younger. New therapeutic drugs with good efficacy against drug-resistant nematodes are urgently needed. Therefore, DHC, a natural compound present in Z. punctata, is proposed as a potential anthelmintic drug.

scholarly journals Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans

Development ◽  
2008 ◽  
Vol 135 (13) ◽  
pp. 2239-2249 ◽  
Author(s):  
D. S. Patel ◽  
L. L. Fang ◽  
D. K. Svy ◽  
G. Ruvkun ◽  
W. Li
Keyword(s):  
Caenorhabditis Elegans ◽  
Larval Development ◽  
Genetic Identification ◽  
Steroidogenic Enzyme

An automated microfluidic platform for calcium imaging of chemosensory neurons in Caenorhabditis elegans

Lab on a Chip ◽  
2010 ◽  
Vol 10 (20) ◽  
pp. 2758 ◽  
Author(s):  
Trushal Vijaykumar Chokshi ◽  
Daphne Bazopoulou ◽  
Nikos Chronis
Keyword(s):  
Caenorhabditis Elegans ◽  
Calcium Imaging ◽  
Microfluidic Platform ◽  
Chemosensory Neurons
Sign in / Sign up

Export Citation Format

Share Document