Identification of a major growth factor for AIDS-Kaposi's sarcoma cells as oncostatin M

Science ◽  
1992 ◽  
Vol 255 (5050) ◽  
pp. 1430-1432 ◽  
Author(s):  
B. Nair ◽  
A. DeVico ◽  
S Nakamura ◽  
T. Copeland ◽  
Y Chen ◽  
...  
Keyword(s):  
Growth Factor ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Oncostatin M ◽  
Sarcoma Cells

scholarly journals Glucocorticoids Induce Kaposi's Sarcoma Cell Proliferation Through the Regulation of Transforming Growth Factor-β

Blood ◽  
1997 ◽  
Vol 89 (5) ◽  
pp. 1491-1500 ◽  
Author(s):  
Jie Cai ◽  
Tong Zheng ◽  
Martin Lotz ◽  
Ya Zhang ◽  
Rizwan Masood ◽  
...  
Keyword(s):  
Growth Factor ◽  
Plasminogen Activator ◽  
Kaposi's Sarcoma ◽  
Transforming Growth Factor ◽  
Interleukin 1 ◽  
Kaposi’S Sarcoma ◽  
Plasminogen Activator Inhibitor ◽  
Transforming Growth Factor Β ◽  
Oncostatin M ◽  
Autocrine Growth

Glucocorticoid (GC) use is known to induce or enhance the growth of Kaposi's sarcoma (KS) in many clinical settings including human immunodeficiency virus infection, collagen vascular disease, lymphoproliferative disorders, and renal transplantation. Because GCs may induce immune suppression and thus tumor growth, we determined whether GCs had a direct effect on KS growth. We found that GCs directly induce the growth of KS cell lines. In examining the mechanism of action of GCs, we did not observe induction of known autocrine growth factors for KS including interleukin-1 (IL-1), IL-6, oncostatin-M, basic fibroblast growth factor (bFGF ), and vascular endothelial growth factor (VEGF ). We thus examined factor(s) that inhibit KS growth. Transforming growth factor-β (TGF-β) is produced by KS cells and has pleiotropic effects, including inhibiting the growth of hematopoietic and endothelial cells. We show that TGF-β is produced by KS cells in both the latent and active forms, and that TGF-β is an autocrine growth inhibitory factor. We then studied the effects of GCs on the regulation of TGF-β and found that GCs do not inhibit TGF-β transcription, but significantly inhibit TGF-β activation. This effect is mediated through regulation of the TGF-β activation pathway. TGF-β is activated by plasmin which is positively regulated by plasminogen activator (PA) and PA receptor (PAR), and negatively regulated by plasminogen activator inhibitor (PAI). GCs downregulated PAR and upregulated PAI. Thus, glucocorticoids enhance KS cell growth through the regulation of TGF-β activation.

scholarly journals Glucocorticoids Induce Kaposi's Sarcoma Cell Proliferation Through the Regulation of Transforming Growth Factor-β

Blood ◽  
1997 ◽  
Vol 89 (5) ◽  
pp. 1491-1500 ◽  
Author(s):  
Jie Cai ◽  
Tong Zheng ◽  
Martin Lotz ◽  
Ya Zhang ◽  
Rizwan Masood ◽  
...  
Keyword(s):  
Growth Factor ◽  
Plasminogen Activator ◽  
Kaposi's Sarcoma ◽  
Transforming Growth Factor ◽  
Interleukin 1 ◽  
Kaposi’S Sarcoma ◽  
Plasminogen Activator Inhibitor ◽  
Transforming Growth Factor Β ◽  
Oncostatin M ◽  
Autocrine Growth

Abstract Glucocorticoid (GC) use is known to induce or enhance the growth of Kaposi's sarcoma (KS) in many clinical settings including human immunodeficiency virus infection, collagen vascular disease, lymphoproliferative disorders, and renal transplantation. Because GCs may induce immune suppression and thus tumor growth, we determined whether GCs had a direct effect on KS growth. We found that GCs directly induce the growth of KS cell lines. In examining the mechanism of action of GCs, we did not observe induction of known autocrine growth factors for KS including interleukin-1 (IL-1), IL-6, oncostatin-M, basic fibroblast growth factor (bFGF ), and vascular endothelial growth factor (VEGF ). We thus examined factor(s) that inhibit KS growth. Transforming growth factor-β (TGF-β) is produced by KS cells and has pleiotropic effects, including inhibiting the growth of hematopoietic and endothelial cells. We show that TGF-β is produced by KS cells in both the latent and active forms, and that TGF-β is an autocrine growth inhibitory factor. We then studied the effects of GCs on the regulation of TGF-β and found that GCs do not inhibit TGF-β transcription, but significantly inhibit TGF-β activation. This effect is mediated through regulation of the TGF-β activation pathway. TGF-β is activated by plasmin which is positively regulated by plasminogen activator (PA) and PA receptor (PAR), and negatively regulated by plasminogen activator inhibitor (PAI). GCs downregulated PAR and upregulated PAI. Thus, glucocorticoids enhance KS cell growth through the regulation of TGF-β activation.

scholarly journals Vascular Endothelial Growth Factor-C Stimulates the Migration and Proliferation of Kaposi’s Sarcoma Cells

1999 ◽  
Vol 274 (39) ◽  
pp. 27617-27622 ◽  
Author(s):  
Serena Marchiò ◽  
Luca Primo ◽  
Marco Pagano ◽  
Giorgio Palestro ◽  
Adriana Albini ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Vascular Endothelial ◽  
Factor C ◽  
Sarcoma Cells ◽  
Endothelial Growth Factor

Diacylglycerol kinases are essential for hepatocyte growth factor-dependent proliferation and motility of Kaposi’s sarcoma cells

2011 ◽  
Vol 102 (7) ◽  
pp. 1329-1336 ◽  
Author(s):  
Gianluca Baldanzi ◽  
Stefano Pietronave ◽  
Deborah Locarno ◽  
Simone Merlin ◽  
Paolo Porporato ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Sarcoma Cells ◽  
Hepatocyte Growth

Kaposi's sarcoma cells: long-term culture with growth factor from retrovirus-infected CD4+ T cells

Science ◽  
1988 ◽  
Vol 242 (4877) ◽  
pp. 426-430 ◽  
Author(s):  
S Nakamura ◽  
S. Salahuddin ◽  
P Biberfeld ◽  
B Ensoli ◽  
P. Markham ◽  
...  
Keyword(s):  
T Cells ◽  
Growth Factor ◽  
Cd4 T Cells ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Long Term Culture ◽  
Sarcoma Cells

Rapamycin promotes autophagy cell death of Kaposi’s sarcoma cells through P75NTR activation

2021 ◽  
Author(s):  
Simona Lupinacci ◽  
Anna Perri ◽  
Giuseppina Toteda ◽  
Donatella Vizza ◽  
Danilo Lofaro ◽  
...  
Keyword(s):  
Cell Death ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Sarcoma Cells
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