Selective C-H Fluorination of Pyridines and Diazines Inspired by a Classic Amination Reaction

Science ◽  
2013 ◽  
Vol 342 (6161) ◽  
pp. 956-960 ◽  
Author(s):  
P. S. Fier ◽  
J. F. Hartwig
Keyword(s):  
Amination Reaction

Pd Catalyzed N1/N4 Arylation of Piperazine for Synthesis of Drugs, Biological and Pharmaceutical Targets: An Overview of Buchwald Hartwig Amination Reaction of Piperazine in Drug Synthesis

2018 ◽  
Vol 15 (2) ◽  
pp. 208-220 ◽  
Author(s):  
Vaibhav Mishra ◽  
Tejpal Singh Chundawat
Keyword(s):  
Bond Formation ◽  
Catalyst Design ◽  
Biologically Active ◽  
Reaction Conditions ◽  
Biological Targets ◽  
Amination Reaction ◽  
Drug Synthesis ◽  
Substituted Piperazine ◽  
Approved Drugs ◽  
Fda Approved Drugs

Background: Substituted piperazine heterocycles are among the most significant structural components of pharmaceuticals. N1/N4 substituted piperazine containing drugs and biological targets are ranked 3rd in the top most frequent nitrogen heterocycles in U.S. FDA approved drugs. The high demand of N1/N4 substituted piperazine containing biologically active compounds and U.S. FDA approved drugs, has prompted the development of Pd catalyzed C-N bond formation reactions for their synthesis. Buchwald-Hartwig reaction is the key tool for the synthesis of these compounds. Objective: This review provides strategies for Pd catalyzed C-N bond formation at N1/N4 of piperazine in the synthesis of drugs and biological targets with diverse use of catalyst-ligand system and reaction parameters. Conclusion: It is clear from the review that a vast amount of work has been done in the synthesis of N1/N4 substituted piperazine containing targets under the Pd catalyzed Buchwald-Hartwig amination of aryl halides by using different catalyst-ligand systems. These methods have become increasingly versatile as a result of innovation in catalyst design and improvements in reaction conditions. This review gives an overview of recent utilization of Buchwald-Hartwig amination reaction in drug/target synthesis.

α-amination reaction of different ketones mediated by carbohydrate Cu2+ complexes

2020 ◽  
Vol 493 ◽  
pp. 111058
Author(s):  
Laura I. Rossi ◽  
Claudio R. Krapacher ◽  
Alejandro M. Granados
Keyword(s):  
Amination Reaction

Synthesis of 1-Substituted 2-(Trifluoromethyl)indoles via a Palladium-Catalyzed Double Amination Reaction

Synthesis ◽  
2010 ◽  
Vol 2010 (09) ◽  
pp. 1521-1525 ◽  
Author(s):  
Xing-Guo Zhang ◽  
Jin-Heng Li ◽  
Shu-Xiang Dong ◽  
Qiong Liu ◽  
Ri-Yuan Tang ◽  
...  
Keyword(s):  
Amination Reaction ◽  
Palladium Catalyzed

A General Strategy for the Synthesis of Amino-Substituted 2-Pyridones Using a Palladium-Catalyzed Amination Reaction.

ChemInform ◽  
2007 ◽  
Vol 38 (38) ◽  
Author(s):  
Young Ha Kim ◽  
Yeong-Joon Kim ◽  
Sung-Youn Chang ◽  
Bum Tae Kim ◽  
Jung-Nyoung Heo
Keyword(s):  
General Strategy ◽  
Amination Reaction ◽  
Palladium Catalyzed

scholarly journals Synthetic Studies on Tricyclic Diterpenoids: Direct Allylic Amination Reaction of Isopimaric Acid Derivatives

ChemistryOpen ◽  
2015 ◽  
Vol 5 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Mariya A. Timoshenko ◽  
Yurii V. Kharitonov ◽  
Makhmut M. Shakirov ◽  
Irina Yu. Bagryanskaya ◽  
Elvira E. Shults
Keyword(s):  
Allylic Amination ◽  
Isopimaric Acid ◽  
Amination Reaction ◽  
Synthetic Studies

scholarly journals Computational investigation of the control of the thermodynamics and microkinetics of the reductive amination reaction by solvent coordination and a co-catalyst

RSC Advances ◽  
2018 ◽  
Vol 8 (64) ◽  
pp. 36662-36674 ◽  
Author(s):  
Esra Boz ◽  
Nurcan Ş. Tüzün ◽  
Matthias Stein
Keyword(s):  
Tertiary Amine ◽  
Reductive Amination ◽  
Computational Investigation ◽  
Reaction Parameters ◽  
Co Catalyst ◽  
Amination Reaction ◽  
Green Production

Green production of tertiary amine from sustainable sources can be controlled by appropriate choice of reaction parameters identified by computational means.

An intramolecular palladium-catalysed aryl amination reaction to produce benzimidazoles

2002 ◽  
Vol 43 (10) ◽  
pp. 1893-1895 ◽  
Author(s):  
Christopher T Brain ◽  
Shirley A Brunton
Keyword(s):  
Amination Reaction ◽  
Aryl Amination

ChemInform Abstract: A Short Asymmetric Synthesis of Octahydroindole Derivatives by Application of Catalytic C(sp3)-H Amination Reaction.

ChemInform ◽  
2014 ◽  
Vol 45 (26) ◽  
pp. no-no
Author(s):  
Marie Mazurais ◽  
Camille Lescot ◽  
Pascal Retailleau ◽  
Philippe Dauban
Keyword(s):  
Asymmetric Synthesis ◽  
Amination Reaction
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