scholarly journals Computational investigation of the control of the thermodynamics and microkinetics of the reductive amination reaction by solvent coordination and a co-catalyst

RSC Advances ◽  
2018 ◽  
Vol 8 (64) ◽  
pp. 36662-36674 ◽  
Author(s):  
Esra Boz ◽  
Nurcan Ş. Tüzün ◽  
Matthias Stein
Keyword(s):  
Tertiary Amine ◽  
Reductive Amination ◽  
Computational Investigation ◽  
Reaction Parameters ◽  
Co Catalyst ◽  
Amination Reaction ◽  
Green Production

Green production of tertiary amine from sustainable sources can be controlled by appropriate choice of reaction parameters identified by computational means.

scholarly journals A STATISTICAL APPROACH FOR OPTIMIZING THE HIGH YIELD GREEN PRODUCTION OF THE FLAVOR ESTER BUTYL BUTYRATE

2017 ◽  
Vol 79 (7) ◽  
Author(s):  
Ida Nurhazwani Abd Rahman ◽  
Fatin Myra Abd Manan ◽  
Nur Haziqah Che Marzuki ◽  
Naji A. Mahat ◽  
Nursyafreena Attan ◽  
...  
Keyword(s):  
Molar Ratio ◽  
High Yield ◽  
Esterification Reaction ◽  
Reaction Parameters ◽  
Chemical Route ◽  
Butyl Butyrate ◽  
Novozyme 435 ◽  
Yield Production ◽  
Green Production ◽  
Percentage Conversion

Being the prevailing approach for producing esters such as butyl butyrate, the use of chemical route has been linked to numerous disadvantages. Hence, a green alternative method for higher yield production of butyl butyrate by esterification reaction utilizing Novozyme 435 as biocatalysts in a solvent-less system may prove useful. Such approach can be further improved by optimizing the relevant reaction parameters using the Response Surface Methodology by the Box-Benkhen Design attempted in this present study. The reaction parameters evaluated were: substrate molar ratio, time and temperature, and the response of each parameter was measured as percentage conversion yield. Using the Design Expert 7.1.6 optimization functions, the two sets of optimum conditions selected viz. [i] molar ratio butyric acid:butanol 1:3.93, 9.93 h at 56.09°C and [ii] molar ratio butyric acid:butanol 1:3.35, 9.79 h at 53.90°C had afforded the highest yield of butyl butyrate i.e. 99.62% and 99.55%, respectively. The ester product obtained from the reaction were confirmed as butyl butyrate by FTIR and GC. Therefore, the results substantiated the applicability of the RSM prediction technique as well as efficacy of Novozyme 435 as biocatalysts in the high yield solvent-less synthesis of butyl butyrate, adhering to the philosophy of Green Chemistry.

N-Phenyl-Substituted Pyrrolidines, Piperidines and Azabicyclics by a Tandem Reduction-Double Reductive Amination Reaction.

ChemInform ◽  
2003 ◽  
Vol 34 (26) ◽  
Author(s):  
Richard A. Bunce ◽  
Derrick M. Herron ◽  
Jason R. Lewis ◽  
Sharadsrikar V. Kotturi
Keyword(s):  
Reductive Amination ◽  
Amination Reaction

scholarly journals Copolymerization of CO2 and epoxides mediated by zinc organyls

RSC Advances ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. 3673-3679 ◽  
Author(s):  
Christoph Wulf ◽  
Ulrike Doering ◽  
Thomas Werner
Keyword(s):  
Cyclohexene Oxide ◽  
Reaction Parameters ◽  
Co Catalyst ◽  
Reaction Proceeds ◽  
Halogen Free

Simple zinc organyls (R2Zn) efficiently catalyze the copolymerization of CO2 and cyclohexene oxide. The effect of various reaction parameters has been studied. The reaction proceeds under halogen-free conditions and no co-catalyst is required.

scholarly journals Synthesis and structural characterization of amino-functionalized polysaccharides

2009 ◽  
Vol 7 (1) ◽  
pp. 66-73 ◽  
Author(s):  
Ioana Sisu ◽  
Valentina Udrescu ◽  
Corina Flangea ◽  
Sorin Tudor ◽  
Nicolae Dinca ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Thermal Analysis ◽  
Reductive Amination ◽  
Average Molecular Weight ◽  
Polymer Surface ◽  
Building Blocks ◽  
Collision Induced Dissociation ◽  
Amination Reaction ◽  
Composition And Structure

AbstractA variety of carbohydrates, in particular polysaccharides can be subjected to chemical modification to obtain derivatives with amphiphilic properties, which enable biochemical or biological reactions at the polymer surface. In the present work, a polydisperse maltodextrin mixture of average molecular weight 3000 was coupled with 1,6-hexamethylenediamine (HMD) via reductive amination reaction. Resulting products were characterized by thermal analysis and positive nanoelectrospray quadrupole time-of-flight (Q-TOF) mass spectrometry (MS) and tandem mass spectrometry (MS/MS). Both thermal analysis and MS screening confirmed the formation of the HMD-polysaccharide coupling products. Moreover, HMD-linked polysaccharide chains containing 2 to 26 glucose building blocks were identified by nanoESI Q-TOF MS. MS/MS fragmentation using collision-induced dissociation (CID) at low ion acceleration energies provided strong evidence for HMD-maltodextrin linkage formation and the set of sequence ions diagnostic for the composition and structure of a HMD-linked chain containing 18 glucose residues.

A Sequential Palladium-Catalyzed Alder-Ene-Reductive Amination Reaction†

2005 ◽  
Vol 7 (11) ◽  
pp. 2237-2240 ◽  
Author(s):  
Christoph J. Kressierer ◽  
Thomas J. J. Müller
Keyword(s):  
Reductive Amination ◽  
Amination Reaction ◽  
Palladium Catalyzed

Reductive amination using a combination of CaH2 and noble metal

RSC Advances ◽  
2015 ◽  
Vol 5 (3) ◽  
pp. 2292-2298 ◽  
Author(s):  
Carole Guyon ◽  
Eric Da Silva ◽  
Romain Lafon ◽  
Estelle Métay ◽  
Marc Lemaire
Keyword(s):  
Noble Metal ◽  
Reductive Amination ◽  
Calcium Hydride ◽  
Amination Reaction

Amines were prepared by a reductive amination reaction in the presence of calcium hydride and Pt/C.

Tertiary Amine Synthesis via a Thiourea-Catalyzed Reductive Amination

Synfacts ◽  
2007 ◽  
Vol 2007 (4) ◽  
pp. 0436-0436
Author(s):  
D. Menche ◽  
S. Böhm ◽  
J. Li ◽  
S. Rudolph ◽  
W. Zander
Keyword(s):  
Tertiary Amine ◽  
Reductive Amination
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