scholarly journals Transcription Regulation Through Promoter-Proximal Pausing of RNA Polymerase II

Science ◽  
2008 ◽  
Vol 319 (5871) ◽  
pp. 1791-1792 ◽  
Author(s):  
L. J. Core ◽  
J. T. Lis
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Transcription Regulation

Structure of an RNA polymerase II–RNA inhibitor complex elucidates transcription regulation by noncoding RNAs

2005 ◽  
Vol 13 (1) ◽  
pp. 44-48 ◽  
Author(s):  
Hubert Kettenberger ◽  
Alexander Eisenführ ◽  
Florian Brueckner ◽  
Mirko Theis ◽  
Michael Famulok ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Transcription Regulation ◽  
Noncoding Rnas ◽  
Inhibitor Complex

scholarly journals Genome‐wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling

2013 ◽  
Vol 9 (1) ◽  
pp. 638 ◽  
Author(s):  
Astrid Eijkelenboom ◽  
Michal Mokry ◽  
Elzo de Wit ◽  
Lydia M Smits ◽  
Paulien E Polderman ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Transcription Regulation ◽  
Genome Wide Analysis ◽  
Genome Wide

scholarly journals Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5

2013 ◽  
Vol 20 (7) ◽  
pp. 892-899 ◽  
Author(s):  
Susanne A Kassube ◽  
Martin Jinek ◽  
Jie Fang ◽  
Susan Tsutakawa ◽  
Eva Nogales
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Transcription Regulation ◽  
Dna Helicase

scholarly journals Emerging Views on the CTD Code

2012 ◽  
Vol 2012 ◽  
pp. 1-19 ◽  
Author(s):  
David W. Zhang ◽  
Juan B. Rodríguez-Molina ◽  
Joshua R. Tietjen ◽  
Corey M. Nemec ◽  
Aseem Z. Ansari
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Transcription Regulation ◽  
Chromatin Remodeling ◽  
Posttranslational Modifications ◽  
Rna Processing ◽  
Transcription Initiation ◽  
Protein Complexes ◽  
Pol Ii

The C-terminal domain (CTD) of RNA polymerase II (Pol II) consists of conserved heptapeptide repeats that function as a binding platform for different protein complexes involved in transcription, RNA processing, export, and chromatin remodeling. The CTD repeats are subject to sequential waves of posttranslational modifications during specific stages of the transcription cycle. These patterned modifications have led to the postulation of the “CTD code” hypothesis, where stage-specific patterns define a spatiotemporal code that is recognized by the appropriate interacting partners. Here, we highlight the role of CTD modifications in directing transcription initiation, elongation, and termination. We examine the major readers, writers, and erasers of the CTD code and examine the relevance of describing patterns of posttranslational modifications as a “code.” Finally, we discuss major questions regarding the function of the newly discovered CTD modifications and the fundamental insights into transcription regulation that will necessarily emerge upon addressing those challenges.

scholarly journals Transcription Regulation by the Noncoding RNA SRG1 Requires Spt2-Dependent Chromatin Deposition in the Wake of RNA Polymerase II

2011 ◽  
Vol 31 (6) ◽  
pp. 1288-1300 ◽  
Author(s):  
P. Thebault ◽  
G. Boutin ◽  
W. Bhat ◽  
A. Rufiange ◽  
J. Martens ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Transcription Regulation ◽  
Noncoding Rna
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