Continuous Particle Separation Through Deterministic Lateral Displacement

Science ◽  
2004 ◽  
Vol 304 (5673) ◽  
pp. 987-990 ◽  
Author(s):  
L. R. Huang
Keyword(s):  
Lateral Displacement ◽  
Particle Separation ◽  
Deterministic Lateral Displacement ◽  
Continuous Particle

Limits of Parabolic Flow Theory in Microfluidic Particle Separation: A Computational Study

2013 ◽  
Author(s):  
Ryan S. Pawell ◽  
Tracie J. Barber ◽  
David W. Inglis ◽  
Robert A. Taylor
Keyword(s):  
Computational Study ◽  
Lateral Displacement ◽  
Particle Separation ◽  
Flow Profile ◽  
Flow Rates ◽  
Deterministic Lateral Displacement ◽  
Flow Development ◽  
Separation Threshold ◽  
Parabolic Flow ◽  
Size Based Separation

Microfluidic particle separation technologies are useful for enriching rare cell populations for academic and clinical purposes. In order to separate particles based on size, deterministic lateral displacement (DLD) arrays are designed assuming that the flow profile between posts is parabolic or shifted parabolic (depending on post geometry). The design process also assumes the shape of the normalized flow profile is speed-invariant. The work presented here shows flow profile shapes vary, in arrays with circular and triangular posts, from this assumption at practical flow rates (10 < Re < 100). The root-mean-square error (RMSE) of this assumption in the circular post arrays peaked at 0.144. The RMSE in the triangular post array peaked at 0.136. Flow development occurred more rapidly in circular post arrays when compared to triangular post arrays. Additionally, the changes in critical bumping diameter (DCB) the DLD design metric used to calculate the size-based separation threshold were examined for 10 different row shift fractions (FRS). These errors correspond to a DCB that varies as much as 11.7% in the circular post arrays and 15.1% in the triangular post arrays.

scholarly journals Electrokinetically driven deterministic lateral displacement for particle separation in microfluidic devices

2014 ◽  
Vol 18 (5-6) ◽  
pp. 1195-1200 ◽  
Author(s):  
Srinivas Hanasoge ◽  
Raghavendra Devendra ◽  
Francisco J. Diez ◽  
German Drazer
Keyword(s):  
Lateral Displacement ◽  
Particle Separation ◽  
Microfluidic Devices ◽  
Deterministic Lateral Displacement

scholarly journals Efficient paradigm to enhance particle separation in deterministic lateral displacement arrays

2019 ◽  
Vol 1 (10) ◽  
Author(s):  
Amirali Ebadi ◽  
Mohammad Javad Farshchi Heydari ◽  
Reihaneh Toutouni ◽  
Bahareh Chaichypour ◽  
Morteza Fathipour ◽  
...  
Keyword(s):  
Lateral Displacement ◽  
Particle Separation ◽  
Deterministic Lateral Displacement

Particle separation using virtual deterministic lateral displacement (vDLD)

Lab on a Chip ◽  
2014 ◽  
Vol 14 (9) ◽  
pp. 1595-1603 ◽  
Author(s):  
David J. Collins ◽  
Tuncay Alan ◽  
Adrian Neild
Keyword(s):  
Lateral Displacement ◽  
Particle Separation ◽  
Deterministic Lateral Displacement

Sorting of particles measuring 6.6 μm and 7.0 μm has been achieved in a scheme in which lateral displacement is deterministic.

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