Localization of Long-Term Memory Within the Drosophila Mushroom Body

Science ◽  
2001 ◽  
Vol 294 (5544) ◽  
pp. 1115-1117 ◽  
Author(s):  
A. Pascual
Keyword(s):  
Mushroom Body ◽  
Long Term Memory ◽  
Term Memory

scholarly journals Upregulated energy metabolism in the Drosophila mushroom body is the trigger for long-term memory

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Pierre-Yves Plaçais ◽  
Éloïse de Tredern ◽  
Lisa Scheunemann ◽  
Séverine Trannoy ◽  
Valérie Goguel ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Mushroom Body ◽  
Long Term Memory ◽  
Term Memory

scholarly journals Long-term memory requires sequential protein synthesis in three subsets of mushroom body output neurons in Drosophila

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jie-Kai Wu ◽  
Chu-Yi Tai ◽  
Kuan-Lin Feng ◽  
Shiu-Ling Chen ◽  
Chun-Chao Chen ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Mushroom Body ◽  
Long Term Memory ◽  
Term Memory ◽  
Output Neurons

scholarly journals Drosophila ORB protein in two mushroom body output neurons is necessary for long-term memory formation

2013 ◽  
Vol 110 (19) ◽  
pp. 7898-7903 ◽  
Author(s):  
T.-P. Pai ◽  
C.-C. Chen ◽  
H.-H. Lin ◽  
A.-L. Chin ◽  
J. S.-Y. Lai ◽  
...  
Keyword(s):  
Mushroom Body ◽  
Memory Formation ◽  
Long Term Memory ◽  
Term Memory ◽  
Output Neurons

scholarly journals Systematic functional characterization of the intellectual disability-associated SWI/SNF complex reveals distinct roles for the BAP and PBAP complexes in post-mitotic memory forming neurons of the Drosophila mushroom body

2018 ◽  
Author(s):  
Melissa C. Chubak ◽  
Max H. Stone ◽  
Nicholas Raun ◽  
Shelby L. Rice ◽  
Mohammed Sarikahya ◽  
...  
Keyword(s):  
Intellectual Disability ◽  
Mushroom Body ◽  
Functional Characterization ◽  
Long Term Memory ◽  
Term Memory ◽  
Functional Understanding ◽  
Short And Long Term ◽  
Cellular Components

AbstractTechnology has led to rapid progress in the identification of genes involved in neurodevelopmental disorders like intellectual disability (ID), but our functional understanding of the causative genes is lagging. Here, we show that the SWI/SNF chromatin remodeling complex is one of the most overrepresented cellular components disrupted in ID. We systematically investigated the role of individual subunits of this large protein complex in post-mitotic memory forming neurons of the Drosophila mushroom body (MB). Using this approach, we have identified novel differential roles for the two prominent conformations of the Drosophila SWI/SNF complex, known as BAP and PBAP. The PBAP conformation is required post-mitotically for remodeling of the MB γ neurons during morphogenesis and is essential for both short and long-term memory. In contrast, the BAP conformation appears to preferentially effect long-term memory and is associated with γ neuron survival. Our results suggest that different subunits of the SWI/SNF complex may influence learning and memory through diverse and distinct roles in regulating structural plasticity, survival, and functionality of post-mitotic neurons. This study provides novel insight into the neuronal function of individual SWI/SNF subunits and will serve as a basis for understanding SWI/SNF-mediated gene regulatory mechanisms in post-mitotic neurons.

scholarly journals Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Yanying Wu ◽  
Yosuke Funato ◽  
Eleonora Meschi ◽  
Kristijan D Jovanoski ◽  
Hiroaki Miki ◽  
...  
Keyword(s):  
Mushroom Body ◽  
Vital Role ◽  
Long Term Memory ◽  
Efflux Transporter ◽  
Synaptic Density ◽  
Term Memory ◽  
Kenyon Cells ◽  
Dietary Magnesium ◽  
Elevated Expression

Dietary magnesium (Mg2+) supplementation can enhance memory in young and aged rats. Memory-enhancing capacity was largely ascribed to increases in hippocampal synaptic density and elevated expression of the NR2B subunit of the NMDA-type glutamate receptor. Here we show that Mg2+ feeding also enhances long-term memory in Drosophila. Normal and Mg2+-enhanced fly memory appears independent of NMDA receptors in the mushroom body and instead requires expression of a conserved CNNM-type Mg2+-efflux transporter encoded by the unextended (uex) gene. UEX contains a putative cyclic nucleotide-binding homology domain and its mutation separates a vital role for uex from a function in memory. Moreover, UEX localization in mushroom body Kenyon cells (KCs) is altered in memory-defective flies harboring mutations in cAMP-related genes. Functional imaging suggests that UEX-dependent efflux is required for slow rhythmic maintenance of KC Mg2+. We propose that regulated neuronal Mg2+ efflux is critical for normal and Mg2+-enhanced memory.

scholarly journals Long-term memory is formed immediately without the need for protein synthesis-dependent consolidation in Drosophila

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Bohan Zhao ◽  
Jiameng Sun ◽  
Xuchen Zhang ◽  
Han Mo ◽  
Yijun Niu ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Mushroom Body ◽  
Brain Regions ◽  
Long Term Memory ◽  
Single Trial ◽  
Olfactory Conditioning ◽  
Consolidation Process ◽  
Independent Manner ◽  
Term Memory

Abstract It is believed that long-term memory (LTM) cannot be formed immediately because it must go through a protein synthesis-dependent consolidation process. However, the current study uses Drosophila aversive olfactory conditioning to show that such processes are dispensable for context-dependent LTM (cLTM). Single-trial conditioning yields cLTM that is formed immediately in a protein-synthesis independent manner and is sustained over 14 days without decay. Unlike retrieval of traditional LTM, which requires only the conditioned odour and is mediated by mushroom-body neurons, cLTM recall requires both the conditioned odour and reinstatement of the training-environmental context. It is mediated through lateral-horn neurons that connect to multiple sensory brain regions. The cLTM cannot be retrieved if synaptic transmission from any one of these centres is blocked, with effects similar to those of altered encoding context during retrieval. The present study provides strong evidence that long-term memory can be formed easily without the need for consolidation.

scholarly journals A Permissive Role of Mushroom Body α/β Core Neurons in Long-Term Memory Consolidation in Drosophila

2012 ◽  
Vol 22 (21) ◽  
pp. 1981-1989 ◽  
Author(s):  
Cheng Huang ◽  
Xingguo Zheng ◽  
Hong Zhao ◽  
Min Li ◽  
Pengzhi Wang ◽  
...  
Keyword(s):  
Memory Consolidation ◽  
Mushroom Body ◽  
Long Term Memory ◽  
Term Memory ◽  
Permissive Role

scholarly journals Increased abundance of nuclear HDAC4 impairs neuronal development and long-term memory

2021 ◽  
Author(s):  
Patrick Main ◽  
Wei Jun Tan ◽  
David Wheeler ◽  
Helen L Fitzsimons
Keyword(s):  
Subcellular Distribution ◽  
Mushroom Body ◽  
Neuronal Development ◽  
Eye Development ◽  
Critical Role ◽  
Long Term Memory ◽  
Term Memory ◽  
Neuronal Nuclei ◽  
Transcriptional Changes

AbstractDysregulation of the histone deacetylase HDAC4 is associated with both neurodevelopmental and neurodegenerative disorders, and a feature common to many of these disorders is impaired cognitive function. HDAC4 shuttles between the nucleus and cytoplasm in both vertebrates and invertebrates and alterations in the amounts of nuclear and/or cytoplasmic HDAC4 have been implicated in these diseases. In Drosophila, HDAC4 also plays a critical role in the regulation of memory however the mechanisms through which it acts are unknown. Nuclear and cytoplasmically-restricted HDAC4 mutants were expressed in the Drosophila brain to investigate a mechanistic link between HDAC4 subcellular distribution, transcriptional changes and neuronal dysfunction. Deficits in mushroom body morphogenesis, eye development and long-term memory correlated with increased abundance of nuclear HDAC4 but were associated with minimal transcriptional changes. Although HDAC4 sequesters MEF2 into punctate foci within neuronal nuclei, no alteration in MEF2 activity was observed on overexpression of HDAC4, and knockdown of MEF2 had no impact on long-term memory, indicating that HDAC4 is likely not acting through MEF2. Similarly, deletion of the MEF2 binding site also had no impact on HDAC4-induced impairments in eye development, however it did significantly reduce the mushroom body deficits, thus nuclear HDAC4 acts through MEF2 to disrupt mushroom body development. These data provide insight into the mechanisms through which dysregulation of HDAC4 subcellular distribution impairs neurological function and provides new avenues for further investigation.

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