scholarly journals High-resolution fluorescence-guided transcranial ultrasound mapping in the live mouse brain

2021 ◽  
Vol 7 (50) ◽  
Author(s):  
Hector Estrada ◽  
Justine Robin ◽  
Ali Özbek ◽  
Zhenyue Chen ◽  
Anne Marowsky ◽  
...  
Keyword(s):  
High Resolution ◽  
Mouse Brain ◽  
Transcranial Ultrasound ◽  
Live Mouse

scholarly journals Deep Learning-powered Bessel-beam Multi-parametric Photoacoustic Microscopy

2021 ◽  
Author(s):  
Yifeng Zhou ◽  
Naidi Sun ◽  
Song Hu
Keyword(s):  
Deep Learning ◽  
High Resolution ◽  
Gaussian Beam ◽  
Mouse Brain ◽  
Bessel Beam ◽  
Large Field ◽  
Depth Range ◽  
Photoacoustic Microscopy ◽  
Beam Excitation ◽  
Live Mouse

Enabling simultaneous and high resolution quantification of the total concentration of hemoglobin (CHb), oxygen saturation of hemoglobin (sO2), and cerebral blood flow (CBF), multi parametric photoacoustic microscopy (PAM) has emerged as a promising tool for functional and metabolic imaging of the live mouse brain. However, due to the limited depth of focus imposed by the Gaussian beam excitation, the quantitative measurements become inaccurate when the imaging object is out of focus. To address this problem, we have developed a hardware-software combined approach by integrating Bessel beam excitation and conditional generative adversarial network (cGAN) based deep learning. Side by side comparison of the new cGAN powered Bessel-beam multi parametric PAM against the conventional Gaussian beam multi parametric PAM shows that the new system enables high resolution, quantitative imaging of CHb, sO2, and CBF over a depth range of ~600 μm in the live mouse brain, with errors 13 to 58 times lower than those of the conventional system. Better fulfilling the rigid requirement of light focusing for accurate hemodynamic measurements, the deep learning powered Bessel beam multi parametric PAM may find applications in large field functional recording across the uneven brain surface and beyond (e.g., tumor imaging).

scholarly journals High-resolution dynamic oxygen-17 MR imaging of mouse brain with golden-ratio-based radial sampling and k-space-weighted image reconstruction

2017 ◽  
Vol 79 (1) ◽  
pp. 256-263 ◽  
Author(s):  
Yuchi Liu ◽  
Yifan Zhang ◽  
Chunying Wu ◽  
Junqing Zhu ◽  
Charlie Wang ◽  
...  
Keyword(s):  
High Resolution ◽  
Image Reconstruction ◽  
Mr Imaging ◽  
Mouse Brain ◽  
Golden Ratio ◽  
Weighted Image ◽  
Radial Sampling

High-Resolution Fiber and Fiber Tract Imaging Using Polarized Light Microscopy in the Human, Monkey, Rat, and Mouse Brain

2016 ◽  
pp. 369-389 ◽  
Author(s):  
Karl Zilles ◽  
Nicola Palomero-Gallagher ◽  
David Gräßel ◽  
Philipp Schlömer ◽  
Markus Cremer ◽  
...  
Keyword(s):  
High Resolution ◽  
Light Microscopy ◽  
Mouse Brain ◽  
Polarized Light ◽  
Polarized Light Microscopy ◽  
Fiber Tract

Chronic imaging of amyloid plaques in the live mouse brain using multiphoton microscopy

2001 ◽  
Author(s):  
Brian J. Bacskai ◽  
Stephen T. Kajdasz ◽  
R. H. Christie ◽  
Warren R. Zipfel ◽  
Rebecca M. Williams ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Multiphoton Microscopy ◽  
Amyloid Plaques ◽  
Live Mouse

scholarly journals Transcranial magnetic stimulation of mouse brain using high-resolution anatomical models

2014 ◽  
Vol 115 (17) ◽  
pp. 17B303 ◽  
Author(s):  
L. J. Crowther ◽  
R. L. Hadimani ◽  
A. G. Kanthasamy ◽  
D. C. Jiles
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
High Resolution ◽  
Mouse Brain ◽  
Magnetic Stimulation ◽  
Anatomical Models ◽  
Stimulation Of

scholarly journals High-Resolution Analysis of Parent-of-Origin Allelic Expression in the Mouse Brain

Science ◽  
2010 ◽  
Vol 329 (5992) ◽  
pp. 643-648 ◽  
Author(s):  
C. Gregg ◽  
J. Zhang ◽  
B. Weissbourd ◽  
S. Luo ◽  
G. P. Schroth ◽  
...  
Keyword(s):  
High Resolution ◽  
Mouse Brain ◽  
Allelic Expression ◽  
High Resolution Analysis ◽  
Resolution Analysis ◽  
Parent Of Origin
Sign in / Sign up

Export Citation Format

Share Document