scholarly journals Antibodies to the conserved region of the M protein and a streptococcal superantigen cooperatively resolve toxic shock-like syndrome in HLA-humanized mice

2019 ◽  
Vol 5 (9) ◽  
pp. eaax3013 ◽  
Author(s):  
Manisha Pandey ◽  
Ainslie Calcutt ◽  
Victoria Ozberk ◽  
Zhenjun Chen ◽  
Matthew Croxen ◽  
...  
Keyword(s):  
Streptococcus Pyogenes ◽  
Toxic Shock Syndrome ◽  
Strong Support ◽  
M Protein ◽  
Bacterial Burden ◽  
Toxic Shock ◽  
Passive Immunotherapy ◽  
Streptococcal Disease ◽  
Streptococcal M Protein ◽  
Established Disease

Invasive streptococcal disease (ISD) and toxic shock syndrome (STSS) result in over 160,000 deaths each year. We modelled these in HLA-transgenic mice infected with a clinically lethal isolate expressing Streptococcal pyrogenic exotoxin (Spe) C and demonstrate that both SpeC and streptococcal M protein, acting cooperatively, are required for disease. Vaccination with a conserved M protein peptide, J8, protects against STSS by causing a dramatic reduction in bacterial burden associated with the absence of SpeC and inflammatory cytokines in the blood. Furthermore, passive immunotherapy with antibodies to J8 quickly resolves established disease by clearing the infection and ablating the inflammatory activity of the M protein, which is further enhanced by addition of SpeC antibodies. Analysis of 77 recent isolates of Streptococcus pyogenes causing ISD, demonstrated that anti-J8 antibodies theoretically recognize at least 73, providing strong support for using antibodies to J8, with or without antibodies to SpeC, as a therapeutic approach.

scholarly journals Spontaneous mutations in Streptococcus pyogenes isolates from streptococcal toxic shock syndrome patients play roles in virulence

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Tadayoshi Ikebe ◽  
Takayuki Matsumura ◽  
Hisako Nihonmatsu ◽  
Hitomi Ohya ◽  
Rumi Okuno ◽  
...  
Keyword(s):  
Streptococcus Pyogenes ◽  
Toxic Shock Syndrome ◽  
Streptococcal Toxic Shock Syndrome ◽  
Spontaneous Mutations ◽  
Toxic Shock

scholarly journals Gastrointestinal Mucormycosis following aStreptococcus pyogenesToxic Shock Syndrome in a Previously Healthy Patient: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Jean-François Roussy ◽  
Catherine Allard ◽  
Guy St-Germain ◽  
Jacques Pépin
Keyword(s):  
Case Report ◽  
Opportunistic Infection ◽  
Streptococcus Pyogenes ◽  
Toxic Shock Syndrome ◽  
Immunocompromised Patients ◽  
Healthy Patient ◽  
Toxic Shock ◽  
Rhizopus Microsporus ◽  
First Case ◽  
Rhizopus Sp

Mucormycosis is an uncommon opportunistic infection and the gastrointestinal form is the rarest.Rhizopus sp. is the most frequent pathogen and infection occurs almost exclusively in immunocompromised patients. We describe the first case of intestinal mucormycosis occurring after aStreptococcus pyogenestoxic shock syndrome in a previously healthy patient caused byRhizopus microsporusvar.azygosporus.

Fulminant infection and toxic shock syndrome caused by Streptococcus pyogenes

2002 ◽  
Vol 22 (4) ◽  
pp. 357-366 ◽  
Author(s):  
Kevin L Fox ◽  
Michael W Born ◽  
Merrill A Cohen
Keyword(s):  
Streptococcus Pyogenes ◽  
Toxic Shock Syndrome ◽  
Toxic Shock

scholarly journals Pemanfaatan Buah Belimbing Wuluh (Averrhoa bilimbi L.) Sebagai Alternatif Penanganan Toxic Shock Syndrome

2020 ◽  
pp. 73 ◽  
Author(s):  
Suly Sunarsi
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pyogenes ◽  
Toxic Shock Syndrome ◽  
Stevia Rebaudiana ◽  
Toxic Shock

Toxic Shock Syndrome (TSS) merupakan penyakit akut yang mengancam jiwa yang dimediasi oleh racun, biasanya dipicu oleh infeksi Staphylococcus aureus atau grup A Streptococcus (GAS), diantaranya Streptococcus pyogenes. Pemanfaatan buah belimbing wuluh masih terbatas dibandingkan dengan ketersediannya di kalangan masyarakat, sehingga penelitian ini bermaksud untuk memanfaatkan belimbing wuluh yang diformulasi dalam bentuk Infused Water dengan pemanis alami Stevia rebaudiana yang digunakan sebagai alternatif penanganan Toxic Shock Syndrome dengan penghambatan pada bakteri Streptococcus pyogenes. Sari buah belimbing wuluh dan liofilisatnya diujikan terhadap Streptococcus pyogenes secara In Vitro dengan beberapa variasi konsentrasi untuk melihat aktivitas antibakterinya. Infused water buah belimbing wuluh dibuat dengan metode perendaman selama 12 jam dan 24 jam dengan kombinasi 500 mg daun stevia dalam 250 mL air matang dan dievaluasi menggunakan uji organoleptik, uji ALT dan uji MPN. Hasil penelitian menunjukkan uji aktivitas antibakteri sari buah belimbing wuluh terdapat zona hambat dengan diameter 7,09±0,2 (1%), 7,41±0,1 (3%), 8,33±0,3 (5%), dan 8,38±0,2 (10%). Sedangkan liofilisat sari buah belimbing wuluh menunjukkan zona hambat dengan diameter 7,11±0,4 (1%), 7,34±0,3 (3%), 7,05±0,8 (5%), dan 7,44±0,9 (10%).

scholarly journals Streptococcal toxic shock syndrome caused by the dissemination of an invasive emm3/ST15 strain of Streptococcus pyogenes

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Tsuyoshi Sekizuka ◽  
Emina Nai ◽  
Tomohiro Yoshida ◽  
Shota Endo ◽  
Emi Hamajima ◽  
...  
Keyword(s):  
Streptococcus Pyogenes ◽  
Toxic Shock Syndrome ◽  
Streptococcal Toxic Shock Syndrome ◽  
Toxic Shock

Streptococcal toxic shock syndrome by an iMLS resistant M type 77 Streptococcus pyogenes in the Netherlands

2005 ◽  
Vol 37 (2) ◽  
pp. 85-89 ◽  
Author(s):  
J. Gooskens ◽  
A. J. De Neeling ◽  
R. J. Willems ◽  
J. W. Van 'T Wout ◽  
E. J. Kuijper
Keyword(s):  
The Netherlands ◽  
Streptococcus Pyogenes ◽  
Toxic Shock Syndrome ◽  
Streptococcal Toxic Shock Syndrome ◽  
Toxic Shock

Toxic Shock Syndrome Due to Streptococcus pyogenes: Postmortem Case Report

2015 ◽  
Vol 12 (1) ◽  
pp. 28-32
Author(s):  
Nihan ZİYADE ◽  
Ceyhun KÜÇÜK ◽  
Taner DAŞ ◽  
Süleyman YILMAZ ◽  
Nagehan PAKAŞTİÇALI ◽  
...  
Keyword(s):  
Case Report ◽  
Streptococcus Pyogenes ◽  
Toxic Shock Syndrome ◽  
Toxic Shock

scholarly journals Toxic shock syndrome (TSS)

2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Johan Arifin
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pyogenes ◽  
Toxic Shock Syndrome ◽  
Toxic Shock

Toxic shock syndrome (TSS) adalah penyakit akut yang mengancam jiwa yang dimediasi oleh racun, biasanya dipicu oleh infeksi Staphylococcus aureus atau grup A Streptococcus (GAS), yang juga disebut Streptococcus pyogenes. Hal ini ditandai dengan demam tinggi, ruam, hipotensi, kegagalan multiorgan (melibatkan setidaknya 3 atau lebih sistem organ), dan deskuamasi, biasanya dari telapak tangan dan telapak kaki, 1-2 minggu setelah onset penyakit akut. Sindrom klinis juga dapat mencakup mialgia berat, muntah, diare, sakit kepala, dan kelainan neurologis nonfocal

scholarly journals Streptococcus pyogenes as a cause of toxic shock syndrome

2017 ◽  
Vol 18 (1) ◽  
pp. 59-63
Author(s):  
Radka Drápalová ◽  
František Kopřiva ◽  
Lenka Šigutová ◽  
Vratislav Smolka ◽  
Kamila Michálková ◽  
...  
Keyword(s):  
Streptococcus Pyogenes ◽  
Toxic Shock Syndrome ◽  
Toxic Shock
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