scholarly journals Repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth

2019 ◽  
Vol 5 (8) ◽  
pp. eaaw9569 ◽  
Author(s):  
Changyu Shao ◽  
Biao Jin ◽  
Zhao Mu ◽  
Hao Lu ◽  
Yueqi Zhao ◽  
...  
Keyword(s):  
Epitaxial Growth ◽  
Tooth Enamel ◽  
Apatite Structure ◽  
Biomimetic Mineralization ◽  
Hard Tissue ◽  
Complicated Structure ◽  
Ion Clusters ◽  
Phosphate Ion ◽  
Promising Strategy ◽  
Epitaxial Crystal Growth

The regeneration of tooth enamel, the hardest biological tissue, remains a considerable challenge because its complicated and well-aligned apatite structure has not been duplicated artificially. We herein reveal that a rationally designed material composed of calcium phosphate ion clusters can be used to produce a precursor layer to induce the epitaxial crystal growth of enamel apatite, which mimics the biomineralization crystalline-amorphous frontier of hard tissue development in nature. After repair, the damaged enamel can be recovered completely because its hierarchical structure and mechanical properties are identical to those of natural enamel. The suggested phase transformation–based epitaxial growth follows a promising strategy for enamel regeneration and, more generally, for biomimetic reproduction of materials with complicated structure.

scholarly journals Effect of packaged strawberry juice on the surface roughness of nanofilled type composite resin

2013 ◽  
Vol 25 (3) ◽  
Author(s):  
Rizky Amelia ◽  
Opik Taofik Hidayat ◽  
Denny Nurdin
Keyword(s):  
Acid Treatment ◽  
Composite Resin ◽  
Tooth Enamel ◽  
Heat Exposure ◽  
Strong Acid ◽  
Microscopic Structure ◽  
Hard Tissue ◽  
Micro Cracks ◽  
The Subject ◽  
Type Composite

Introduction: The hard tissue of the teeth is resistant to heat and acid,  so that the teeth have an important role as a material consideration of forensic dentistry. The humans have the same shape of the teeth around one in two billion. The stimuli of burn with high temperature and sour can be change the picture of macroscopic and microscopic tooth. This is the subject of an interesting comparison in the interests of justice and identification of dentistry. Methods: This research was a quasi experiment to know a change of microscopic teeth on the hard cases tooth-burning and the case hard acid treatment. The sample used were seven teeth, with details of one normal as a comparison, three teeth burned and three teeth soaked in a solution of water of accu. Observations were made using the microscope at 40x enlarged on each tooth. The tooth was documented by means of a photographed and compared with healthy teeth. Results: The results of this study was obtained by observing and comparing the microscopic structure and the obtained differences in the teeth and treated with the picture of normal teeth. Conclusion: Conclusion of this research is on the tooth are burned was visible loss of enamel at the cement-enamel junction as a result of the process of carbonization heat exposure so as to cause a breach of micro on the outer layer of the tooth enamel and thinning of dentin tubules, while the teeth are in the soak water accu (strong acid) seen change in color of enamel, micro cracks due to defective enamel and depletion of tubulus dentine and loss of boundary between the cementum and dentine.

Protein/peptide-templated biomimetic synthesis of inorganic nanoparticles for biomedical applications

2017 ◽  
Vol 5 (3) ◽  
pp. 401-417 ◽  
Author(s):  
Weitao Yang ◽  
Weisheng Guo ◽  
Jin Chang ◽  
Bingbo Zhang
Keyword(s):  
Metal Nanoparticles ◽  
Biomedical Applications ◽  
Inorganic Nanoparticles ◽  
Biomimetic Synthesis ◽  
Biomimetic Mineralization ◽  
Promising Strategy

Currently, protein/peptide-based biomimetic mineralization has been demonstrated to be an efficient and promising strategy for synthesis of inorganic/metal nanoparticles (NPs) for bioapplications.

Early Nucleation Events in the Biomineralization of Calcium Phosphates

2011 ◽  
Vol 1301 ◽  
Author(s):  
Baoquan Xie ◽  
George Nancollas
Keyword(s):  
Calcium Phosphates ◽  
Crystal Nucleation ◽  
Supersaturated Solution ◽  
Major Step ◽  
Ion Clusters ◽  
Phosphate Ion ◽  
Combined Use ◽  
O Phase

ABSTRACTOur work focuses on the earliest events of homo-/heterogeneous nucleation from an initial supersaturated solution to the subsequent growth of nuclei. The combined use of conductance, together with hydrogen and calcium ISEs has provided new insights into the mechanisms of crystal nucleation and phase stability. We propose that two types of ACP are formed during HAP nucleation. The initial subcritical calcium-phosphate ion clusters form an amorphous [CaHPO4·xH2O] phase (ACP-1), which transforms to amorphous [Ca3(PO4)2] (ACP-2), and subsequently to HAP. This study is a major step forward in our understanding of the earliest nucleation events in vitro and in vivo. Additives may influence HAP nucleation by interacting with ACP clusters during the early induction period.

From Biomimetic Mineralization to Carbonization: Fabricating Heterostructured Porous Carbon Materials with MOF Encapsulated Bacteria

2019 ◽  
Author(s):  
Shaobo Li ◽  
Xiaoshuang Zhou ◽  
Zhuo Chen ◽  
Rangana Jayawickramage ◽  
Sampath B. Alahakoon ◽  
...  
Keyword(s):  
Carbon Materials ◽  
Growth Efficiency ◽  
Great Promise ◽  
Porous Structures ◽  
Biomimetic Mineralization ◽  
Promising Strategy ◽  
Electrochemical Capacity ◽  
Metal Organic ◽  
Encapsulated Bacteria ◽  
New Generation

ABSTRACT:Hierarchical porous carbons (HPCs) hold great promise in energy-related applications owing to their excellent chemical stability and well-developed porous structures. Attention has been drawn toward developing new synthetic strategies and precursor materials that permit greater control over composition, size, morphology, and pore structure. There is a growing trend of employing metal-organic frameworks (MOFs) as HPC precursors as their highly customizable characteristics favor new HPC syntheses. In this article, we report a biomimetically grown bacteria-templated MOF synthesis where the bacteria not only facilitates the formation of MOF nanocrystals, but also provides morphology and porosity control. The resultant HPCs show improved electrochemical capacity behavior compared to pristine MOF derived HPCs. Considering the broad availability of bacteria and ease of its production, in addition to significantly improved MOF growth efficiency on bacterial templates, we believe that bacteria-templated MOF is a promising strategy to produce a new generation of HPCs.

Progress on Biomimetic Mineralization and Materials for Hard Tissue Regeneration

2021 ◽  
Author(s):  
Jie Wang ◽  
Qiqi Liu ◽  
Zhengxi Guo ◽  
Haihua Pan ◽  
Zhaoming Liu ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Biomimetic Mineralization ◽  
Hard Tissue

scholarly journals Microscopic appearance of healthy teeth, burned-tooth and automobile battery solution soaked tooth for the importance of visum in forensic dentistry

2013 ◽  
Vol 25 (3) ◽  
Author(s):  
Randy Rozano ◽  
Murnisari Dardjan ◽  
Fahmi Oscandar
Keyword(s):  
Tooth Enamel ◽  
Heat Exposure ◽  
Strong Acid ◽  
Microscopic Structure ◽  
Forensic Dentistry ◽  
Hard Tissue ◽  
Microscopic Appearance ◽  
Micro Cracks ◽  
The Subject ◽  
Dentin Tubules

Introduction: The hard tissue of the teeth is resistant to heat and acid,  so that the teeth have an important role as a material consideration of forensic dentistry. The humans have the same shape of the teeth around one in two billion. The stimuli of burn with high temperature and sour can be change the picture of macroscopic and microscopic tooth. This is the subject of an interesting comparison in the interests of justice and identification of dentistry. Methods: This research was a quasi experiment to analyzed change of microscopic teeth on the hard cases tooth-burning and the case hard acid treatment.The sample used were seven teeth, with details of one normal as a comparison, three teeth burned and three teeth soaked in a solution of water of accu.. Observations were made using the microscope at 40x enlarged on each tooth. The tooth was documented by means of a photographed and compared with healthy teeth. Observing and comparing the microscopic structure and the obtained differences in the teeth and treated with the picture of normal teeth. Results: The results of this study was obtained by observing and comparing the microscopic structure and the obtaineddifferences in the teeth and treated with the picture of normal teeth. Conclusion: The tooth are burned was visible loss of enamel at the cement-enamel junction as a result of the process of carbonization heat exposure so as to cause a breach of micro on the outer layer of the tooth enamel and thinning of dentin tubules, while the teeth are in the soak water accu (strong acid) seen change in color of enamel, micro cracks due to defective enamel and depletion of tubulus dentine and loss of boundary between the cementum and dentine.

scholarly journals From Biomimetic Mineralization to Carbonization: Fabricating Heterostructured Porous Carbon Materials with MOF Encapsulated Bacteria

2019 ◽  
Author(s):  
Shaobo Li ◽  
Ziaoshuang Zhou ◽  
Zhuo Chen ◽  
Rangana Jayawickramage ◽  
Sampath B. Alahakoon ◽  
...  
Keyword(s):  
Carbon Materials ◽  
Growth Efficiency ◽  
Great Promise ◽  
Porous Structures ◽  
Biomimetic Mineralization ◽  
Promising Strategy ◽  
Electrochemical Capacity ◽  
Metal Organic ◽  
Encapsulated Bacteria ◽  
New Generation

ABSTRACT:Hierarchical porous carbons (HPCs) hold great promise in energy-related applications owing to their excellent chemical stability and well-developed porous structures. Attention has been drawn toward developing new synthetic strategies and precursor materials that permit greater control over composition, size, morphology, and pore structure. There is a growing trend of employing metal-organic frameworks (MOFs) as HPC precursors as their highly customizable characteristics favor new HPC syntheses. In this article, we report a biomimetically grown bacteria-templated MOF synthesis where the bacteria not only facilitates the formation of MOF nanocrystals, but also provides morphology and porosity control. The resultant HPCs show improved electrochemical capacity behavior compared to pristine MOF derived HPCs. Considering the broad availability of bacteria and ease of its production, in addition to significantly improved MOF growth efficiency on bacterial templates, we believe that bacteria-templated MOF is a promising strategy to produce a new generation of HPCs.

scholarly journals Cell-Free Biomimetic Mineralization Strategies to Regenerate the Enamel Microstructure

Crystals ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1385
Author(s):  
Yu Yuan Zhang ◽  
Quan Li Li ◽  
Hai Ming Wong
Keyword(s):  
Physical Mechanism ◽  
Great Promise ◽  
Biomimetic Mineralization ◽  
Hard Tissue ◽  
Enamel Microstructure ◽  
Physical Difference ◽  
Invasive Strategy ◽  
Non Invasive ◽  
Fracture Toughening ◽  
Invasive Method

The distinct architecture of native enamel gives it its exquisite appearance and excellent intrinsic-extrinsic fracture toughening properties. However, damage to the enamel is irreversible. At present, the clinical treatment for enamel lesion is an invasive method; besides, its limitations, caused by the chemical and physical difference between restorative materials and dental hard tissue, makes the restorative effects far from ideal. With more investigations on the mechanism of amelogenesis, biomimetic mineralization techniques for enamel regeneration have been well developed, which hold great promise as a non-invasive strategy for enamel restoration. This review disclosed the chemical and physical mechanism of amelogenesis; meanwhile, it overviewed and summarized studies involving the regeneration of enamel microstructure in cell-free biomineralization approaches, which could bring new prospects for resolving the challenges in enamel regeneration.

On the Possible Relation between Morphology and Precursors of the Crystallities in Calcified Tissues

1987 ◽  
Vol 42 (7-8) ◽  
pp. 916-920 ◽  
Author(s):  
F.C.M. Driessens ◽  
R.A. Terpstra ◽  
P. Bennema ◽  
J.H.M. Wöltgens ◽  
R.M.H. Verbeeck
Keyword(s):  
Crystal Morphology ◽  
Matrix Effects ◽  
Tooth Enamel ◽  
Apatite Structure ◽  
Mineral Particles ◽  
Precursor Phase ◽  
Main Effect ◽  
The Matrix ◽  
Calcified Tissues ◽  
Precursor Phases

Crystal structure data on hydroxyapatite, octocalcium phosphate and brushite have been used in order to predict their crystal morphology on the basis of the Hartman-Perdok theory. The predicted forms are pencil-like for hydroxyapatite, board-like for octocalcium phosphate and flattened needle-like for brushite. Although the biominerals in bone, dentine and tooth enamel have an apatite structure, their form is nbt pencil-like. This may partially be due to the fact that precursor phases are nucleated first in these tissues during mineralization and that these precursor phases are transformed later by topotactical reactions into compounds with apatite structure or that they serve as nuclei for ongrowth of apatite. The form of the mineral particles in mature bone and dentin is board-like which indicates that octocalcium phosphate might be their precursor phase. However, the form of the crystals in mature enamel is flattened needle-like which indicates that brushite is their precursor phase. It is argued that a possible difference in the nature of the precursor phase may be due primarily to differences in the cellular activities of the odontoblasts and osteoblasts as compared to those of the ameloblasts, and secondarily to matrix effects. In both cases, however, the main effect of the matrix seems to be that it acts as a mechanical barrier leading to a limited form and size and, of course, a certain orientation of the crystals, rather than as an agent for heterogeneous nucleation. The validity of the present considerations depends as yet on the assumption that the ions and molecules occurring in body fluids do not dominate the habit of calcium phosphate crystals.

scholarly journals Effect of Remineralized Collagen on Dentin Bond Strength through Calcium Phosphate Ion Clusters or Metastable Calcium Phosphate Solution

Nanomaterials ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2203
Author(s):  
Hyeryeong Kim ◽  
Aerin Choi ◽  
Mi-Kyung Gong ◽  
Hae Ryoun Park ◽  
Yong-Il Kim
Keyword(s):  
Calcium Phosphate ◽  
Bond Strength ◽  
Tensile Bond Strength ◽  
Phosphate Solution ◽  
Strength Increase ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Ion Clusters ◽  
Phosphate Ion ◽  
Transmission Electron

This study aimed to investigate whether dentin remineralization and micro-tensile bond strength increase when using calcium phosphate ion clusters (CPICs) or metastable Ca-P. After being etched, each dentin specimen was designated into four groups and treated with the appropriate solution for 1 min: 100% ethanol, 2 and 1 mg/mL of CPICs, and metastable Ca-P. The specimens were then prepared for scanning electron microscopy (SEM), transmission electron microscropy (TEM) imaging, a matrix metalloproteinases inhibition assay, and the micro-tensile bond strength test. To compare among the groups, one-way analysis of variance was performed. In the SEM imaging, with a rising concentration of CPICs, the degree of remineralization of dentin increased significantly. The metastable Ca-P treated specimens showed a similar level of remineralization as the 1 mg/mL CPICs treated specimens. The TEM imaging also revealed that dentin remineralization occurs in a CPICs concentration-dependent manner between the demineralized dentin and the resin layer. Furthermore, the results of micro-tensile bond strength showed the same trend as the results confirmed by SEM and TEM. We demonstrated that a 1 min pretreatment of CPICs or metastable Ca-P in etched dentin collagen fibril can achieve biomimetic remineralization and increase micro-tensile bond strength.

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