Protein/peptide-templated biomimetic synthesis of inorganic nanoparticles for biomedical applications

2017 ◽  
Vol 5 (3) ◽  
pp. 401-417 ◽  
Author(s):  
Weitao Yang ◽  
Weisheng Guo ◽  
Jin Chang ◽  
Bingbo Zhang
Keyword(s):  
Metal Nanoparticles ◽  
Biomedical Applications ◽  
Inorganic Nanoparticles ◽  
Biomimetic Synthesis ◽  
Biomimetic Mineralization ◽  
Promising Strategy

Currently, protein/peptide-based biomimetic mineralization has been demonstrated to be an efficient and promising strategy for synthesis of inorganic/metal nanoparticles (NPs) for bioapplications.

scholarly journals Magnetoferritin: Process, Prospects, and Their Biomedical Applications

2019 ◽  
Vol 20 (10) ◽  
pp. 2426 ◽  
Author(s):  
Le Xue ◽  
Dawei Deng ◽  
Jianfei Sun
Keyword(s):  
Catalytic Activity ◽  
Iron Oxide ◽  
Biomedical Applications ◽  
Biomimetic Synthesis ◽  
Iron Core ◽  
Biomimetic Mineralization ◽  
Iron Storage ◽  
Magnetic Nanomaterial ◽  
Good Biocompatibility ◽  
Iron Storage Protein

Ferritin is a spherical iron storage protein composed of 24 subunits and an iron core. Using biomimetic mineralization, magnetic iron oxide can be synthesized in the cavity of ferritin to form magnetoferritin (MFt). MFt, also known as a superparamagnetic protein, is a novel magnetic nanomaterial with good biocompatibility and flexibility for biomedical applications. Recently, it has been demonstrated that MFt had tumor targetability and a peroxidase-like catalytic activity. Thus, MFt, with its many unique properties, provides a powerful platform for tumor diagnosis and therapy. In this review, we discuss the biomimetic synthesis and biomedical applications of MFt.

Review on Methodologies Used in the Synthesis of Metal Nanoparticles: Significance of Phytosynthesis Using Plant Extract as an Emerging Tool

2020 ◽  
Vol 26 (40) ◽  
pp. 5188-5204
Author(s):  
Uzair Nagra ◽  
Maryam Shabbir ◽  
Muhammad Zaman ◽  
Asif Mahmood ◽  
Kashif Barkat
Keyword(s):  
Green Synthesis ◽  
Metal Nanoparticles ◽  
Plant Extracts ◽  
Biomedical Applications ◽  
Noble Metals ◽  
Cost Effective ◽  
Green Technology ◽  
Critical Parameters ◽  
Nanosized Particles ◽  
Preparation Methods

Nanosized particles, with a size of less than 100 nm, have a wide variety of applications in various fields of nanotechnology and biotechnology, especially in the pharmaceutical industry. Metal nanoparticles [MNPs] have been synthesized by different chemical and physical procedures. Still, the biological approach or green synthesis [phytosynthesis] is considered as a preferred method due to eco-friendliness, nontoxicity, and cost-effective production. Various plants and plant extracts have been used for the green synthesis of MNPs, including biofabrication of noble metals, metal oxides, and bimetallic combinations. Biomolecules and metabolites present in plant extracts cause the reduction of metal ions into nanosized particles by one-step preparation methods. MNPs have remarkable attractiveness in biomedical applications for their use as potential antioxidant, anticancer and antibacterial agents. The present review offers a comprehensive aspect of MNPs production via top-to-bottom and bottom-to-top approach with considerable emphasis on green technology and their possible biomedical applications. The critical parameters governing the MNPs formation by plant-based synthesis are also highlighted in this review.

scholarly journals Surface Structuring via Additive Manufacturing to Improve the Performance of Metal and Polymer Joints

Metals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 567
Author(s):  
Xin Zou ◽  
Lifu Huang ◽  
Ke Chen ◽  
Muyang Jiang ◽  
Shanyong Zhang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Electron Beam Melting ◽  
Biomedical Applications ◽  
Surface Structures ◽  
Joint Performance ◽  
Ti6al4v Titanium Alloy ◽  
Promising Strategy ◽  
Surface Structuring ◽  
Ultra High Molecular Weight ◽  
Metal Polymer

In order to enhance the joint performance of Ti6Al4V titanium alloy (TC4) and ultra-high molecular weight polyethylene (UHMWPE) for biomedical applications, different structures were fabricated on TC4 surfaces via electron beam melting (EBM) method in this study. Macromorphologies and microinterfaces of TC4–UHMWPE joints produced via hot pressing technique were carefully characterized and analyzed. The effects of different surface structures on mechanical properties and fractured surfaces were investigated and compared. Strong direct bonding (1751 N) between UHMWPE and TC4 was achieved. The interfacial bonding behavior of TC4–UHMWPE joints was further discussed. This study demonstrates the importance of combining macro- and micromechanical interlocking, which is a promising strategy for improving metal–polymer joint performance. It also provides guidance for metal surface structuring from both theoretical and practical perspectives.

scholarly journals (Intra)Cellular Stability of Inorganic Nanoparticles: Effects on Cytotoxicity, Particle Functionality, and Biomedical Applications

2015 ◽  
Vol 115 (5) ◽  
pp. 2109-2135 ◽  
Author(s):  
Stefaan J. Soenen ◽  
Wolfgang J. Parak ◽  
Joanna Rejman ◽  
Bella Manshian
Keyword(s):  
Biomedical Applications ◽  
Inorganic Nanoparticles

Hyperthermic Cytotoxicity Induced by Noninvasive Radiofrequency Field Exposure After Delivery of EGFR Family Targeted Gold Nanoparticles

2010 ◽  
Author(s):  
Evan S. Glazer ◽  
Warna D. Kaluarachchi ◽  
Steven A. Curley
Keyword(s):  
Flow Cytometry ◽  
Gold Nanoparticles ◽  
Metal Nanoparticles ◽  
Biomedical Applications ◽  
Carcinoma Cells ◽  
Field Exposure ◽  
Radiofrequency Field ◽  
Hep3b Cells ◽  
Egfr Family ◽  
Similar Decrease

Noninvasive radiofrequency (RF) fields heat metal nanoparticles in a concentration dependent fashion. Gold nanoparticles are especially interesting for biomedical applications because they not only heat well, but they have an established biosafety profile. Antibody-targeted gold nanoparticles have been used to induce hyperthermic cytotoxicity when exposed to RF fields. Two carcinoma cells lines, Panc-1 and Hep3B, were individually treated with 100 nM panitumumab and trastuzumab antibody conjugated 10 nm gold nanoparticles and subsequently exposed to an RF field for a total generator power of ∼100 kJ. Two days later, control cells treated with antibody labeled gold nanoparticles, but not exposed to the RF field, maintained an average viability of 92.1% ± 2.5% for Hep 3B cells and 89.1% ± 2.1% for Panc-1 cells based on flow cytometry. Panc-1 cells treated the same way with subsequent RF field exposure had viability less than 80% (p ∼ 0.001). Hep3B cells showed a similar decrease in viability after trastuzumab-gold treatment (74.5% ± 6.9%), but not panitumumab. This demonstrates a new and developing use of antibodies, specifically, against EGFR family targets.

scholarly journals Inorganic Nanoparticles: Toxic Effects, Mechanisms of Cytotoxicity and Phytochemical Interactions

2021 ◽  
Author(s):  
Rashid Bhatti ◽  
Hadia Shakeel ◽  
Kousar Malik ◽  
Muhammad Qasim ◽  
Mohsin Ahmad Khan ◽  
...  
Keyword(s):  
Metal Nanoparticles ◽  
Human Health ◽  
Reducing Agents ◽  
Inorganic Nanoparticles ◽  
Therapeutic Effects ◽  
Toxicological Effects ◽  
Prime Concern ◽  
Parkinson’S Diseases ◽  
Almost All ◽  
Nanoparticles Toxicity

During the last few decades, nanotechnology has gained many applications in almost all fields of life because of the unique properties of nanoparticles. Nanotechnology has specially marked its name in the field of medicine. However, nanoparticles toxicity is detrimental to human health and is a prime concern in applied medicine. They can cause insomnia, vertigo, madarosis, epistaxis, hypokalemia, lymphopenia, Alzheimer's and Parkinson's diseases, etc. There is a gap in knowledge regarding the study of the toxicological effects of nanoparticles. Mechanisms that are responsible for this toxicity are not fully understood yet. Phytochemicals have natural therapeutic effects of reducing metal nanoparticles' toxicity by acting as stabilizers and nontoxic reducing agents. However, the interaction between phytochemicals and nanoparticles is remained to be elucidated. This review will provide in-depth knowledge about the various types of inorganic nanoparticles and their associated toxicities, key parameters determining the toxic behaviour of nanoparticles, and the mechanisms behind their cytotoxicity. It also emphasizes the need for further research to understand the interaction between various phytochemicals and nanoparticles for therapeutic purposes.

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