scholarly journals Real-time tracking of fluorescent magnetic spore–based microrobots for remote detection of C. diff toxins

2019 ◽  
Vol 5 (1) ◽  
pp. eaau9650 ◽  
Author(s):  
Yabin Zhang ◽  
Lin Zhang ◽  
Lidong Yang ◽  
Chi Ian Vong ◽  
Kai Fung Chan ◽  
...  

A rapid, direct, and low-cost method for detecting bacterial toxins associated with common gastrointestinal diseases remains a great challenge despite numerous studies and clinical assays. Motion-based detection through tracking the emerging micro- and nanorobots has shown great potential in chemo- and biosensing due to accelerated “chemistry on the move”. Here, we described the use of fluorescent magnetic spore–based microrobots (FMSMs) as a highly efficient mobile sensing platform for the detection of toxins secreted by Clostridium difficile (C. diff) that were present in patients’ stool. These microrobots were synthesized rapidly and inexpensively by the direct deposition of magnetic nanoparticles and the subsequent encapsulation of sensing probes on the porous natural spores. Because of the cooperation effect of natural spore, magnetic Fe3O4 nanoparticles, and functionalized carbon nanodots, selective fluorescence detection of the prepared FMSMs is demonstrated in C. diff bacterial supernatant and even in actual clinical stool samples from infectious patients within tens of minutes, suggesting rapid response and good selectivity and sensitivity of FMSMs toward C. diff toxins.

Sensors ◽  
2018 ◽  
Vol 18 (10) ◽  
pp. 3440 ◽  
Author(s):  
Daniela Sousa ◽  
Miguel Luís ◽  
Susana Sargento ◽  
Artur Pereira

The Smart City concept is starting to extend into maritime environments alongside with the increase of Unmanned Surface Vehicles (USV) models on the market. Consequently, by joining both Smart City and USV technologies, a set of platforms and applications for aquatic environments are emerging. This work proposes a low-cost aquatic mobile sensing platform for data gathering with a swarm of USVs communicating through a Delay-Tolerant Network (DTN). A set of DTN link quality-based routing strategies select the best quality path in a dynamic approach so the sensed information is able to reach the mobile gateway in a reliable way. A Link Quality Estimation (LQE) approach is proposed and its accuracy is evaluated through real experimentation. An aquatic simulation environment, considering both navigation and communication layers, was also proposed and used to evaluate the performance of the proposed routing strategies, and complement real environment performance studies.


2015 ◽  
Vol 119 (1) ◽  
pp. 153-164 ◽  
Author(s):  
Lei Tao ◽  
Kang Sun ◽  
David J. Miller ◽  
Dan Pan ◽  
Levi M. Golston ◽  
...  

Author(s):  
Zhengping Feng ◽  
Guiyang Shang ◽  
Lian Lian
Keyword(s):  
Low Cost ◽  

2021 ◽  
Vol 13 (39) ◽  
pp. 4662-4673
Author(s):  
Lulu Xu ◽  
Ruimei Wu ◽  
Xiaoyu Zhu ◽  
Xiaoqiang Wang ◽  
Xiang Geng ◽  
...  

A simple intelligent electrochemical sensing platform based on a low-cost disposable laser-induced porous graphene flexible electrode for maleic hydrazide coupled with machine learning was successfully designed.


2020 ◽  
Vol 10 (11) ◽  
pp. 3730 ◽  
Author(s):  
Josep M. Maso ◽  
Jordi Male ◽  
Joaquim Porte ◽  
Joan L. Pijoan ◽  
David Badia

Every year more interest is focused on high frequencies (HF) communications for remote sensing platforms due to their capacity to establish links of more than 250 km without a line of sight and due to them being a low-cost alternative to satellite communications. In this article, we study the ionospheric ordinary and extraordinary waves to improve the applications of near vertical incidence skywave (NVIS) on a single input multiple output (SIMO) configuration. To obtain the results, we established a link of 95 km to test the diversity combining of ordinary and extraordinary waves by using selection combining (SC) and equal-gain combining (EGC) on a remote sensing platform. The testbench is based on digital modulation transmissions with power transmission between 3 and 100 W. The results show us the main energy per bit to noise spectral density ratio (Eb/N0) and the bit error rate (BER) differences between ordinary and extraordinary waves, SC, and EGC. To conclude, diversity techniques show us a decrease of the power transmission need, allowing for the use of compact antennas and increasing battery autonomy. Furthermore, we present three different improvement options for NVIS SIMO remote sensing platforms depending on the requirements of bitrate, power consumption, and efficiency of communication.


2019 ◽  
Vol 11 (33) ◽  
pp. 29549-29556 ◽  
Author(s):  
Hao Kong ◽  
Wei-wen Liu ◽  
Wei Zhang ◽  
Qiang Zhang ◽  
Cun-huai Wang ◽  
...  

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