Calmodulin-Regulated Adenylyl Cyclases: Cross-Talk and Plasticity in the Central Nervous System

2003 ◽  
Vol 63 (3) ◽  
pp. 463-468 ◽  
Author(s):  
Hongbing Wang ◽  
Daniel R. Storm
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cross Talk ◽  
Adenylyl Cyclases ◽  
The Central Nervous System

scholarly journals Oligodendrocyte-microglia cross-talk in the central nervous system

Immunology ◽  
2014 ◽  
Vol 141 (3) ◽  
pp. 302-313 ◽  
Author(s):  
Laura Peferoen ◽  
Markus Kipp ◽  
Paul van der Valk ◽  
Johannes M. van Noort ◽  
Sandra Amor
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cross Talk ◽  
The Central Nervous System

scholarly journals Astrocyte and Oligodendrocyte Cross-Talk in the Central Nervous System

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 600 ◽  
Author(s):  
Erik Nutma ◽  
Démi van Gent ◽  
Sandra Amor ◽  
Laura A. N. Peferoen
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cross Talk ◽  
Critical Role ◽  
Disease Onset ◽  
Cell Contact ◽  
Signalling Molecules ◽  
Direct Cell ◽  
The Central Nervous System ◽  
Health And Disease

Over the last decade knowledge of the role of astrocytes in central nervous system (CNS) neuroinflammatory diseases has changed dramatically. Rather than playing a merely passive role in response to damage it is clear that astrocytes actively maintain CNS homeostasis by influencing pH, ion and water balance, the plasticity of neurotransmitters and synapses, cerebral blood flow, and are important immune cells. During disease astrocytes become reactive and hypertrophic, a response that was long considered to be pathogenic. However, recent studies reveal that astrocytes also have a strong tissue regenerative role. Whilst most astrocyte research focuses on modulating neuronal function and synaptic transmission little is known about the cross-talk between astrocytes and oligodendrocytes, the myelinating cells of the CNS. This communication occurs via direct cell-cell contact as well as via secreted cytokines, chemokines, exosomes, and signalling molecules. Additionally, this cross-talk is important for glial development, triggering disease onset and progression, as well as stimulating regeneration and repair. Its critical role in homeostasis is most evident when this communication fails. Here, we review emerging evidence of astrocyte-oligodendrocyte communication in health and disease. Understanding the pathways involved in this cross-talk will reveal important insights into the pathogenesis and treatment of CNS diseases.

scholarly journals Cross-talk between reproduction and energy homeostasis: central impact of estrogens, leptin and kisspeptin signaling

2014 ◽  
Vol 17 (3) ◽  
Author(s):  
Casey C. Nestor ◽  
Martin J. Kelly ◽  
Oline K. Rønnekleiv
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cross Talk ◽  
Energy Homeostasis ◽  
The Central Nervous System ◽  
17Β Estradiol

AbstractThe central nervous system receives hormonal cues (e.g., estrogens and leptin, among others) that influence reproduction and energy homeostasis. 17β-estradiol (E

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