Differential Activation and Modulation of the Glucagon-Like Peptide-1 Receptor by Small Molecule Ligands

2013 ◽  
Vol 83 (4) ◽  
pp. 822-834 ◽  
Author(s):  
Denise Wootten ◽  
Emilia E. Savage ◽  
Francis S. Willard ◽  
Ana B. Bueno ◽  
Kyle W. Sloop ◽  
...  
Keyword(s):  
Small Molecule ◽  
Differential Activation ◽  
Small Molecule Ligands ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Molecular Characterisation of Small Molecule Agonists Effect on the Human Glucagon Like Peptide-1 Receptor Internalisation

PLoS ONE ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. e0154229 ◽  
Author(s):  
Aiysha Thompson ◽  
Jeffrey W. Stephens ◽  
Stephen C. Bain ◽  
Venkateswarlu Kanamarlapudi
Keyword(s):  
Small Molecule ◽  
Molecular Characterisation ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Novel insights into the dynamics behavior of glucagon-like peptide-1 receptor with its small molecule agonists

2018 ◽  
Vol 37 (15) ◽  
pp. 3976-3986 ◽  
Author(s):  
Khyati Girdhar ◽  
Budheswar Dehury ◽  
Mahender Kumar Singh ◽  
Vineeth P. Daniel ◽  
Abhinav Choubey ◽  
...  
Keyword(s):  
Small Molecule ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist Stimulates Insulin Secretion in Rodents and From Human Islets

Diabetes ◽  
2010 ◽  
Vol 59 (12) ◽  
pp. 3099-3107 ◽  
Author(s):  
K. W. Sloop ◽  
F. S. Willard ◽  
M. B. Brenner ◽  
J. Ficorilli ◽  
K. Valasek ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Small Molecule ◽  
Receptor Agonist ◽  
Human Islets ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues

2017 ◽  
Vol 60 (17) ◽  
pp. 7434-7446 ◽  
Author(s):  
Esben M. Bech ◽  
Manuel C. Martos-Maldonado ◽  
Pernille Wismann ◽  
Kasper K. Sørensen ◽  
Søren Blok van Witteloostuijn ◽  
...  
Keyword(s):  
Small Molecule ◽  
Half Life ◽  
Life Extension ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1
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