Demonstration of the Innate Electrophilicity of 4-(3-(Benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine (BETP), a Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor

2013 ◽  
Vol 41 (8) ◽  
pp. 1470-1479 ◽  
Author(s):  
Heather Eng ◽  
Raman Sharma ◽  
Thomas S. McDonald ◽  
David J. Edmonds ◽  
Jean-Philippe Fortin ◽  
...  
Keyword(s):  
Small Molecule ◽  
Allosteric Modulator ◽  
Positive Allosteric Modulator ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Discovery of an Orally Efficacious Positive Allosteric Modulator of the Glucagon-like Peptide-1 Receptor

2021 ◽  
Author(s):  
Francis S. Willard ◽  
David B. Wainscott ◽  
Aaron D. Showalter ◽  
Cynthia Stutsman ◽  
Wenzhen Ma ◽  
...  
Keyword(s):  
Allosteric Modulator ◽  
Positive Allosteric Modulator ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Molecular Basis of Action of a Small-Molecule Positive Allosteric Modulator Agonist at the Type 1 Cholecystokinin Holoreceptor

2018 ◽  
Vol 95 (3) ◽  
pp. 245-259 ◽  
Author(s):  
Aditya J. Desai ◽  
Ingrid Mechin ◽  
Karthigeyan Nagarajan ◽  
Celine Valant ◽  
Denise Wootten ◽  
...  
Keyword(s):  
Small Molecule ◽  
Molecular Basis ◽  
Allosteric Modulator ◽  
Positive Allosteric Modulator

scholarly journals Molecular Characterisation of Small Molecule Agonists Effect on the Human Glucagon Like Peptide-1 Receptor Internalisation

PLoS ONE ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. e0154229 ◽  
Author(s):  
Aiysha Thompson ◽  
Jeffrey W. Stephens ◽  
Stephen C. Bain ◽  
Venkateswarlu Kanamarlapudi
Keyword(s):  
Small Molecule ◽  
Molecular Characterisation ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Differential Activation and Modulation of the Glucagon-Like Peptide-1 Receptor by Small Molecule Ligands

2013 ◽  
Vol 83 (4) ◽  
pp. 822-834 ◽  
Author(s):  
Denise Wootten ◽  
Emilia E. Savage ◽  
Francis S. Willard ◽  
Ana B. Bueno ◽  
Kyle W. Sloop ◽  
...  
Keyword(s):  
Small Molecule ◽  
Differential Activation ◽  
Small Molecule Ligands ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1
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