Computational Analysis of Negative and Positive Allosteric Modulator Binding and Function in Metabotropic Glutamate Receptor 5 (In)Activation

James A. R. Dalton; Xavier Gómez-Santacana; Amadeu Llebaria; Jesús Giraldo

doi:10.1021/ci500127c

Computational Analysis of Negative and Positive Allosteric Modulator Binding and Function in Metabotropic Glutamate Receptor 5 (In)Activation

Journal of Chemical Information and Modeling ◽

10.1021/ci500127c ◽

2014 ◽

Vol 54 (5) ◽

pp. 1476-1487 ◽

Cited By ~ 19

Author(s):

James A. R. Dalton ◽

Xavier Gómez-Santacana ◽

Amadeu Llebaria ◽

Jesús Giraldo

Keyword(s):

Glutamate Receptor ◽

Computational Analysis ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

And Function

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Probing the Metabotropic Glutamate Receptor 5 (mGlu5) Positive Allosteric Modulator (PAM) Binding Pocket: Discovery of Point Mutations That Engender a “Molecular Switch” in PAM Pharmacology

Molecular Pharmacology ◽

10.1124/mol.112.083949 ◽

2013 ◽

Vol 83 (5) ◽

pp. 991-1006 ◽

Cited By ~ 60

Author(s):

Karen J. Gregory ◽

Elizabeth D. Nguyen ◽

Sean D. Reiff ◽

Emma F. Squire ◽

Shaun R. Stauffer ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Point Mutations ◽

Binding Pocket ◽

Molecular Switch ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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ADX47273 [S-(4-Fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: A Novel Metabotropic Glutamate Receptor 5-Selective Positive Allosteric Modulator with Preclinical Antipsychotic-Like and Procognitive Activities

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.108.136580 ◽

2008 ◽

Vol 327 (3) ◽

pp. 827-839 ◽

Cited By ~ 138

Author(s):

Feng Liu ◽

Steve Grauer ◽

Cody Kelley ◽

Rachel Navarra ◽

Radka Graf ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Correction to “A Novel Metabotropic Glutamate Receptor 5 Positive Allosteric Modulator Acts at a Unique Site and Confers Stimulus Bias to mGlu5 Signaling”

Molecular Pharmacology ◽

10.1124/mol.113.10er13 ◽

2013 ◽

Vol 84 (4) ◽

pp. 654-654

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Unique Site

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Preclinical profile of a novel metabotropic glutamate receptor 5 positive allosteric modulator

European Journal of Pharmacology ◽

10.1016/j.ejphar.2011.02.003 ◽

2011 ◽

Vol 659 (2-3) ◽

pp. 146-154 ◽

Cited By ~ 37

Author(s):

Nathan Spear ◽

Reto A. Gadient ◽

Deidre E. Wilkins ◽

MyLinh Do ◽

Jeffrey S. Smith ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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A Novel Metabotropic Glutamate Receptor 5 Positive Allosteric Modulator Acts at a Unique Site and Confers Stimulus Bias to mGlu5 Signaling

Molecular Pharmacology ◽

10.1124/mol.112.082891 ◽

2013 ◽

Vol 83 (4) ◽

pp. 835-847 ◽

Cited By ~ 57

Author(s):

M. J. Noetzel ◽

K. J. Gregory ◽

P. N. Vinson ◽

J. T. Manka ◽

S. R. Stauffer ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Unique Site

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Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator

European Journal of Pharmacology ◽

10.1016/j.ejphar.2010.02.057 ◽

2010 ◽

Vol 639 (1-3) ◽

pp. 40-46 ◽

Cited By ~ 45

Author(s):

Holger Rosenbrock ◽

Gert Kramer ◽

Scott Hobson ◽

Eliza Koros ◽

Marc Grundl ◽

...

Keyword(s):

Nmda Receptor ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Functional Interaction ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Effects of the metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on rats tested with the paired associates learning task in touchscreen-equipped operant conditioning chambers

Behavioural Brain Research ◽

10.1016/j.bbr.2015.12.029 ◽

2016 ◽

Vol 301 ◽

pp. 152-160 ◽

Cited By ~ 8

Author(s):

Brittney R. Lins ◽

John G. Howland

Keyword(s):

Operant Conditioning ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Learning Task ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Paired Associates

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Effects of a metabotropic glutamate receptor 5 positive allosteric modulator, CDPPB, on spatial learning in rodents

10.32469/10355/35152 ◽

2012 ◽

Author(s):

Stephanie Wade Fowler

Keyword(s):

Glutamate Receptor ◽

Spatial Learning ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Therapeutic effects of metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on phencyclidine-induced cognitive deficits in mice

Fundamental and Clinical Pharmacology ◽

10.1111/j.1472-8206.2012.01045.x ◽

2012 ◽

Vol 27 (5) ◽

pp. 483-488 ◽

Cited By ~ 29

Author(s):

Mao Horio ◽

Yuko Fujita ◽

Kenji Hashimoto

Keyword(s):

Glutamate Receptor ◽

Cognitive Deficits ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulator ◽

Therapeutic Effects ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Enantioselective Synthesis of a Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 5 (mGluR5) ReceptorviaDynamic Kinetic Resolution of α-Amino Ketones

Advanced Synthesis & Catalysis ◽

10.1002/adsc.201600329 ◽

2016 ◽

Vol 358 (13) ◽

pp. 2077-2082 ◽

Cited By ~ 9

Author(s):

Francisco González-Bobes ◽

Ronald Hanson ◽

Neil Strotman ◽

Zhiwei Guo ◽

Animesh Goswami

Keyword(s):

Glutamate Receptor ◽

Kinetic Resolution ◽

Metabotropic Glutamate Receptor ◽

Enantioselective Synthesis ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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