scholarly journals A Small-Molecule Oxocarbazate Inhibitor of Human Cathepsin L Blocks Severe Acute Respiratory Syndrome and Ebola Pseudotype Virus Infection into Human Embryonic Kidney 293T cells

2010 ◽  
Vol 78 (2) ◽  
pp. 319-324 ◽  
Author(s):  
Parag P. Shah ◽  
Tianhua Wang ◽  
Rachel L. Kaletsky ◽  
Michael C. Myers ◽  
Jeremy E. Purvis ◽  
...  
Keyword(s):  
Virus Infection ◽  
Severe Acute Respiratory Syndrome ◽  
Small Molecule ◽  
Cathepsin L ◽  
Human Embryonic Kidney ◽  
Pseudotype Virus ◽  
Human Cathepsin

scholarly journals A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 698 ◽  
Author(s):  
Dibyendu Dana ◽  
Sanjai K. Pathak
Keyword(s):  
Small Molecule ◽  
Chemical Biology ◽  
Small Molecule Inhibitors ◽  
Proteolytic Enzymes ◽  
Cathepsin L ◽  
Mechanisms Of Action ◽  
Discovery Process ◽  
Drug Discovery Process ◽  
Endopeptidase Activity ◽  
Human Cathepsin

Human cathepsin L belongs to the cathepsin family of proteolytic enzymes with primarily an endopeptidase activity. Although its primary functions were originally thought to be only of a housekeeping enzyme that degraded intracellular and endocytosed proteins in lysosome, numerous recent studies suggest that it plays many critical and specific roles in diverse cellular settings. Not surprisingly, the dysregulated function of cathepsin L has manifested itself in several human diseases, making it an attractive target for drug development. Unfortunately, several redundant and isoform-specific functions have recently emerged, adding complexities to the drug discovery process. To address this, a series of chemical biology tools have been developed that helped define cathepsin L biology with exquisite precision in specific cellular contexts. This review elaborates on the recently developed small molecule inhibitors and probes of human cathepsin L, outlining their mechanisms of action, and describing their potential utilities in dissecting unknown function.

Biphasic modulation of human cathepsin L by a novel cyanobacterial depsipeptide

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
B Miller ◽  
M Bertin ◽  
V Hook ◽  
WH Gerwick
Keyword(s):  
Cathepsin L ◽  
Human Cathepsin

scholarly journals Are RNA-Based Tests Sufficient for COVID-19 Diagnosis? An Inspiration of Three Asymptomatic Cases

2021 ◽  
Vol 30 ◽  
pp. 096368972098545
Author(s):  
Tao Hu ◽  
Xiao Liu ◽  
Qinan Yin ◽  
Xingting Duan ◽  
Li Yan
Keyword(s):  
Computed Tomography ◽  
Nucleic Acid ◽  
Virus Infection ◽  
Severe Acute Respiratory Syndrome ◽  
The Other ◽  
Computed Tomography Scan ◽  
Health Authorities ◽  
History Of ◽  
Tomography Scan ◽  
Nucleic Acid Tests

In this work, we discovered a new phenomenon—asymptomatic COVID-19 infection, or covert case, during the pandemic. All the 3 patients had a history of exposure, with no symptoms, and no abnormalities were found in computed tomography scan or lab tests. Except for case 2, the other patients’ severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) nucleic acid tests were negative. But their anti-SARS-COV-2 nucleocapsid antibody showed a dynamic trend, consistent with the process of virus infection and clearance. A growing number of asymptomatic or covert cases need more attention. Lack of surveillance may lead to another outbreak. We hope to demonstrate our cases to attract the attention of governments or health authorities that covert cases should be the focus as well.

scholarly journals Highly potent inhibitors of human cathepsin L identified by screening combinatorial pentapeptide amide collections

2000 ◽  
Vol 267 (16) ◽  
pp. 5085-5092 ◽  
Author(s):  
Achim Brinker ◽  
Ekkehard Weber ◽  
Dieter Stoll ◽  
Jürgen Voigt ◽  
Annett Müller ◽  
...  
Keyword(s):  
Cathepsin L ◽  
Human Cathepsin

Characterization and Crystallization of Recombinant Human Cathepsin L

1996 ◽  
Vol 228 (3) ◽  
pp. 792-796 ◽  
Author(s):  
Toshiyuki Nomura ◽  
Akira Fujishima ◽  
Yukio Fujisawa
Keyword(s):  
Cathepsin L ◽  
Human Cathepsin

Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks

2013 ◽  
Vol 23 (9) ◽  
pp. 2801-2807 ◽  
Author(s):  
Jiangli Song ◽  
Lindsay M. Jones ◽  
Gustavo E. Chavarria ◽  
Amanda K. Charlton-Sevcik ◽  
Adam Jantz ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Cathepsin L

scholarly journals Coronavirus (SARS-CoV-2) Pandemic: Future Challenges for Dental Practitioners

2020 ◽  
Vol 8 (11) ◽  
pp. 1704 ◽  
Author(s):  
Ioana Roxana Bordea ◽  
Edit Xhajanka ◽  
Sebastian Candrea ◽  
Simion Bran ◽  
Florin Onișor ◽  
...  
Keyword(s):  
Virus Infection ◽  
Severe Acute Respiratory Syndrome ◽  
Medical System ◽  
Protective Equipment ◽  
Degree Of Contamination ◽  
Face To Face ◽  
Dental Procedures ◽  
Dental Practitioners ◽  
Future Challenges ◽  
High Degree

In the context of the SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) pandemic, the medical system has been subjected to many changes. Face-to-face treatments have been suspended for a period of time. After the lockdown, dentists have to be aware of the modalities to protect themselves and their patients in order not to get infected. Dental practitioners are potentially exposed to a high degree of contamination with SARS-CoV-2 while performing dental procedures that produce aerosols. It should also be noted that the airways, namely the oral cavity and nostrils, are the access pathways for SARS-CoV-2. In order to protect themselves and their patients, they have to use full personal protective equipment. Relevant data regarding this pandemic are under evaluation and are still under test. In this article, we made a synthesis about the way in which SARS-CoV-2 spreads, how to diagnose a novel corona virus infection, what the possible treatments are, and which protective personal equipment we can use to stop its spreading.

scholarly journals Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

2016 ◽  
Vol 22 (10) ◽  
pp. 1101-1107 ◽  
Author(s):  
Miao Xu ◽  
Emily M Lee ◽  
Zhexing Wen ◽  
Yichen Cheng ◽  
Wei-Kai Huang ◽  
...  
Keyword(s):  
Cell Death ◽  
Virus Infection ◽  
Small Molecule ◽  
Zika Virus ◽  
Small Molecule Inhibitors ◽  
Drug Repurposing ◽  
Neural Cell ◽  
Zika Virus Infection
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