scholarly journals Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

2016 ◽  
Vol 22 (10) ◽  
pp. 1101-1107 ◽  
Author(s):  
Miao Xu ◽  
Emily M Lee ◽  
Zhexing Wen ◽  
Yichen Cheng ◽  
Wei-Kai Huang ◽  
...  
Keyword(s):  
Cell Death ◽  
Virus Infection ◽  
Small Molecule ◽  
Zika Virus ◽  
Small Molecule Inhibitors ◽  
Drug Repurposing ◽  
Neural Cell ◽  
Zika Virus Infection

scholarly journals Development of Small-Molecule Inhibitors Against Zika Virus Infection

2019 ◽  
Vol 10 ◽  
Author(s):  
Lili Wang ◽  
Ruiying Liang ◽  
Yaning Gao ◽  
Yanbai Li ◽  
Xiaoqian Deng ◽  
...  
Keyword(s):  
Virus Infection ◽  
Small Molecule ◽  
Zika Virus ◽  
Small Molecule Inhibitors ◽  
Zika Virus Infection

Identification of novel small-molecule inhibitors of Zika virus infection

2018 ◽  
Vol 28 (3) ◽  
pp. 452-458 ◽  
Author(s):  
Ewa D. Micewicz ◽  
Ronik Khachatoorian ◽  
Samuel W. French ◽  
Piotr Ruchala
Keyword(s):  
Virus Infection ◽  
Small Molecule ◽  
Zika Virus ◽  
Small Molecule Inhibitors ◽  
Zika Virus Infection

scholarly journals Identification/Optimization of Novel Small Molecule Inhibitors of Zika Virus Infection

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Ronik Khachatoorian ◽  
Ewa D. Micewicz ◽  
Anthony S. Buzzanco ◽  
Rana Riahi ◽  
Daphne Jin ◽  
...  
Keyword(s):  
Virus Infection ◽  
Small Molecule ◽  
Zika Virus ◽  
Small Molecule Inhibitors ◽  
Zika Virus Infection

The P-MAPA immunomodulator partially prevents apoptosis induced by Zika virus infection in THP-1 cells

2020 ◽  
Vol 21 ◽  
Author(s):  
Morganna C. Lima ◽  
Elisa A. N. Azevedo ◽  
Clarice N. L. de Morais ◽  
Larissa I. O. de Sousa ◽  
Bruno M. Carvalho ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Death ◽  
Virus Infection ◽  
Virus Replication ◽  
Zika Virus ◽  
Mammalian Cells ◽  
Caspase 3 ◽  
Neurological Complications ◽  
Zika Virus Infection

Background: Zika virus is an emerging arbovirus of global importance. ZIKV infection is associated with a range of neurological complications such as the Congenital Zika Syndrome and Guillain Barré Syndrome. Despite the magnitude of recent outbreaks, there is no specific therapy to prevent or to alleviate disease pathology. Objective: To investigate the role of P-MAPA immunomodulator in Zika-infected THP-1 cells. Methods: THP-1 cells were subjected at Zika virus infection (Multiplicity of Infection = 0.5) followed by treatment with P-MAPA for until 96 hours post-infection. After that, the cell death was analyzed by annexin+/ PI+ and caspase 3/ 7+ staining by flow cytometry. In addition, the virus replication and cell proliferation were accessed by RT-qPCR and Ki67 staining, respectively. Results: We demonstrate that P-MAPA in vitro treatment significantly reduces Zika virus-induced cell death and caspase-3/7 activation on THP-1 infected cells, albeit it has no role in virus replication and cell proliferation. Conclusions: Our study reveals that P-MAPA seems to be a satisfactory alternative to inhibits the effects of Zika virus infection in mammalian cells.

scholarly journals Zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Bruno S. F. Souza ◽  
Gabriela L. A. Sampaio ◽  
Ciro S. Pereira ◽  
Gubio S. Campos ◽  
Silvia I. Sardi ◽  
...  
Keyword(s):  
Cell Death ◽  
Virus Infection ◽  
Progenitor Cells ◽  
Zika Virus ◽  
Neural Progenitor Cells ◽  
Apoptotic Cell ◽  
Neural Progenitor ◽  
Apoptotic Cell Death ◽  
Zika Virus Infection ◽  
Human Neural Progenitor Cells

Drug Repurposing: New Treatments for Zika Virus Infection?

2016 ◽  
Vol 22 (11) ◽  
pp. 919-921 ◽  
Author(s):  
Feixiong Cheng ◽  
James L. Murray ◽  
Donald H. Rubin
Keyword(s):  
Virus Infection ◽  
Zika Virus ◽  
Drug Repurposing ◽  
Zika Virus Infection ◽  
New Treatments

Congenital Zika Virus Infection Paradigm: What is in the Wardrobe? A Narrative Review

2019 ◽  
Vol 1 (1) ◽  
pp. 49-56
Author(s):  
Mariam M. Mirambo ◽  
Lucas Matemba ◽  
Mtebe Majigo ◽  
Stephen E. Mshana
Keyword(s):  
Virus Infection ◽  
Neural Tube ◽  
Zika Virus ◽  
English Language ◽  
Case Reports ◽  
Case Series ◽  
Epidemiological Studies ◽  
Ocular Manifestations ◽  
Zika Virus Infection ◽  
N 93

Background: Zika virus infection during pregnancy has been recently associated with congenital microcephaly and other severe neural tube defects. However, the magnitude of confirmed cases and the scope of these anomalies have not been extensively documented. This review focuses on the magnitude of laboratory-confirmed congenital Zika virus cases among probable cases and describing the patterns of congenital anomalies allegedly caused by the Zika virus, information which will inform further research in this area. Methods: We conducted a literature search for English-language articles about congenital Zika virus infection using online electronic databases (PubMed/MEDLINE, POPLINE, Embase, Google Scholar, and Web of Knowledge). The search terms used were, “zika”, “pregnancy”, [year], “microcephaly”, “infants”, “children”, “neonates”, “foetuses”, “neural tube defect”, and “CNS manifestations” in different combinations. All articles reporting cases or case series between January 2015 and December 2016 were included. Data were entered into a Microsoft Excel database and analysed to obtain proportions of the confirmed cases and patterns of anomalies. Results: A total of 24 articles (11 case series, 9 case reports, and 4 others) were found to be eligible and included in this review. These articles reported 919 cases, with or without microcephaly, presumed to have congenital Zika virus infection. Of these cases, 884 (96.2%) had microcephaly. Of the 884 cases of microcephaly, 783 (88.6%) were tested for Zika virus infection, and 216 (27.6%; 95% confidence interval, 24.5% to 30.8%) were confirmed to be Zika virus-positive. In addition to microcephaly, other common abnormalities reported – out of 442 cases investigated – were calcifications of brain tissue (n=240, 54.3%), ventriculomegaly (n=93, 20.8%), cerebellar hypoplasia (n=52, 11.7%), and ocular manifestations (n=46, 10.4%). Conclusion: Based on the available literature, Zika virus infection during pregnancy might lead to a wide array of outcomes other than microcephaly. There is a need for more epidemiological studies in Zika-endemic areas, particularly in Africa, to ascertain the role of Zika virus in causing congenital neurological defects.

Congenital Zika Virus Infection Paradigm: What is in the Wardrobe? A Narrative Review

2019 ◽  
Vol 1 (1) ◽  
pp. 49-56
Author(s):  
Mariam M. Mirambo ◽  
Lucas Matemba ◽  
Mtebe Majigo ◽  
Stephen E. Mshana
Keyword(s):  
Virus Infection ◽  
Neural Tube ◽  
Zika Virus ◽  
English Language ◽  
Case Reports ◽  
Case Series ◽  
Epidemiological Studies ◽  
Ocular Manifestations ◽  
Zika Virus Infection ◽  
N 93

Background: Zika virus infection during pregnancy has been recently associated with congenital microcephaly and other severe neural tube defects. However, the magnitude of confirmed cases and the scope of these anomalies have not been extensively documented. This review focuses on the magnitude of laboratory-confirmed congenital Zika virus cases among probable cases and describing the patterns of congenital anomalies allegedly caused by the Zika virus, information which will inform further research in this area. Methods: We conducted a literature search for English-language articles about congenital Zika virus infection using online electronic databases (PubMed/MEDLINE, POPLINE, Embase, Google Scholar, and Web of Knowledge). The search terms used were, “zika”, “pregnancy”, [year], “microcephaly”, “infants”, “children”, “neonates”, “foetuses”, “neural tube defect”, and “CNS manifestations” in different combinations. All articles reporting cases or case series between January 2015 and December 2016 were included. Data were entered into a Microsoft Excel database and analysed to obtain proportions of the confirmed cases and patterns of anomalies. Results: A total of 24 articles (11 case series, 9 case reports, and 4 others) were found to be eligible and included in this review. These articles reported 919 cases, with or without microcephaly, presumed to have congenital Zika virus infection. Of these cases, 884 (96.2%) had microcephaly. Of the 884 cases of microcephaly, 783 (88.6%) were tested for Zika virus infection, and 216 (27.6%; 95% confidence interval, 24.5% to 30.8%) were confirmed to be Zika virus-positive. In addition to microcephaly, other common abnormalities reported – out of 442 cases investigated – were calcifications of brain tissue (n=240, 54.3%), ventriculomegaly (n=93, 20.8%), cerebellar hypoplasia (n=52, 11.7%), and ocular manifestations (n=46, 10.4%). Conclusion: Based on the available literature, Zika virus infection during pregnancy might lead to a wide array of outcomes other than microcephaly. There is a need for more epidemiological studies in Zika-endemic areas, particularly in Africa, to ascertain the role of Zika virus in causing congenital neurological defects.

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