The Effects of Central Nervous System-Active Valproic Acid Constitutional Isomers, Cyclopropyl Analogs, and Amide Derivatives on Neuronal Growth Cone Behavior

2006 ◽  
Vol 71 (3) ◽  
pp. 884-892 ◽  
Author(s):  
J. A. Shimshoni ◽  
E. C. Dalton ◽  
A. Jenkins ◽  
S. Eyal ◽  
K. Ewan ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Valproic Acid ◽  
Nervous System ◽  
Growth Cone ◽  
Neuronal Growth ◽  
Amide Derivatives ◽  
Neuronal Growth Cone

Use of calcium imaging technologies to dissect mechanisms underlying neuronal growth cone responses to environmental cues

1995 ◽  
Vol 53 ◽  
pp. 804-805
Author(s):  
C.V. Williams ◽  
S.B. Kater
Keyword(s):  
Nervous System ◽  
Growth Cone ◽  
Local Environment ◽  
Growth Cones ◽  
Neuronal Growth ◽  
Growth Inhibitory ◽  
Direct Growth ◽  
Neuronal Growth Cone ◽  
Mechanical Factors ◽  
Growth Promoting

Since calcium is a key second messenger in both the developmental formation and adult function of the nervous system, the ability to rapidly image changes in this molecule has added greatly to our understanding of how development of the nervous system is regulated. The nervous system is comprised of billions of neurons and glial cells that establish characteristic patterns of connections during development. Neurons extend processes that often must grow long distances to establish appropriate synaptic connections. Neurons perform a pathfinding behavior largely via the highly dynamic behavior of the neuronal growth cone at the distal tip of elongating processes. The motile behavior characteristic of growth cones allows the growth cone to survey the local environment, read local cues and respond to those cues with a change in behavior. A variety of cues are now known to direct growth cones (e.g. electrical activity, depolarization, growth factors, mechanical factors, neurotransmitters, substrate factors). This collection of factors includes both growth promoting and growth inhibitory influences.

scholarly journals Neuronal Growth Cone Retraction Relies on Proneurotrophin Receptor Signaling Through Rac

2011 ◽  
Vol 4 (202) ◽  
pp. ra82-ra82 ◽  
Author(s):  
K. Deinhardt ◽  
T. Kim ◽  
D. S. Spellman ◽  
R. E. Mains ◽  
B. A. Eipper ◽  
...  
Keyword(s):  
Growth Cone ◽  
Receptor Signaling ◽  
Neuronal Growth ◽  
Neuronal Growth Cone

scholarly journals DETERMINATION OF VALPROIC ACID IN TEAR BY GCQ -ASSESSEMENT OF THE CONCENTRATIONS OF DRUGS ACTING ON THE CENTRAL NERVOUS SYSTEM IN TEAR-

1998 ◽  
Vol 13 (supplement) ◽  
pp. 120-121
Author(s):  
Masaharu NAKAJIMA ◽  
Tomoko OHTA ◽  
Nozomi KAWAKAMI ◽  
Susumu YAMATO ◽  
Kenji SHIMADA ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Valproic Acid ◽  
Nervous System ◽  
The Central Nervous System

scholarly journals Strength in the Periphery: Growth Cone Biomechanics and Substrate Rigidity Response in Peripheral and Central Nervous System Neurons

2012 ◽  
Vol 102 (3) ◽  
pp. 452-460 ◽  
Author(s):  
Daniel Koch ◽  
William J. Rosoff ◽  
Jiji Jiang ◽  
Herbert M. Geller ◽  
Jeffrey S. Urbach
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Growth Cone ◽  
Substrate Rigidity

Ultra-short pulses to signal neuronal growth cone machinery

2007 ◽  
Author(s):  
Manoj Mathew ◽  
Ivan Amat-Roldan ◽  
Rosa Andres ◽  
Iain G. Cormack ◽  
David Artigas ◽  
...  
Keyword(s):  
Growth Cone ◽  
Neuronal Growth ◽  
Short Pulses ◽  
Neuronal Growth Cone

The neuronal growth cone as a specialized transduction system

BioEssays ◽  
1991 ◽  
Vol 13 (3) ◽  
pp. 127-134 ◽  
Author(s):  
Stephen M. Strittmatter ◽  
Mark C. Fishman
Keyword(s):  
Growth Cone ◽  
Neuronal Growth ◽  
Neuronal Growth Cone
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