The neuronal growth cone as a specialized transduction system

BioEssays ◽  
1991 ◽  
Vol 13 (3) ◽  
pp. 127-134 ◽  
Author(s):  
Stephen M. Strittmatter ◽  
Mark C. Fishman
Keyword(s):  
Growth Cone ◽  
Neuronal Growth ◽  
Neuronal Growth Cone

scholarly journals Neuronal Growth Cone Retraction Relies on Proneurotrophin Receptor Signaling Through Rac

2011 ◽  
Vol 4 (202) ◽  
pp. ra82-ra82 ◽  
Author(s):  
K. Deinhardt ◽  
T. Kim ◽  
D. S. Spellman ◽  
R. E. Mains ◽  
B. A. Eipper ◽  
...  
Keyword(s):  
Growth Cone ◽  
Receptor Signaling ◽  
Neuronal Growth ◽  
Neuronal Growth Cone

Ultra-short pulses to signal neuronal growth cone machinery

2007 ◽  
Author(s):  
Manoj Mathew ◽  
Ivan Amat-Roldan ◽  
Rosa Andres ◽  
Iain G. Cormack ◽  
David Artigas ◽  
...  
Keyword(s):  
Growth Cone ◽  
Neuronal Growth ◽  
Short Pulses ◽  
Neuronal Growth Cone

scholarly journals Rapid Impact of Progesterone on the Neuronal Growth Cone

Endocrinology ◽  
2013 ◽  
Vol 154 (10) ◽  
pp. 3784-3795 ◽  
Author(s):  
Laura Olbrich ◽  
Lisa Wessel ◽  
Ajeesh Balakrishnan-Renuka ◽  
Marion Böing ◽  
Beate Brand-Saberi ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Growth Cone ◽  
Progesterone Receptors ◽  
Laser Scanning Microscopy ◽  
Axonal Outgrowth ◽  
Neuronal Growth ◽  
Drg Neurons ◽  
Progesterone Treatment ◽  
Neuronal Growth Cone ◽  
The Impact

In the last two decades, sensory neurons and Schwann cells in the dorsal root ganglia (DRG) were shown to express the rate-limiting enzyme of the steroid synthesis, cytochrome P450 side-chain cleavage enzyme (P450scc), as well as the key enzyme of progesterone synthesis, 3β-hydroxysteroid dehydrogenase (3β-HSD). Thus, it was well justified to consider that DRG neurons similarly are able to synthesize progesterone de novo from cholesterol. Because direct progesterone effects on axonal outgrowth in peripheral neurons have not been investigated up to now, the present study provides the first insights into the impact of exogenous progesterone on axonal outgrowth in DRG neurons. Our studies including microinjection and laser scanning microscopy demonstrate morphological changes especially in the neuronal growth cones after progesterone treatment. Furthermore, we were able to detect a distinctly enhanced motility only a few minutes after the start of progesterone treatment using time-lapse imaging. Investigation of the cytoskeletal distribution in the neuronal growth cone before, during, and after progesterone incubation revealed a rapid reorganization of actin filaments. To get a closer idea of the underlying receptor mechanisms, we further studied the expression of progesterone receptors in DRG neurons using RT-PCR and immunohistochemistry. Thus, we could demonstrate for the first time that classical progesterone receptor (PR) A and B and the recently described progesterone receptor membrane component 1 (PGRMC1) are expressed in DRG neurons. Antagonism of the classical progesterone receptors by mifepristone revealed that the observed progesterone effects are transmitted through PR-A and PR-B.

Sign in / Sign up

Export Citation Format

Share Document