Curcumin Inhibits Hypoxia-Inducible Factor-1 by Degrading Aryl Hydrocarbon Receptor Nuclear Translocator: A Mechanism of Tumor Growth Inhibition

Hyunsung Choi; Yang-Sook Chun; Seung-Won Kim; Myung-Suk Kim; Jong-Wan Park

doi:10.1124/mol.106.025817

Curcumin Inhibits Hypoxia-Inducible Factor-1 by Degrading Aryl Hydrocarbon Receptor Nuclear Translocator: A Mechanism of Tumor Growth Inhibition

Molecular Pharmacology ◽

10.1124/mol.106.025817 ◽

2006 ◽

Vol 70 (5) ◽

pp. 1664-1671 ◽

Cited By ~ 126

Author(s):

Hyunsung Choi ◽

Yang-Sook Chun ◽

Seung-Won Kim ◽

Myung-Suk Kim ◽

Jong-Wan Park

Keyword(s):

Tumor Growth ◽

Growth Inhibition ◽

Aryl Hydrocarbon Receptor ◽

Hypoxia Inducible Factor ◽

Tumor Growth Inhibition ◽

Hypoxia Inducible Factor 1 ◽

Aryl Hydrocarbon

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Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition

BMC Cancer ◽

10.1186/1471-2407-12-293 ◽

2012 ◽

Vol 12 (1) ◽

Cited By ~ 38

Author(s):

Sreenivasulu Chintala ◽

Tanbir Najrana ◽

Karoly Toth ◽

Shousong Cao ◽

Farukh A Durrani ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Tumor Growth ◽

Growth Inhibition ◽

Renal Cell ◽

Clear Cell ◽

Hypoxia Inducible Factor ◽

Tumor Growth Inhibition ◽

Cell Renal Cell Carcinoma ◽

Von Hippel Lindau ◽

Hypoxia Inducible Factor 1

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The aryl hydrocarbon receptor nuclear translocator‐interacting peptide 1 suppresses hypoxia inducible factor‐1 alpha signaling via an Arnt‐dependent mechanism

The FASEB Journal ◽

10.1096/fasebj.25.1_supplement.1007.5 ◽

2011 ◽

Vol 25 (S1) ◽

Author(s):

Yu Wang ◽

Yanjie Li ◽

Depeng Peng ◽

William K Chan

Keyword(s):

Aryl Hydrocarbon Receptor ◽

Hypoxia Inducible Factor ◽

Hypoxia Inducible Factor 1 ◽

Aryl Hydrocarbon ◽

Dependent Mechanism

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Conditional Disruption of the Aryl Hydrocarbon Receptor Nuclear Translocator (Arnt) Gene Leads to Loss of Target Gene Induction by the Aryl Hydrocarbon Receptor and Hypoxia-Inducible Factor 1

Molecular Endocrinology ◽

10.1210/me.14.10.1674 ◽

2000 ◽

Vol 14 (10) ◽

pp. 1674-1681 ◽

Cited By ~ 26

Author(s):

S. Tomita

Keyword(s):

Aryl Hydrocarbon Receptor ◽

Target Gene ◽

Hypoxia Inducible Factor ◽

Gene Induction ◽

Hypoxia Inducible Factor 1 ◽

Aryl Hydrocarbon ◽

Target Gene Induction

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Interrelated Roles for the Aryl Hydrocarbon Receptor and Hypoxia Inducible Factor-1α in the Immune Response to Infection

Current Immunology Reviews ◽

10.2174/1573395510666141105234917 ◽

2015 ◽

Vol 11 (1) ◽

pp. 43-54

Author(s):

Sagie Wagage ◽

Christopher Hunter

Keyword(s):

Immune Response ◽

Aryl Hydrocarbon Receptor ◽

Hypoxia Inducible Factor ◽

Hypoxia Inducible Factor 1 ◽

Aryl Hydrocarbon

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siRNA-mediated knockdown of aryl hydrocarbon receptor nuclear translocator 2 affects hypoxia-inducible factor-1 regulatory signaling and metabolism in human breast cancer cells

FEBS Letters ◽

10.1016/j.febslet.2011.09.017 ◽

2011 ◽

Vol 585 (20) ◽

pp. 3310-3315 ◽

Cited By ~ 16

Author(s):

Xian-Yang Qin ◽

Feifei Wei ◽

Jun Yoshinaga ◽

Junzo Yonemoto ◽

Masaru Tanokura ◽

...

Keyword(s):

Breast Cancer ◽

Aryl Hydrocarbon Receptor ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Hypoxia Inducible Factor ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Hypoxia Inducible Factor 1 ◽

Aryl Hydrocarbon

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Suppression of the hypoxia inducible factor-1 function by redistributing the aryl hydrocarbon receptor nuclear translocator from nucleus to cytoplasm

Cancer Letters ◽

10.1016/j.canlet.2012.01.037 ◽

2012 ◽

Vol 320 (1) ◽

pp. 111-121 ◽

Cited By ~ 5

Author(s):

Yu Wang ◽

Yanjie Li ◽

Depeng Wang ◽

Yi Li ◽

Abraham Chang ◽

...

Keyword(s):

Aryl Hydrocarbon Receptor ◽

Hypoxia Inducible Factor ◽

Hypoxia Inducible Factor 1 ◽

Aryl Hydrocarbon

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A cell-penetrating peptide suppresses the hypoxia inducible factor-1 function by binding to the helix-loop-helix domain of the aryl hydrocarbon receptor nuclear translocator

Chemico-Biological Interactions ◽

10.1016/j.cbi.2013.02.003 ◽

2013 ◽

Vol 203 (2) ◽

pp. 401-411 ◽

Cited By ~ 4

Author(s):

Yu Wang ◽

John D. Thompson ◽

William K. Chan

Keyword(s):

Aryl Hydrocarbon Receptor ◽

Hypoxia Inducible Factor ◽

Cell Penetrating Peptide ◽

Hypoxia Inducible Factor 1 ◽

Helix Loop Helix ◽

Aryl Hydrocarbon ◽

Cell Penetrating ◽

A Cell

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Divergent Expression Patterns for Hypoxia-Inducible Factor-1 and Aryl Hydrocarbon Receptor Nuclear Transporter-2 in Developing Kidney

Journal of the American Society of Nephrology ◽

10.1097/01.asn.0000141464.02967.29 ◽

2004 ◽

Vol 15 (10) ◽

pp. 2569-2578 ◽

Cited By ~ 17

Author(s):

P. B. Freeburg

Keyword(s):

Aryl Hydrocarbon Receptor ◽

Expression Patterns ◽

Hypoxia Inducible Factor ◽

Hypoxia Inducible Factor 1 ◽

Aryl Hydrocarbon ◽

Developing Kidney

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Tumor growth inhibition with bispecific antibody fragments in a syngeneic mouse melanoma model: The role of targeted T-cell costimulation via CD28

Immunology Letters ◽

10.1016/s0165-2478(97)88217-x ◽

1997 ◽

Vol 56 (1-3) ◽

pp. 340

Author(s):

L Hovest

Keyword(s):

T Cell ◽

Tumor Growth ◽

Growth Inhibition ◽

Bispecific Antibody ◽

Antibody Fragments ◽

Tumor Growth Inhibition ◽

Syngeneic Mouse ◽

Mouse Melanoma Model ◽

Melanoma Model

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Tumor Growth Inhibition by a Purine Analogue

Nutrition Reviews ◽

10.1111/j.1753-4887.1949.tb02283.x ◽

2009 ◽

Vol 7 (9) ◽

pp. 271-273

Keyword(s):

Tumor Growth ◽

Growth Inhibition ◽

Tumor Growth Inhibition ◽

Purine Analogue

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