Deorphanization of GPRC6A: A Promiscuous l-α-Amino Acid Receptor with Preference for Basic Amino Acids

2004 ◽  
Vol 67 (3) ◽  
pp. 589-597 ◽  
Author(s):  
Petrine Wellendorph ◽  
Kasper B. Hansen ◽  
Anders Balsgaard ◽  
Jeremy R. Greenwood ◽  
Jan Egebjerg ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Acid Receptor ◽  
Basic Amino Acids

scholarly journals Determination of Methylated Basic Amino Acids with the Amino Acid Analyzer

1973 ◽  
Vol 248 (7) ◽  
pp. 2387-2391 ◽  
Author(s):  
Gladys E. Deibler ◽  
Russell E. Martenson
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Basic Amino Acids ◽  
Amino Acid Analyzer

Basic amino acid induced isomerization of a spiropyran: towards visual recognition of basic amino acids in water

2007 ◽  
Vol 31 (11) ◽  
pp. 1878 ◽  
Author(s):  
Yuanyuan Liu ◽  
Meigong Fan ◽  
Shuxiao Zhang ◽  
Xiaohai Sheng ◽  
Jiannian Yao
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Visual Recognition ◽  
Basic Amino Acid ◽  
Basic Amino Acids

scholarly journals Amino acid recognition by fine tuning the association constants: tailored naphthalimides in pillar[5]arene-based indicator displacement assays

RSC Advances ◽  
2016 ◽  
Vol 6 (89) ◽  
pp. 86269-86275 ◽  
Author(s):  
Márton Bojtár ◽  
Adrien Paudics ◽  
Dóra Hessz ◽  
Miklós Kubinyi ◽  
István Bitter
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Association Constants ◽  
Fine Tuning ◽  
Supramolecular Interactions ◽  
Basic Amino Acids ◽  
Anchoring Groups ◽  
Displacement Assays ◽  
Amino Acid Recognition

Three naphthalimide derivatives were synthesized with different anchoring groups to adjust the supramolecular interactions with carboxylato-pillar[5]arene. The complexes were used as indicator displacement assays for basic amino acids and diamines.

Photochromic and photothermal hydrogel derived from natural amino acid and heteropoly acid

Soft Matter ◽  
2021 ◽  
Author(s):  
Xue Wang ◽  
Xiaohuan Liu ◽  
Zhiyuan Ma ◽  
Chuanling Mu ◽  
Wen Li
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Heteropoly Acid ◽  
Acidic Condition ◽  
Heteropoly Acids ◽  
Natural Amino Acid ◽  
Basic Amino Acids

A new kind of supramolecular hydrogels have been designed and synthesized via the co-assembly of basic amino acids (AAs) and heteropoly acids (HPAs) under acidic condition. The formation of gel-like...

Self-healing hydrogels triggered by amino acids

2016 ◽  
Vol 3 (12) ◽  
pp. 1699-1704 ◽  
Author(s):  
Nicola Zanna ◽  
Andrea Merlettini ◽  
Claudia Tomasini
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Aspartic Acid ◽  
Chemical Properties ◽  
Aromatic Amino Acids ◽  
Self Healing ◽  
Acidic Amino Acid ◽  
Basic Amino Acids

Nine amino acids with different chemical properties have been chosen to promote the formation of hydrogels based on the bolamphiphilic gelator A: three basic amino acids (arginine, histidine and lysine), one acidic amino acid (aspartic acid), two neutral aliphatic amino acids (alanine and serine) and three neutral aromatic amino acids (phenylalanine, tyrosine and tryptophan).

Influence of organic cations on basic amino-acid uptake by human placental villi

1995 ◽  
Vol 7 (6) ◽  
pp. 1491
Author(s):  
RB Krishna ◽  
J Dancis ◽  
M Levitz
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Basic Amino Acid ◽  
Amino Acid Uptake ◽  
Progressive Increase ◽  
Amino Acid Transporters ◽  
Acid Uptake ◽  
Chorionic Villi ◽  
Basic Amino Acids ◽  
Kinetics Of

Human placental chorionic villi were incubated for 30 min with [3H]lysine or [3H]arginine and the distribution ratios (intracellular:extracellular concentrations) were determined. The ratios remained unchanged when Na+ in Earle's buffered salt solution was replaced with Li+. When Na+ was replaced with choline there was a significant increase is distribution ratios (lysine 1.34 +/- 0.33 v. 3.99 +/- 0.15, arginine 1.95 +/- 0.37 v. 5.05 +/- 1.16). Leucine, a neutral amino acid with a Na(+)-independent transport system, was unaffected by choline substitution. The distribution ratio for alanine, which is Na(+)-dependent, was reduced (2.50 +/- 0.41 v. 1.45 +/- 0.20). Two other quarternary amines, acetyl-beta-methylcholine and tetraethylammonium chloride (TEA) caused similar increases in the distribution ratios of the basic amino acids. Hordenine, a tertiary amine, was less effective and there was little or no effect with ephedrine, a secondary amine. The choline effect was first observable at concentrations of 105 mM. With TEA, there was a progressive increase in distribution ratios beginning at 29 mM. Lysine efflux was measured after incubation of villi with lysine in Earle's buffer or choline buffer. Lysine was rapidly released to the fresh medium with 25% more retained in choline-exposed villi. The amines may cause alterations in the kinetics of basic amino-acid transporters or may modify other aspects of placental physiology permitting an increase retention of the basic amino acids.

Renal reabsorption of amino acids

1962 ◽  
Vol 203 (5) ◽  
pp. 891-896 ◽  
Author(s):  
Marian Ruszkowski ◽  
Cizesław Arasimowicz ◽  
Jan Knapowski ◽  
Jan Steffen ◽  
Krystyna Weiss
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Transport Mechanism ◽  
Flow Analysis ◽  
Proximal Segment ◽  
Renal Tubules ◽  
Basic Amino Acids ◽  
Tubular Transport ◽  
The Common ◽  
Stop Flow

Using the method of stop flow analysis an attempt was made to localize the process of amino acid reabsorption in the nephron of the dog. Special attention was given to the group of basic amino acids and cystine believed to share a common tubular transport mechanism. The evidence obtained in this study points clearly to the proximal segment as the site of intensive reabsorption of all amino acids investigated. During the infusion of arginine, lysine or ornithine, an increased excretion of two remaining basic amino acids plus cystine was observed, as a rule. Successful attempts were made to infuse cystine intravenously. The results of these experiments did provide the missing link for the hypothesis derived by Dent and Rose ( Quart. J. Med. 20: 205, 1951) concerning the common transport mechanism of arginine, ornithine, lysine, and cystine in the renal tubules. The functional cystinuria, which can be induced by saturating the common reabsorptive pathway with each of the above-mentioned amino acids, is fully reversible.

Observations sur une méthode de dosage de la proline libre dans les extraits de plantes

1979 ◽  
Vol 57 (18) ◽  
pp. 1851-1854 ◽  
Author(s):  
Roger Paquin ◽  
Pierre Lechasseur
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Plant Extracts ◽  
Correction Factors ◽  
Basic Amino Acids ◽  
Precise Estimation ◽  
Extraits De Plantes

Folin-type resins used to purify plant extracts of basic amino acids that interfere with proline determination are not selective and partially retain this amino acid and the basic amino acids. Therefore, their use should be avoided, otherwise correction factors must be introduced. Modifications to another method allow a more rapid and precise estimation of proline.

Preparation of A Spherical Cellulose Adsorbent as Amino Acid Sorbent

2011 ◽  
Vol 197-198 ◽  
pp. 899-905 ◽  
Author(s):  
Chun Xiang Lin ◽  
Ming Hua Liu ◽  
Huai Yu Zhan
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Reaction Time ◽  
Acrylic Acid ◽  
Reaction Temperature ◽  
Monomer Concentration ◽  
Initiator Concentration ◽  
Basic Amino Acids ◽  
Cellulose Adsorbent

The spherical cellulose adsorbent was prepared by grafting acrylic acid onto the spherical cellulose beads prepared by NMMO method. The effecting factors, e.g., monomer concentration, initiator concentration, reaction temperature and reaction time were optimized by the orthogonal and signal-factor experiments and the structure of the adsorbent was characterized by FTIR and SEM. The graft mechanism was also discussed. Moreover, the spherical cellulose adsorbents were shown to behave as good sorbents for basic amino acids L-Arg, L-Lys and L-His.

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