Inhibition of Excitatory Synaptic Transmission in Hippocampal Neurons by Levetiracetam Involves Zn2+-Dependent GABA Type A Receptor–Mediated Presynaptic Modulation

2013 ◽  
Vol 348 (2) ◽  
pp. 246-259 ◽  
Author(s):  
Masahito Wakita ◽  
Naoki Kotani ◽  
Kyuya Kogure ◽  
Norio Akaike
Keyword(s):  
Synaptic Transmission ◽  
Hippocampal Neurons ◽  
Type A ◽  
Excitatory Synaptic Transmission ◽  
Presynaptic Modulation

scholarly journals Hippocampal neurons in direct contact with astrocytes exposed to amyloid β25-35 exhibit reduced excitatory synaptic transmission

IBRO Reports ◽  
2019 ◽  
Vol 7 ◽  
pp. 34-41 ◽  
Author(s):  
Kohei Oyabu ◽  
Hiroki Kiyota ◽  
Kaori Kubota ◽  
Takuya Watanabe ◽  
Shutaro Katsurabayashi ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Hippocampal Neurons ◽  
Direct Contact ◽  
Excitatory Synaptic Transmission

Physiology of excitatory synaptic transmission in cultures of dissociated rat hippocampus

1985 ◽  
Vol 54 (3) ◽  
pp. 701-713 ◽  
Author(s):  
S. M. Rothman ◽  
M. Samaie
Keyword(s):  
Amino Acid ◽  
Synaptic Transmission ◽  
Hippocampal Neurons ◽  
Excitatory Amino Acid ◽  
Excitatory Synaptic Transmission ◽  
Voltage Sensitivity ◽  
Voltage Dependent ◽  
Synaptic Receptors ◽  
Amino Acid Antagonists ◽  
Excitatory Amino Acid Antagonists

Cultures of dissociated rat hippocampal neurons were used to study the physiology and pharmacology of excitatory synaptic transmission. Rat hippocampal neurons depolarized when they were exposed to the excitatory transmitter candidates, glutamate (Glu) and aspartate (Asp), as well as to the pure excitatory amino acid agonists, N-methyl-D-aspartate (NMDA) and kainate (KA). Quisqualate (QUIS) produced responses in about two-thirds of these cells. Glu responses were much more effectively blocked by the excitatory amino acid antagonists cis-2,3-piperidine dicarboxylic acid (PDA) and gamma-D-glutamylglycine (DGG) than by D-2-amino-5-phosphonovaleric acid (APV) or D-alpha-aminoadipic acid (DAA). Asp depolarizations were depressed by all four antagonists. Monosynaptic excitatory postsynaptic potentials (EPSPs) were only decreased by PDA and DGG. Postsynaptic responses to both Glu and Asp were very voltage dependent, decreasing as the membrane potential was hyperpolarized up to 70 mV below resting levels. The EPSP, however, increased linearly in the hyperpolarized range. NMDA responses were also voltage dependent, while KA and QUIS responses behaved like EPSPs. DGG very effectively blocked KA, but not QUIS, depolarizations. APV, which only partially depressed Glu responses, markedly diminished their voltage sensitivity. These results all suggest that EPSPs in this preparation are produced by Glu acting at KA-type synaptic receptors. Exogenous Glu probably acts at both synaptic KA receptors and extrasynaptic NMDA receptors, which explains why it produces a voltage-dependent response different from the EPSP.

scholarly journals Co-stimulation of mGluR5 andN-Methyl-D-aspartate Receptors Is Required for Potentiation of Excitatory Synaptic Transmission in Hippocampal Neurons

2003 ◽  
Vol 278 (30) ◽  
pp. 27742-27749 ◽  
Author(s):  
Suhas A. Kotecha ◽  
Michael F. Jackson ◽  
Azza Al-Mahrouki ◽  
John C. Roder ◽  
Beverley A. Orser ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Hippocampal Neurons ◽  
Excitatory Synaptic Transmission ◽  
Stimulation Of

Excitatory synaptic transmission is depressed in cultured hippocampal neurons of APP/PS1 mice

2009 ◽  
Vol 30 (8) ◽  
pp. 1227-1237 ◽  
Author(s):  
Christina Priller ◽  
Gerda Mitteregger ◽  
Sandra Paluch ◽  
Neville Vassallo ◽  
Matthias Staufenbiel ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Hippocampal Neurons ◽  
Excitatory Synaptic Transmission ◽  
Cultured Hippocampal Neurons

scholarly journals CLC-3 Channels Modulate Excitatory Synaptic Transmission in Hippocampal Neurons

Neuron ◽  
2006 ◽  
Vol 52 (2) ◽  
pp. 321-333 ◽  
Author(s):  
Xue Qing Wang ◽  
Ludmila V. Deriy ◽  
Sarah Foss ◽  
Ping Huang ◽  
Fred S. Lamb ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Hippocampal Neurons ◽  
Excitatory Synaptic Transmission
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