Potassium channel blocker-induced presynaptic modulation of inhibitory synaptic transmission in hippocampal neurons of rats

1998 ◽  
Vol 30 (4-5) ◽  
pp. 275-278
Author(s):  
D. V. Vasil'yev ◽  
E. V. Isaeva ◽  
S. A. Fedulova ◽  
N. S. Veselovskii
Keyword(s):  
Synaptic Transmission ◽  
Potassium Channel ◽  
Hippocampal Neurons ◽  
Channel Blocker ◽  
Potassium Channel Blocker ◽  
Presynaptic Modulation ◽  
Inhibitory Synaptic Transmission

Epileptiform activity in the hippocampus produced by tetraethylammonium

1990 ◽  
Vol 64 (4) ◽  
pp. 1077-1088 ◽  
Author(s):  
P. A. Rutecki ◽  
F. J. Lebeda ◽  
D. Johnston
Keyword(s):  
Potassium Channel ◽  
Voltage Clamp ◽  
Channel Blocker ◽  
Mossy Fiber ◽  
Reversal Potential ◽  
Evoked Response ◽  
Epileptiform Discharge ◽  
Extracellular Potassium ◽  
Potassium Channel Blocker ◽  
Epileptiform Discharges

1. The epileptiform discharges in the CA3 region of the rat hippocampal slice produced by bath application of the potassium channel blocker tetraethylammonium (TEA) were investigated. The effects of a convulsant (5 mM) and subconvulsant (0.5 mM) concentration of TEA on the mossy fiber-evoked synaptic currents were studied by the use of voltage-clamp techniques to determine whether TEA, like 4-aminopyridine (4-AP), another potassium channel blocker and convulsant, increased both inhibitory and excitatory components of the synaptic response. 2. At extracellular potassium concentrations of 2.5 mM, TEA (5 mM) was found to produce spontaneously occurring epileptiform discharges that could be recorded extracellularly. The intracellular correlate of the epileptiform discharge, the paroxysmal depolarizing shift (PDS), could be reversed in polarity by depolarizing the membrane and was associated with a large increase in membrane conductance. These results suggest that a synaptically mediated potential underlies the generation of the epileptiform discharge. 3. The reversal potential for the PDS was dependent on the time, relative to the extracellularly recorded field discharge, at which the measurement was made. In current clamp the mean reversal potential of the PDS measured at the midpoint of the extracellular discharge was -3.3 +/- 2.9 (SE) mV (n = 9). The reversal potential of the PDS was considerably more negative when measured either before or after the midpoint of the extracellular discharge, suggesting the presence of an inhibitory synaptic component. In voltage clamp similar results were obtained and a large conductance change was found to be associated with the PDS. These results suggest that the synaptic conductance associated with the PDS has both inhibitory and excitatory components. 4. TEA increased significantly the mossy fiber-evoked, early-inhibitory conductance. A convulsant concentration (5 mM) increased the conductance measured 15 ms after the stimulus from 39.7 +/- 8.7 to 87.2 +/- 8.0 nS (n = 6). The reversal potential associated with the conductance depolarized from -68.3 +/- 3.4 to -58.3 +/- 4.0 mV after 5 mM TEA. A subconvulsant concentration of TEA (0.5 mM) also increased the conductance of the mossy fiber-evoked response at 15 ms after the stimulus from 49.5 +/- 3.1 to 63.1 +/- 6.1 nS (n = 4) without an associated shift in reversal potential. 5. The late-inhibitory component of the mossy fiber-evoked response, when present, was increased by 5 mM TEA and unchanged by 0.5 mM TEA. 6. The excitatory mossy fiber-evoked synaptic current was studied in the presence of picrotoxin and was found to be increased and prolonged by 5 mM TEA.(ABSTRACT TRUNCATED AT 400 WORDS)

scholarly journals Corrigendum to “Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK” [Peptides 99 (2018) 169–178]

Peptides ◽  
2018 ◽  
Vol 101 ◽  
pp. 234
Author(s):  
Bankala Krishnarjuna ◽  
Christopher A. MacRaild ◽  
Punnepalli Sunanda ◽  
Rodrigo A.V. Morales ◽  
Steve Peigneur ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Channel Blocker ◽  
Sea Anemone ◽  
Potassium Channel Blocker ◽  
Anemonia Sulcata

scholarly journals Anti-Arrhythmic Action of an ATP-Sensitive Potassium Channel Blocker Against Atrial Fibrillation Associated with Beta-Adrenergic Stress in Rat Hearts

2011 ◽  
Vol 100 (3) ◽  
pp. 197a
Author(s):  
Andrew F. James ◽  
Shang Jin Kim ◽  
Haifei Zhang ◽  
Stephanie C. Choisy ◽  
Hua Lin ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Potassium Channel ◽  
Channel Blocker ◽  
Beta Adrenergic ◽  
Potassium Channel Blocker ◽  
Rat Hearts

Potassium channel blocker inhibits the formation and electroactivity of Geobacter biofilm

2020 ◽  
Vol 705 ◽  
pp. 135796 ◽  
Author(s):  
Xianyue Jing ◽  
Yuting Yang ◽  
Zhihao Ai ◽  
Shanshan Chen ◽  
Shungui Zhou
Keyword(s):  
Potassium Channel ◽  
Channel Blocker ◽  
Potassium Channel Blocker

Beyond hemostasis: A potassium channel blocker snake venom serine protease with potential antitumor activity

Toxicon ◽  
2020 ◽  
Vol 177 ◽  
pp. S8-S9
Author(s):  
Johara Boldrini-França ◽  
Ernesto Lopes Pinheiro-Junior ◽  
Steve Peigneur ◽  
Tássia Rafaella Costa ◽  
Rafael Junqueira Borges ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Potassium Channel ◽  
Serine Protease ◽  
Snake Venom ◽  
Channel Blocker ◽  
Potassium Channel Blocker ◽  
Potential Antitumor

Effect of HERG-like Potassium Channel Blocker on the Carotid Body Chemoreception

2003 ◽  
pp. 117-122 ◽  
Author(s):  
Shinobu Osanai ◽  
Toru Takahashi ◽  
Hitoshi Nakano ◽  
Yoshinobu Ohsaki ◽  
Kenjiro Kikuchi
Keyword(s):  
Potassium Channel ◽  
Carotid Body ◽  
Channel Blocker ◽  
Potassium Channel Blocker

Cicutoxin fromCicuta virosa— A New and Potent Potassium Channel Blocker in T Lymphocytes

1996 ◽  
Vol 219 (2) ◽  
pp. 332-336 ◽  
Author(s):  
Ulf Strauß ◽  
Ute Wittstock ◽  
Rudolf Schubert ◽  
Eberhard Teuscher ◽  
Stefan Jung ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Potassium Channel ◽  
Channel Blocker ◽  
Potassium Channel Blocker
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