Evaluation of Accelerator Mass Spectrometry in a Human Mass Balance and Pharmacokinetic Study–Experience with14C-labeled (R)-6-[Amino(4- chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1- methyl-2(1H)-quinolinone (R115777), a Farnesyl Transferase Inhibitor

R. C. Garner; I. Goris; A. A. E. Laenen; E. Vanhoutte; W. Meuldermans; S. Gregory; J. V. Garner; D. Leong; M. Whattam; A. Calam; C. A. W. Snel

doi:10.1124/dmd.30.7.823

Evaluation of Accelerator Mass Spectrometry in a Human Mass Balance and Pharmacokinetic Study–Experience with14C-labeled (R)-6-[Amino(4- chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1- methyl-2(1H)-quinolinone (R115777), a Farnesyl Transferase Inhibitor

Drug Metabolism and Disposition ◽

10.1124/dmd.30.7.823 ◽

2002 ◽

Vol 30 (7) ◽

pp. 823-830 ◽

Cited By ~ 61

Author(s):

R. C. Garner ◽

I. Goris ◽

A. A. E. Laenen ◽

E. Vanhoutte ◽

W. Meuldermans ◽

...

Keyword(s):

Mass Spectrometry ◽

Mass Balance ◽

Pharmacokinetic Study ◽

Accelerator Mass Spectrometry ◽

Farnesyl Transferase ◽

Farnesyl Transferase Inhibitor ◽

Study Experience

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Mass balance study with ixabepilone using Accelerator Mass Spectrometry

Journal of Clinical Oncology ◽

10.1200/jco.2004.22.14_suppl.2036 ◽

2004 ◽

Vol 22 (14_suppl) ◽

pp. 2036-2036 ◽

Cited By ~ 1

Author(s):

J. H. Beumer ◽

G. Lappin ◽

M. Cohen ◽

S. Galbraith ◽

R. C. Garner ◽

...

Keyword(s):

Mass Spectrometry ◽

Mass Balance ◽

Accelerator Mass Spectrometry ◽

Balance Study ◽

Mass Balance Study

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Quantitative analysis of the farnesyl transferase inhibitor lonafarnib (Sarasar™, SCH66336) in human plasma using high-performance liquid chromatography coupled with tandem mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.2046 ◽

2005 ◽

Vol 19 (15) ◽

pp. 2187-2192 ◽

Cited By ~ 8

Author(s):

Natalie M. G. M. Appels ◽

Maria J. van Maanen ◽

Hilde Rosing ◽

Jan H. M. Schellens ◽

Jos H. Beijnen

Keyword(s):

Mass Spectrometry ◽

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Quantitative Analysis ◽

Tandem Mass Spectrometry ◽

Human Plasma ◽

High Performance ◽

Tandem Mass ◽

Farnesyl Transferase ◽

Farnesyl Transferase Inhibitor

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A phase I and pharmacokinetic study of the farnesyl transferase inhibitor, CP-609,754 in patients with advanced solid tumors

European Journal of Cancer ◽

10.1016/s0959-8049(02)80825-5 ◽

2002 ◽

Vol 38 ◽

pp. S56

Keyword(s):

Phase I ◽

Solid Tumors ◽

Pharmacokinetic Study ◽

Advanced Solid Tumors ◽

Farnesyl Transferase ◽

Farnesyl Transferase Inhibitor

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Phase 1 trial and pharmacokinetic study of the farnesyl transferase inhibitor tipifarnib in children and adolescents with refractory leukemias: A report from the Children's Oncology Group

Pediatric Blood & Cancer ◽

10.1002/pbc.22775 ◽

2010 ◽

Vol 56 (2) ◽

pp. 226-233 ◽

Cited By ~ 12

Author(s):

Brigitte C. Widemann ◽

Robert J. Arceci ◽

Nalini Jayaprakash ◽

Elizabeth Fox ◽

Peter Zannikos ◽

...

Keyword(s):

Children And Adolescents ◽

Pharmacokinetic Study ◽

Phase 1 ◽

Oncology Group ◽

Farnesyl Transferase ◽

Phase 1 Trial ◽

Farnesyl Transferase Inhibitor

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Mass balance study with ixabepilone using Accelerator Mass Spectrometry

Journal of Clinical Oncology ◽

10.1200/jco.2004.22.90140.2036 ◽

2004 ◽

Vol 22 (14_suppl) ◽

pp. 2036-2036

Author(s):

J. H. Beumer ◽

G. Lappin ◽

M. Cohen ◽

S. Galbraith ◽

R. C. Garner ◽

...

Keyword(s):

Mass Spectrometry ◽

Mass Balance ◽

Accelerator Mass Spectrometry ◽

Balance Study ◽

Mass Balance Study

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Phase I and pharmacokinetic study of the orally administered farnesyl transferase inhibitor R115777 in patients with advanced solid tumors

Anti-Cancer Drugs ◽

10.1097/00001813-200103000-00003 ◽

2001 ◽

Vol 12 (3) ◽

pp. 193-197 ◽

Cited By ~ 60

Author(s):

C JA Punt ◽

L van Maanen ◽

C JJG Bol ◽

W F Seifert ◽

D JTh Wagener

Keyword(s):

Phase I ◽

Solid Tumors ◽

Pharmacokinetic Study ◽

Advanced Solid Tumors ◽

Farnesyl Transferase ◽

Farnesyl Transferase Inhibitor

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Phase I clinical and pharmacokinetic study of the farnesyl transferase inhibitor BMS-214662 administered intravenously for five consecutive days in patients with advanced malignancies

Journal of Clinical Oncology ◽

10.1200/jco.2004.22.14_suppl.2033 ◽

2004 ◽

Vol 22 (14_suppl) ◽

pp. 2033-2033 ◽

Cited By ~ 1

Author(s):

R. S. McDermott ◽

N. J. Meropol ◽

L. M. Weiner ◽

G. Yeslow ◽

G. R. Hudes

Keyword(s):

Phase I ◽

Pharmacokinetic Study ◽

Farnesyl Transferase ◽

Advanced Malignancies ◽

Farnesyl Transferase Inhibitor

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Mass balance study of TAS-102 using 14C labeling analyzed by accelerator mass spectrometry.

Journal of Clinical Oncology ◽

10.1200/jco.2015.33.15_suppl.2563 ◽

2015 ◽

Vol 33 (15_suppl) ◽

pp. 2563-2563

Author(s):

James J. Lee ◽

Jabed Seraj ◽

Kenichiro Yoshida ◽

Milind Narurkar ◽

Hirokazu Mizuguchi ◽

...

Keyword(s):

Mass Spectrometry ◽

Mass Balance ◽

Accelerator Mass Spectrometry ◽

Balance Study ◽

Mass Balance Study ◽

14C Labeling

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Human mass balance study of TAS-102 using 14C analyzed by accelerator mass spectrometry

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-016-2965-2 ◽

2016 ◽

Vol 77 (3) ◽

pp. 515-526 ◽

Cited By ~ 10

Author(s):

James J. Lee ◽

Jabed Seraj ◽

Kenichiro Yoshida ◽

Hirokazu Mizuguchi ◽

Sandra Strychor ◽

...

Keyword(s):

Mass Spectrometry ◽

Mass Balance ◽

Accelerator Mass Spectrometry ◽

Balance Study ◽

Mass Balance Study

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A Single Dose Mass Balance Study of the Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Humans Using Accelerator Mass Spectrometry

Drug Metabolism and Disposition ◽

10.1124/dmd.111.039339 ◽

2011 ◽

Vol 39 (8) ◽

pp. 1460-1467 ◽

Cited By ~ 40

Author(s):

Richard A. Graham ◽

Bert L. Lum ◽

Glenn Morrison ◽

Ilsung Chang ◽

Karin Jorga ◽

...

Keyword(s):

Mass Spectrometry ◽

Single Dose ◽

Mass Balance ◽

Accelerator Mass Spectrometry ◽

Hedgehog Pathway ◽

Balance Study ◽

Mass Balance Study ◽

Hedgehog Pathway Inhibitor

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