Phase 1 trial and pharmacokinetic study of the farnesyl transferase inhibitor tipifarnib in children and adolescents with refractory leukemias: A report from the Children's Oncology Group

Brigitte C. Widemann; Robert J. Arceci; Nalini Jayaprakash; Elizabeth Fox; Peter Zannikos; Wendy Goodspeed; Anne Goodwin; John J. Wright; Susan M. Blaney; Peter C. Adamson; Frank M. Balis

doi:10.1002/pbc.22775

Phase 1 trial and pharmacokinetic study of the farnesyl transferase inhibitor tipifarnib in children and adolescents with refractory leukemias: A report from the Children's Oncology Group

Pediatric Blood & Cancer ◽

10.1002/pbc.22775 ◽

2010 ◽

Vol 56 (2) ◽

pp. 226-233 ◽

Cited By ~ 12

Author(s):

Brigitte C. Widemann ◽

Robert J. Arceci ◽

Nalini Jayaprakash ◽

Elizabeth Fox ◽

Peter Zannikos ◽

...

Keyword(s):

Children And Adolescents ◽

Pharmacokinetic Study ◽

Phase 1 ◽

Oncology Group ◽

Farnesyl Transferase ◽

Phase 1 Trial ◽

Farnesyl Transferase Inhibitor

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Abstract P162: Phase 1 trial of selinexor in children and adolescents with recurrent/refractory solid and CNS tumors (ADVL1414): A Children’s Oncology Group Phase 1 Consortium trial

10.1158/1535-7163.targ-21-p162 ◽

2021 ◽

Author(s):

Adam L. Green ◽

Charles G. Minard ◽

Xiaowei Liu ◽

Joel M. Reid ◽

Kerice Pinkney ◽

...

Keyword(s):

Children And Adolescents ◽

Phase 1 ◽

Cns Tumors ◽

Oncology Group ◽

Phase 1 Trial

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Faculty Opinions recommendation of A phase 1 study of cabozantinib in children and adolescents with recurrent or refractory solid tumors, including CNS tumors: Trial ADVL1211, a report from the Children's Oncology Group.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.733109543.793558288 ◽

2019 ◽

Author(s):

Stephen Lessnick

Keyword(s):

Children And Adolescents ◽

Solid Tumors ◽

Phase 1 ◽

Cns Tumors ◽

Oncology Group ◽

Phase 1 Study

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A phase 1 trial of temsirolimus and intensive re-induction chemotherapy for 2nd or greater relapse of acute lymphoblastic leukaemia: a Children's Oncology Group study (ADVL1114)

British Journal of Haematology ◽

10.1111/bjh.14569 ◽

2017 ◽

Vol 177 (3) ◽

pp. 467-474 ◽

Cited By ~ 14

Author(s):

Susan R. Rheingold ◽

Sarah K. Tasian ◽

James A. Whitlock ◽

David T. Teachey ◽

Michael J. Borowitz ◽

...

Keyword(s):

Acute Lymphoblastic Leukaemia ◽

Induction Chemotherapy ◽

Lymphoblastic Leukaemia ◽

Phase 1 ◽

Oncology Group ◽

Oncology Group Study ◽

Phase 1 Trial

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Phase 1 trial of temsirolimus in combination with irinotecan and temozolomide in children, adolescents and young adults with relapsed or refractory solid tumors: A children's oncology group study

Pediatric Blood & Cancer ◽

10.1002/pbc.24874 ◽

2013 ◽

Vol 61 (5) ◽

pp. 833-839 ◽

Cited By ~ 55

Author(s):

Rochelle Bagatell ◽

Robin Norris ◽

Ashish M. Ingle ◽

Charlotte Ahern ◽

Stephan Voss ◽

...

Keyword(s):

Young Adults ◽

Solid Tumors ◽

Phase 1 ◽

Adolescents And Young Adults ◽

Oncology Group ◽

Oncology Group Study ◽

Phase 1 Trial

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A phase II study of the farnesyl transferase inhibitor, tipifarnib, in children with recurrent or progressive high-grade glioma, medulloblastoma/primitive neuroectodermal tumor, or brainstem glioma: A children's oncology group study

Cancer ◽

10.1002/cncr.23078 ◽

2007 ◽

Vol 110 (11) ◽

pp. 2535-2541 ◽

Cited By ~ 57

Author(s):

Maryam Fouladi ◽

H. Stacy Nicholson ◽

Tianni Zhou ◽

Fred Laningham ◽

Kathleen J. Helton ◽

...

Keyword(s):

Phase Ii ◽

Primitive Neuroectodermal Tumor ◽

Phase Ii Study ◽

High Grade Glioma ◽

Brainstem Glioma ◽

High Grade ◽

Oncology Group ◽

Oncology Group Study ◽

Farnesyl Transferase ◽

Farnesyl Transferase Inhibitor

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A phase I and pharmacokinetic study of the farnesyl transferase inhibitor, CP-609,754 in patients with advanced solid tumors

European Journal of Cancer ◽

10.1016/s0959-8049(02)80825-5 ◽

2002 ◽

Vol 38 ◽

pp. S56

Keyword(s):

Phase I ◽

Solid Tumors ◽

Pharmacokinetic Study ◽

Advanced Solid Tumors ◽

Farnesyl Transferase ◽

Farnesyl Transferase Inhibitor

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Evaluation of Accelerator Mass Spectrometry in a Human Mass Balance and Pharmacokinetic Study–Experience with14C-labeled (R)-6-[Amino(4- chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1- methyl-2(1H)-quinolinone (R115777), a Farnesyl Transferase Inhibitor

Drug Metabolism and Disposition ◽

10.1124/dmd.30.7.823 ◽

2002 ◽

Vol 30 (7) ◽

pp. 823-830 ◽

Cited By ~ 61

Author(s):

R. C. Garner ◽

I. Goris ◽

A. A. E. Laenen ◽

E. Vanhoutte ◽

W. Meuldermans ◽

...

Keyword(s):

Mass Spectrometry ◽

Mass Balance ◽

Pharmacokinetic Study ◽

Accelerator Mass Spectrometry ◽

Farnesyl Transferase ◽

Farnesyl Transferase Inhibitor ◽

Study Experience

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PDCT-04. PHASE 1 TRIAL OF WEE1 KINASE INHIBITOR AZD1775 COMBINED WITH RADIATION THERAPY FOR CHILDREN WITH NEWLY DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMA: A REPORT FROM THE CHILDREN’S ONCOLOGY GROUP PHASE 1 PILOT CONSORTIUM (ADVL1217)

Neuro-Oncology ◽

10.1093/neuonc/noy148.834 ◽

2018 ◽

Vol 20 (suppl_6) ◽

pp. vi201-vi201

Author(s):

Sabine Mueller ◽

Xiaodong Yang ◽

Sharmistha Pal ◽

Ralph Ermioian ◽

Elizabeth Fox ◽

...

Keyword(s):

Radiation Therapy ◽

Kinase Inhibitor ◽

Phase 1 ◽

Diffuse Intrinsic Pontine Glioma ◽

Newly Diagnosed ◽

Oncology Group ◽

Pontine Glioma ◽

Phase 1 Trial ◽

Wee1 Kinase

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Phase 1 trial of brentuximab vedotin in combination with gemcitabine for pediatric and young adult patients with relapsed or refractory Hodgkin lymphoma, a Children’s Oncology Group report.

Journal of Clinical Oncology ◽

10.1200/jco.2015.33.15_suppl.8544 ◽

2015 ◽

Vol 33 (15_suppl) ◽

pp. 8544-8544 ◽

Cited By ~ 1

Author(s):

Peter D. Cole ◽

Monika Metzger ◽

Richard A. Drachtman ◽

Terzah M. Horton ◽

Xiaowei Liu ◽

...

Keyword(s):

Young Adult ◽

Hodgkin Lymphoma ◽

Phase 1 ◽

Brentuximab Vedotin ◽

Adult Patients ◽

Oncology Group ◽

Phase 1 Trial ◽

Group Report ◽

Refractory Hodgkin Lymphoma

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Phase 1 trial of trametinib alone and in combination with dabrafenib in children and adolescents with relapsed solid tumors or neurofibromatosis type 1 (NF1) progressive plexiform neurofibromas (PN).

Journal of Clinical Oncology ◽

10.1200/jco.2018.36.15_suppl.10537 ◽

2018 ◽

Vol 36 (15_suppl) ◽

pp. 10537-10537 ◽

Cited By ~ 4

Author(s):

Birgit Geoerger ◽

Christopher L. Moertel ◽

James Whitlock ◽

Geoffrey Brian McCowage ◽

Mark W. Kieran ◽

...

Keyword(s):

Children And Adolescents ◽

Solid Tumors ◽

Neurofibromatosis Type 1 ◽

Phase 1 ◽

Neurofibromatosis Type ◽

Phase 1 Trial ◽

Plexiform Neurofibromas

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